Degenerative disease

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Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. [1]

Contents

In neurodegenerative diseases, cells of the central nervous system stop working or die via neurodegeneration. An example of this is Alzheimer's disease. [2] The other two common groups of degenerative diseases are those that affect circulatory system (e.g. coronary artery disease) and neoplastic diseases (e.g. cancers). [1]

Many degenerative diseases exist and some are related to aging. Normal bodily wear or lifestyle choices (such as exercise or eating habits) may worsen degenerative diseases, depending on the specific condition. [1] Sometimes the main or partial cause behind such diseases is genetic. [3] Thus some are clearly hereditary like Huntington's disease. [4] Other causes include viruses, poisons or chemical exposures, while sometimes, the underlying cause remains unknown. [3]

Some degenerative diseases can be cured. In those that can not, it may be possible to alleviate the symptoms. [1]

Examples

See also

References

  1. 1 2 3 4 5 "What is Degenerative Disease". docdoc.com.sg. Archived from the original on 2018-09-17. Retrieved 2018-09-17.
  2. ↑ "neurodegenerative disorder". National Cancer Institute. 2011-02-02. Archived from the original on 2018-04-23. Retrieved 2018-09-17.
  3. 1 2 "Neurodegenerative Diseases". Archived from the original on 2018-07-28. Retrieved 2018-09-17.
  4. 1 2 Nopoulos, PC (2016). "Huntington disease: a single-gene degenerative disorder of the striatum". Dialogues in Clinical Neuroscience. 18 (1): 91–98. doi:10.31887/DCNS.2016.18.1/pnopoulos. ISSN   1294-8322. PMC   4826775 . PMID   27069383.
  5. 1 2 3 4 Soto, C; Satani, N (2011). "The intricate mechanisms of neurodegeneration in prion diseases". Trends in Molecular Medicine. 17 (1): 14–24. doi:10.1016/j.molmed.2010.09.001. ISSN   1471-4914. PMC   3056171 . PMID   20889378.
  6. ↑ Patzkó, Á; Shy, ME (2011). "Update on Charcot-Marie-Tooth Disease". Current Neurology and Neuroscience Reports. 11 (1): 78–88. doi:10.1007/s11910-010-0158-7. ISSN   1528-4042. PMC   3685483 . PMID   21080241.
  7. ↑ Maroon, JC; Winkelman, R; Bost, J; Amos, A; Mathyssek, C; Miele, V (2015-02-11). "Chronic Traumatic Encephalopathy in Contact Sports: A Systematic Review of All Reported Pathological Cases". PLOS ONE. 10 (2): e0117338. Bibcode:2015PLoSO..1017338M. doi: 10.1371/journal.pone.0117338 . ISSN   1932-6203. PMC   4324991 . PMID   25671598. (Erratum:  doi: 10.1371/journal.pone.0130507 , PMID   26039052,  Retraction Watch . If the erratum has been checked and does not affect the cited material, please replace {{ erratum |...}} with {{ erratum |...|checked=yes}}.)
  8. ↑ Fraser-Pitt, D; O'Neil, D (2015). "Cystic fibrosis – a multiorgan protein misfolding disease". Future Science OA. 1 (2): FSO57. doi:10.4155/fso.15.57. ISSN   2056-5623. PMC   5137970 . PMID   28031875.
  9. ↑ "Cytochrome c oxidase deficiency". rarediseases.info.nih.gov. Archived from the original on 2017-10-22. Retrieved 2018-09-17.
  10. ↑ "Ehlers-Danlos syndromes". rarediseases.info.nih.gov. Archived from the original on 2018-06-16. Retrieved 2018-09-17.
