Galmic

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Galmic
Galmic.svg
Identifiers
  • methyl 6-amino-2-[[(4R,11R,18R)-18-(cyclohexylmethylcarbamoyl)-11-(9H-fluoren-9-ylcarbamoyl)-4,7,11,14,18,21-hexamethyl-2,9,16-trioxo-6,13,20-trioxa-3,10,17,22,23,24-hexazatetracyclo[17.2.1.15,8.112,15]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-4-carbonyl]amino]hexanoate
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C51H60N10O11
Molar mass 989.100 g·mol−1
3D model (JSmol)
  • c7cccc3c7-c4ccccc4C3NC(=O)C(C)(c(oc6C)nc6C(=O)NC2(C)C(=O)NC(C(=O)OC)CCCCN)NC(=O)c1nc(oc1C)C(C)(NC(=O)c5nc2oc5C)C(=O)NCC8CCCCC8
  • InChI=1S/C51H60N10O11/c1-26-36-41(64)61-51(6,45(68)55-38-32-21-13-11-19-30(32)31-20-12-14-22-33(31)38)48-58-37(28(3)72-48)40(63)60-50(5,44(67)54-34(42(65)69-7)23-15-16-24-52)47-57-35(27(2)71-47)39(62)59-49(4,46(56-36)70-26)43(66)53-25-29-17-9-8-10-18-29/h11-14,19-22,29,34,38H,8-10,15-18,23-25,52H2,1-7H3,(H,53,66)(H,54,67)(H,55,68)(H,59,62)(H,60,63)(H,61,64)/t34-,49-,50-,51-/m0/s1 X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR. [1] It has anticonvulsant, antidepressant and analgesic effects in animal studies, [2] but also inhibits memory functions. [3]

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References

  1. ↑ Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). "Synthesis of galmic: a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America. 101 (48): 16727–32. Bibcode:2004PNAS..10116727C. doi: 10.1073/pnas.0407543101 . PMC   534730 . PMID   15557002.
  2. ↑ Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). "Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests". Proceedings of the National Academy of Sciences of the United States of America. 101 (28): 10470–5. Bibcode:2004PNAS..10110470B. doi: 10.1073/pnas.0403802101 . PMC   478593 . PMID   15240875.
  3. ↑ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides. 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID   15944018. S2CID   2142254.


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