Anti-aging movement

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The anti-aging movement is a social movement devoted to eliminating or reversing aging, or reducing the effects of it. [1] [2] A substantial portion of the attention of the movement is on the possibilities for life extension, but there is also interest in techniques such as cosmetic surgery which ameliorate the effects of aging rather than delay or defeat it. [3]

Contents

There are many scientists of this movement with different approaches. Two of the most popular proponents of the anti-aging movement include Ray Kurzweil, who says humanity can defeat aging through the advance of technology, allowing us to reach the longevity escape velocity, [4] and Aubrey de Grey, who says that the human body is a very complicated machine and, thus, can be repaired indefinitely. [5] Other scientists and significant contributors to the movement include molecular biologists, geneticists, and biomedical gerontologists such as Gary Ruvkun, Cynthia Kenyon, and Arthur D. Levinson. However, figures in the gerontology community in 2003 tried to distance their research from the perceived pseudoscience of the movement. [6]

Anti-aging medicine

Anti-aging medicine has become a budding and rapidly growing medical specialty as physicians who initially sought treatment for themselves have received training and certification in its practice [1] by organizations such as the American Academy of Anti-Aging Medicine (A4M) co-founded by Dr Robert M. Goldman and Ronald Klatz.

Human growth hormone

Central to anti-aging medicine is administration of human growth hormone. [7] Clinical studies have shown that low-dose growth hormone (GH) treatment for adults with GH deficiency changes the body composition by increasing muscle mass, decreasing fat mass, and increasing bone density and muscle strength. It also improves cardiovascular parameters (i.e. decrease of LDL cholesterol) and affects the quality of life without significant side effects. [8] [9] [10] However, it is also said to have potentially dangerous side effects when used in injectable form, if proper protocols are not followed. It is not approved for use in healthy aging patients, though the restriction is occasionally sidestepped by means of a diagnosis of some injury, organic condition, or adult growth hormone deficiency [11] which supposedly has resulted in reduced secretion of the hormone. [12]

Menopausal hormone drugs

Administration of estrogen and other hormones such as progestin were popularized by the 1966 book Feminine Forever by Robert A. Wilson. [13] However, the increase of the use of estrogen was shown to be associated with an increased risk of cancer. [14] Later, in 2002, research into the long-term effects of estrogen on post-menopausal women, the Women's Health Initiative, produced evidence that there were serious side effects. [15] Physicians who prescribe the hormones now prescribe low doses of the drugs. Research into the long-term effects of hormone replacement therapy is continuing, with a 2017 Cochrane systematic review concluding that long-term use may decrease the risk of bone fractures or postmenopausal osteoporosis, but increase the risk of stroke, heart attacks, endometrial cancer, and breast cancer. [16] Hormone therapy is generally only recommended for postmenopausal women who are at a high risk of osteoporosis when non-hormonal treatments are not suitable. [16] Hormone therapy is not suitable or advised for treating cardiovascular disease, dementia, or for preventing cognitive decline in postmenopausal women. [16] The risks of long-term hormonal therapy for women under 50 years of age have not been determined. [16]

Senolytics

This section is an excerpt from Senolytic.[ edit ]

A senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. [17] A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. [18] [19] Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging. [20]

A related concept is "senostatic", which means to suppress senescence. [21]

Scientific approaches

Biogerontology is a scientific discipline which has the same area of interest but, as a branch of gerontology, takes a more conservative approach. [22] Caloric restriction is a phenomenon introduced in anti-aging techniques which focuses on depletion of calories and taking the right amount of nutrients necessary for growth. [23]

Calorie restriction

Calorie restriction (CR) refers to a dietary restriction that focuses on less calorie intake to increase longevity and reduce age-related disease in humans. Calorie restriction maintains a low calorie intake that helps to regulate the rate of aging and increases the youthfulness of an individual or animal. [24] Low calorie intake has directly been correlated to negative energy balance which promotes low body mass index (BMI) and comparatively high plasma dehydroepiandrosterone (DHEA) for improved life expectancy. [25] Calorie restriction has widely been practiced by pregnant women and people with pre-existing medical conditions such as diabetes. The right amount of calorie restriction help pregnant women to achieve positive weight gain whereas a significant drop in calorie intake can lead to hypothalamic alterations leading to long-term effects in the offspring. [26] Moderate CR in diabetic patients increases insulin sensitivity and reduces the amount of hepatic fat in obese individual and type 2 diabetes. [27] Long term CR in older animals results in stem cell function similar to that of the younger groups. The active stem cell function helps in enhanced recovery of the damaged skeletal muscle tissue, which is slower in older individuals compared to younger individuals. [28] CR in the United States has shown a prolonged life span in women compared to men as women tend to consume 25% fewer calories than men in their lifetime. [29] The statistical analysis of CR available for anti-aging movement in humans is not sufficient enough to prove the prolonged lifespan associated with CR.

