Gastrokine-1

GKN1
Identifiers
Aliases	GKN1 , AMP18, BRICD1, CA11, FOV, foveolin, gastrokine 1
External IDs	OMIM: 606402; MGI: 1913533; HomoloGene: 10487; GeneCards: GKN1; OMA:GKN1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.3 Start 68,974,573 bp [1] End 68,980,980 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 87,322,632 bp [2] End 87,327,924 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa pylorus cardia mucosa of ileum body of stomach fundus decidua left adrenal gland right adrenal cortex left adrenal cortex Top expressed in epithelium of stomach mucous cell of stomach pyloric antrum duodenum interventricular septum esophagus decidua cornea jejunum islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component extracellular region extracellular space cellular component Biological process digestion positive regulation of cell division regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56287 66283 Ensembl ENSG00000169605 ENSMUSG00000030050 UniProt Q9NS71 Q9CR36 RefSeq (mRNA) NM_019617 NM_025466 RefSeq (protein) NP_062563 NP_079742 Location (UCSC) Chr 2: 68.97 – 68.98 Mb Chr 6: 87.32 – 87.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000169605 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030050 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (August 2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa" (PDF). American Journal of Physiology. Gastrointestinal and Liver Physiology. 285 (2): G332-43. doi:10.1152/ajpgi.00453.2002. PMID   12851218. S2CID   2860022. Archived from the original (PDF) on 2019-03-02.
6. Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, et al. (October 2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer". International Journal of Oncology. 19 (4): 701–7. doi:10.3892/ijo.19.4.701. PMID   11562744.
7. "Entrez Gene: GKN1 gastrokine 1".

Further reading

• Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (May 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Japanese Journal of Cancer Research. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMC   5926377 . PMID   10835488.
• Westley BR, Griffin SM, May FE (June 2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C". Biochemistry. 44 (22): 7967–75. doi:10.1021/bi047287n. PMID   15924415.
• Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG (July 2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 289 (1): G163-71. doi:10.1152/ajpgi.00013.2005. PMC   1444946 . PMID   15961882.
• Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, et al. (February 2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection". Digestive and Liver Disease. 39 (2): 122–9. doi:10.1016/j.dld.2006.09.017. PMID   17092786.