This article needs additional citations for verification . (October 2018) (Learn how and when to remove this template message) |
Geriatric onset laryngeal paralysis polyneuropathy (GOLPP), previously described as idiopathic laryngeal paralysis (ILP), is a degenerative polyneuropathy that most commonly occurs in older medium-to-large breed dogs. [1]
Animals with this condition have historically tended to come to veterinary attention when they develop difficulties related to opening and closing the arytenoid cartilages of the larynx in the throat of the animal, causing difficulty with breathing and swallowing, and was therefore for many years the condition was believed to be an idiopathic form of laryngeal paralysis, meaning "of unknown cause". Investigations into idiopathic laryngeal paralysis by two groups (in Michigan and Tennessee) between 2005 and 2013 showed that dogs with ILP did not only suffer dysfunction of the laryngeal nerves; they found that this was just one prominent symptom of what was a very gradually progressing polyneuropathy of old age, which also affected other nerves in the body. This finding, now generally believed correct following further research, has led to the disease commonly being proposed in veterinary discussion and papers, to be renamed from ILP to GOLPP, to better reflect this new understanding since this discovery.
Medium-to-large breed dogs are most commonly affected by GOLPP, [1] including the Afghan hound, golden retriever, Irish setter, Labrador retriever, Rottweiler, St Bernard and standard poodle. [2]
The German Shepherd is a breed of medium to large-sized working dog that originated in Germany. In the English language, the breed's officially recognized name is German Shepherd Dog (GSD). The breed was officially known as the Alsatian in the UK from after the First World War until 1977 when its name was changed back to German Shepherd. Despite its primitive, wolf-like appearance the German Shepherd is a relatively modern breed of dog, with their origin dating to 1899.
The Cavalier King Charles Spaniel is a small spaniel classed as a toy dog by The Kennel Club and the American Kennel Club, that originated in the United Kingdom. Since 2000, it has grown in popularity in the United States and ranks as the 19th most popular pure-breed in the United States. It has a silky, smooth coat and commonly a smooth undocked tail. The breed standard recognizes four colors: Blenheim, Tricolor (black/white/tan), Black and Tan, and Ruby. The breed is generally friendly, affectionate and good with both children and other animals; however, they require a lot of human interaction. Since they are family dogs, it is recommended to not leave one alone for long periods at a time. The expected average lifespan of a Cavalier King Charles Spaniel is between nine and fourteen years.
The Nova Scotia Duck Tolling Retriever is a medium-sized gundog bred primarily for hunting. It is often referred to as a "toller". It is the smallest of the retrievers, and is often mistaken for a small Golden Retriever. Tollers are known to be intelligent, easy to please, alert, and high-energy dogs. The name "toller" is derived from their ability to lure waterfowl within gunshot range. The breed originated in Yarmouth County, Nova Scotia, Canada. The American Kennel Club ranks the toller as the 87th most popular dog breed.
The recurrent laryngeal nerve (RLN) is a branch of the vagus nerve that supplies all the intrinsic muscles of the larynx, with the exception of the cricothyroid muscles. There are two recurrent laryngeal nerves, right and left. The right and left nerves are not symmetrical, with the left nerve looping under the aortic arch, and the right nerve looping under the right subclavian artery then traveling upwards. They both travel alongside of the trachea. Additionally, the nerves are one of few nerves that follow a recurrent course, moving in the opposite direction to the nerve they branch from, a fact from which they gain their name.
The Leonberger is a giant dog breed, whose name derives from the city of Leonberg in Baden-Württemberg, Germany. According to legend, the Leonberger was ostensibly bred as a "symbolic dog" that would mimic the lion in the town coat of arms. It is in the Working Group for dog shows such as Crufts, but not at the World Dog Show.
Laryngeal paralysis in animals is a condition in which the nerves and muscles that control the movements of one or both arytenoid cartilages of the larynx cease to function, and instead of opening during aspiration and closing during swallowing, the arytenoids remain stationary in a somewhat neutral position. Specifically, the muscle that causes abduction of the arytenoid cartilage, the cricoarytenoideus dorsalis muscle, ceases to function. This leads to inadequate ventilation during exercise and during thermoregulatory panting as well as incomplete protection of the airway during swallowing.
The health of dogs is a well studied area in veterinary medicine.
Panosteitis, sometimes shortened to pano among breeders, is an occasionally seen long bone condition in large breed dogs. It manifests with sudden, unexplained pain and lameness that may shift from leg to leg, usually between 5 and 14 months of age, earning the nickname "growing pains. " Signs such as fever, weight loss, anorexia, and lethargy can also be seen. The cause is unknown, but genetics, stress, infection, metabolism, or an autoimmune component may be factors. It has also been suggested that rapid growth and high-protein food are involved in the pathogenesis. Whole blood analysis may show an elevated white blood cell count; this finding lends support to the theory that panosteitis is due to an infection.