  11. ↑ Delatycki, M; Williamson, R; Forrest, S (2000). "Friedreich ataxia: an overview". Journal of Medical Genetics. 37 (1): 1–8. doi:10.1136/jmg.37.1.1. ISSN   0022-2593. PMC   1734457 . PMID   10633128.
  12. ↑ Warren, JD; Rohrer, JD; Rossor, MN (2013-08-06). "Frontotemporal dementia". The BMJ. 347: f4827. doi:10.1136/bmj.f4827. ISSN   0959-8138. PMC   3735339 . PMID   23920254.
  13. ↑ Barik, R (2016). "Degenerative aortic valve disease and coronary artery disease are either side of a coin". Indian Heart Journal. 68 (3): 432. doi:10.1016/j.ihj.2015.09.010. ISSN   0019-4832. PMC   4911461 . PMID   27316510.
  14. ↑ Li, H; Zou, Y; Bao, X; Wang, H; Wang, J; Jin, H; Che, Y; Tang, X (2016). "Monozygotic twins with infantile neuroaxonal dystrophy: A case report and literature review". Experimental and Therapeutic Medicine. 12 (5): 3387–3389. doi:10.3892/etm.2016.3761. ISSN   1792-0981. PMC   5103811 . PMID   27882168.
  15. ↑ Davidson, AE; Hayes, S; Hardcastle, AJ; Tuft, SJ (2014). "The pathogenesis of keratoconus". Eye. 28 (2): 189–195. doi:10.1038/eye.2013.278. ISSN   0950-222X. PMC   3930280 . PMID   24357835.
  16. ↑ Wallang, BS; Das, S (2013). "Keratoglobus". Eye. 27 (9): 1004–1012. doi:10.1038/eye.2013.130. ISSN   0950-222X. PMC   3772364 . PMID   23807384.
  17. ↑ van der Knaap, MS; Bugiani, M (2017). "Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms". Acta Neuropathologica. 134 (3): 351–382. doi:10.1007/s00401-017-1739-1. ISSN   0001-6322. PMC   5563342 . PMID   28638987.
  18. ↑ Anand, A; Sharma, K; Chen, W; Sharma, NK (2014). "Using Current Data to Define New Approach in Age Related Macular Degeneration: Need to Accelerate Translational Research". Current Genomics. 15 (4): 266–277. doi:10.2174/1389202915666140516204512. ISSN   1389-2029. PMC   4133950 . PMID   25132797.
  19. ↑ Gao, L; Luo, F; Hui, R; Zhou, X (2010). "Recent molecular biological progress in Marfan syndrome and Marfan-associated disorders". Ageing Research Reviews. 9 (3): 363–368. doi:10.1016/j.arr.2009.09.001. ISSN   1568-1637. PMID   19772952. S2CID   205666350.
  20. ↑ "MELAS Syndrome". NORD (National Organization for Rare Disorders). Archived from the original on 2017-02-20. Retrieved 2018-09-17.
  21. ↑ El-Hattab, AW; Scaglia, F (2013). "Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options". Neurotherapeutics. 10 (2): 186–198. doi:10.1007/s13311-013-0177-6. ISSN   1933-7213. PMC   3625391 . PMID   23385875.
  22. ↑ Hermena, Shady; Francis, Monica (2021-10-11). "Clinical Presentation, Imaging Features, and Management of Müller–Weiss Disease". Cureus. 13 (10): e18659. doi: 10.7759/cureus.18659 . ISSN   2168-8184. PMC   8579404 . PMID   34786245.
  23. ↑ Fitzner, D; Simons, M (2010). "Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies". Current Neuropharmacology. 8 (3): 305–315. doi:10.2174/157015910792246218. ISSN   1570-159X. PMC   3001222 . PMID   21358979.
  24. ↑ Ubhi, K; Low, P; Masliah, E (2011). "Multiple System Atrophy: A Clinical and Neuropathological Perspective". Trends in Neurosciences. 34 (11): 581–590. doi:10.1016/j.tins.2011.08.003. ISSN   0166-2236. PMC   3200496 . PMID   21962754.
  25. ↑ Shin, J; Tajrishi, MM; Ogura, Y; Kumar, A (2013). "Wasting Mechanisms in Muscular Dystrophy". The International Journal of Biochemistry & Cell Biology. 45 (10): 2266–2279. doi:10.1016/j.biocel.2013.05.001. ISSN   1357-2725. PMC   3759654 . PMID   23669245.
  26. ↑ Mole, SE; Williams, Ruth E. (1993). "Neuronal Ceroid-Lipofuscinoses – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY". In Adam, Margaret P.; Ardinger, Holly H.; Pagon, Roberta A.; Wallace, Stephanie E. (eds.). Neuronal Ceroid-Lipofuscinoses. University of Washington, Seattle. PMID   20301601 . Retrieved 2018-09-17.{{cite book}}: |work= ignored (help)
  27. ↑ Evans, WRH; Hendriksz, CJ (2017). "Niemann–Pick type C disease – the tip of the iceberg? A review of neuropsychiatric presentation, diagnosis and treatment". BJPsych Bulletin. 41 (2): 109–114. doi:10.1192/pb.bp.116.054072. ISSN   2056-4694. PMC   5376728 . PMID   28400970.
  28. 1 2 Shen, Y; Zhang, Y; Shen, L (2013-04-15). "Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla". BMC Musculoskeletal Disorders. 14: 136. doi: 10.1186/1471-2474-14-136 . ISSN   1471-2474. PMC   3659090 . PMID   23587336.
  29. ↑ Bazan, IS; Fares, WH (2015-08-17). "Pulmonary hypertension: diagnostic and therapeutic challenges". Therapeutics and Clinical Risk Management. 11: 1221–1233. doi: 10.2147/TCRM.S74881 . ISSN   1176-6336. PMC   4544628 . PMID   26316767.
  30. ↑ Owolabi, LF (2013). "Progressive Supranuclear Palsy Misdiagnosed as Parkinson's Disease: A Case Report and Review of Literature". Annals of Medical and Health Sciences Research. 3 (Suppl1): S44 –S47. doi: 10.4103/2141-9248.121221 . ISSN   2141-9248. PMC   3853608 . PMID   24349849.
  31. ↑ Hamel, C (2006-10-11). "Retinitis pigmentosa". Orphanet Journal of Rare Diseases. 1: 40. doi: 10.1186/1750-1172-1-40 . ISSN   1750-1172. PMC   1621055 . PMID   17032466.
  32. ↑ Abdel-Ahad, P; El Chammai, M; Fneich, A; Issa, R; Kabbara, W; Richa, S (2016). "Les manifestations psychiatriques dans la polyarthrite rhumatoïde". L'Encéphale. 42 (2): 172–176. doi:10.1016/j.encep.2015.12.008. ISSN   0013-7006. PMID   26850214.
  33. 1 2 Walia, JP; Altaleb, N; Bello, A; Kruck, C; LaFave, MC; Varshney, GK; Burgess, SM; Chowdhury, B; Hurlbut, D (2015). "Long-Term Correction of Sandhoff Disease Following Intravenous Delivery of rAAV9 to Mouse Neonates". Molecular Therapy. 23 (3): 414–422. doi:10.1038/mt.2014.240. ISSN   1525-0016. PMC   4351464 . PMID   25515709.
  34. ↑ Simone, C; Ramirez, A; Bucchia, M; Rinchetti, P; Rideout, H; Papadimitriou, D; Re, DB; Corti, S (2016). "Is Spinal Muscular Atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?". Cellular and Molecular Life Sciences. 73 (5): 1003–1020. doi:10.1007/s00018-015-2106-9. ISSN   1420-682X. PMC   4756905 . PMID   26681261.
  35. ↑ Jafri, SK; Kumar, R; Ibrahim, SH (2018-06-26). "Subacute sclerosing panencephalitis – current perspectives". Pediatric Health, Medicine and Therapeutics. 9: 67–71. doi: 10.2147/PHMT.S126293 . ISSN   1179-9927. PMC   6027681 . PMID   29985487.
  36. ↑ "Brain Disease Model of Drug & Alcohol Addiction | Hazelden Betty Ford". Archived from the original on 2017-10-27.
  37. ↑ Korczyn, AD; Vakhapova, V; Grinberg, LT (2012-11-15). "Vascular dementia". Journal of the Neurological Sciences. 322 (1–2): 2–10. doi:10.1016/j.jns.2012.03.027. ISSN   0022-510X. PMC   3435447 . PMID   22575403.
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