Craniomandibular osteopathy, also known as lion's jaw, is a developmental disease in dogs causing extensive bony changes in the mandible and skull. In this disease, a cyclical resorption of normal bone and replacement by immature bone occurs along the inner and outer surfaces of the affected bones. It usually occurs between the ages of 3 and 8 months. Breeds most commonly affected include the West Highland White Terrier, Scottish Terrier, Cairn Terrier, and Boston Terrier. It is rare in large-breed dogs, but it has been reported. Symptoms include firm swelling of the jaw, drooling, pain, and difficulty eating.
Polyneuropathy in dogs and cats is a collection of peripheral nerve disorders that often are breed-related in these animals. Polyneuropathy indicates that multiple nerves are involved, unlike mononeuropathy. Polyneuropathy usually involves motor nerve dysfunction, also known as lower motor neuron disease. Symptoms include decreased or absent reflexes and muscle tone, weakness, or paralysis. It often occurs in the rear legs and is bilateral. Most are chronic problems with a slow onset of symptoms, but some occur suddenly.
Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of meningoencephalitis. GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. The cause is only known to be noninfectious and is considered at this time to be idiopathic. Because lesions resemble those seen in allergic meningoencephalitis, GME is thought to have an immune-mediated cause, but it is also thought that the disease may be based on an abnormal response to an infectious agent. One study searched for viral DNA from canine herpesvirus, canine adenovirus, and canine parvovirus in brain tissue from dogs with GME, necrotizing meningoencephalitis, and necrotizing leukoencephalitis, but failed to find any.
Follicular dysplasia is a genetic disease of dogs causing alopecia, or hair loss. It is caused by hair follicles that are misfunctioning due to structural abnormality. There are several types, some affecting only certain breeds. Diagnosis is achieved through a biopsy, and treatment is rarely successful. Certain breeds, such as the Mexican Hairless Dog and Chinese Crested Dog, are bred specifically for alopecia.
Progressive retinal atrophy (PRA) is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, it is characterized by the bilateral degeneration of the retina, causing progressive vision loss culminating in blindness. The condition in nearly all breeds is inherited as an autosomal recessive trait, with the exception of the Siberian Husky and the Bullmastiff. There is no treatment.
Cerebellar abiotrophy, also called cerebellar cortical abiotrophy, or cerebellar degeneration, is a genetic neurological disease in animals best known to affect certain breeds of horses, dogs and cats. It can also develop in humans. It develops when the neurons known as Purkinje cells, located in the cerebellum of the brain, begin to die off. These cells affect balance and coordination. They have a critical role to play in the brain. The Purkinje layer allows communication between the granular and molecular cortical layers in the cerebellum. Put simply, without Purkinje cells, an animal loses its sense of space and distance, making balance and coordination difficult. People with damage to the cerebellum can experience symptoms like unsteady gait, poor muscle control, and trouble speaking or swallowing.
Vocal fold paresis, also known as recurrent laryngeal nerve paralysis or vocal fold paralysis, is an injury to one or both recurrent laryngeal nerves (RLNs), which control all muscles of the larynx except for the cricothyroid muscle. The RLN is important for speaking, breathing and swallowing.
Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS). Onset is typically after the age of 7 years and it is seen most frequently in the German shepherd dog, Pembroke Welsh corgi, and boxer dog, though the disorder is strongly associated with a gene mutation in SOD1 that has been found in 43 breeds as of 2008, including the wire fox terrier, Chesapeake Bay retriever, Rhodesian ridgeback, and Cardigan Welsh corgi. Progressive weakness and incoordination of the rear limbs are often the first signs seen in affected dogs, with progression over time to complete paralysis. Myelin is an insulating sheath around neurons in the spinal cord. One proposed cause of degenerative myelopathy is that the immune system attacks this sheath, breaking it down. This results in a loss of communication between nerves in lower body of the animal and the brain.
Sebaceous adenitis in an uncommon skin disease found in some breeds of dog, and more rarely in cats, rabbits and horses. characterised by an inflammatory response against the dog's sebaceous glands, which can lead to the destruction of the gland. It was first described in veterinary literature in the 1980s.
Brachycephalic syndrome is a pathological condition affecting short nosed dogs and cats which can lead to severe respiratory distress. There are four different anatomical abnormalities that contribute to the disease, all of which occur more commonly in brachycephalic breeds: an elongated soft palate, stenotic nares, a hypoplastic trachea, and everted laryngeal saccules. Because all of these components make it more difficult to breathe, in situations of exercise, stress, or heat, an animal with these abnormalities may be unable to take deep or fast enough breaths to blow off carbon dioxide. This leads to distress and further increases respiratory rate and heart rate, creating a vicious cycle that can quickly lead to a life-threatening situation.
Idiopathic head tremors (IHT) in dogs are characterized by involuntary lateral or vertical movement of the head. Idiopathic head tremors are ordinarily considered a benign disease characterized by uncontrollable head tremors of spontaneous initiation and cessation. These head tremors are considered idiopathic because the cause is not apparent, but nervous system disorders, seizures and head injuries may be significant contributors of idiopathic head tremors in dogs. Head tremors are usually not associated with any other symptoms, although some dogs have other signs of disease in addition to head tremors.