Mass movement

A substantial fraction of older people, taking their cue from alternative medicine, purchase and use herbal supplements and other products which promise relief from the incidents and dangers of aging. However, many such products are unregulated, and can instead pose serious health risks. [30]

Certain billionaires have taken interest in the concept and invest funds in research for it.

Reception

There are at least two opposite views on the prospects of anti-aging research and development. One group states that there is a great deal of over-heated rhetoric in use with respect to life extension with over-optimistic projections by its advocates. They also claim that there is little evidence that any significant breakthrough has been made, or is on the horizon. [31] Some state that this is largely due to a current lack of funding or interest in the issue. [32] A study of the commonly-used supplements and hormone treatments published in 2006 in the Cleveland Clinic Journal of Medicine showed that none of them are effective for extending life. [33] Another group notices that recent scientific successes in rejuvenation and extending the lifespan of model animals [34] [ failed verification ] and discovery of a variety of species (including humans of advanced ages) having negligible senescence give hope to achieve negligible senescence (cancel aging) for younger humans, reverse ageing, or at least significantly delay it.

Though some scientists think curing aging is impossible, there are some criticisms of both the time frame life extensionists envision (the first, perhaps somewhat crude, treatments within the next several decades, or at least before the beginning of the 22nd century) and of whether curing aging is even desirable. Common criticisms of the idea of life extension are fears it will cause the world to be more overpopulated; however, de Grey counters that by saying that since menopause would also be delayed, women could wait longer to have children and, thus, the rate of growth would actually decline as a result. Also, the slowly growing population would buy centuries of time to figure out new places to live, such as space colonies. [35]

See also

Related Research Articles

Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. Several researchers in the area, along with "life extensionists", "immortalists", or "longevists", postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement will eventually enable humans to have indefinite lifespans through complete rejuvenation to a healthy youthful condition (agerasia). The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.

Maximum life span is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity.

<span class="mw-page-title-main">Triiodothyronine</span> Chemical compound

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

Calorie restriction mimetics (CRM), also known as energy restriction mimetics, are a hypothetical class of dietary supplements or drug candidates that would, in principle, mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals and humans. CR is defined as a reduction in calorie intake of 20% to 50% without incurring malnutrition or a reduction in essential nutrients. An effective CRM would alter the key metabolic pathways involved in the effects of CR itself, leading to preserved youthful health and longer lifespan without the need to reduce food intake. The term was coined by Lane, Ingram, Roth of the National Institute on Aging in a seminal 1998 paper in the Journal of Anti-Aging Medicine, the forerunner of Rejuvenation Research. A number of genes and pathways have been shown to be involved with the actions of CR in model organisms and these represent attractive targets for drug discovery and for developing CRM. However, no effective CRM have been identified to date.

Calorie restriction is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition. The possible effect of calorie restriction on body weight management, longevity, and aging-associated diseases has been an active area of research.

Rejuvenation is a medical discipline focused on the practical reversal of the aging process.

<span class="mw-page-title-main">Tibolone</span> Chemical compound

Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated or used in combination with other medications. It is taken by mouth.

The CRON-diet is a nutrient-rich, reduced calorie diet developed by Roy Walford, Lisa Walford, and Brian M. Delaney. The CRON-diet involves calorie restriction in the hope that the practice will improve health and retard aging, while still attempting to provide the recommended daily amounts of various nutrients. Other names include CR-diet, Longevity diet, and Anti-Aging Plan. The Walfords and Delaney, among others, founded the CR Society International to promote the CRON-diet.

Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability in the lifespans of organisms. The classical theories of evolution suggest that environmental factors, such as predation, accidents, disease, and/or starvation, ensure that most organisms living in natural settings will not live until old age, and so there will be very little pressure to conserve genetic changes that increase longevity. Natural selection will instead strongly favor genes which ensure early maturation and rapid reproduction, and the selection for genetic traits which promote molecular and cellular self-maintenance will decline with age for most organisms.

Following is a list of topics related to life extension:

The following outline is provided as an overview of and topical guide to life extension:

Paola S. Timiras, born Paola Silvestri, was an endocrinologist studying stress.

<span class="mw-page-title-main">Cellular senescence</span> Phenomenon characterized by the cessation of cell division

Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. This process is known as "replicative senescence", or the Hayflick limit. Hayflick's discovery of mortal cells paved the path for the discovery and understanding of cellular aging molecular pathways. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things.

The reproductive-cell cycle theory posits that the hormones that regulate reproduction act in an antagonistic pleiotrophic manner to control aging via cell cycle signaling; promoting growth and development early in life in order to achieve reproduction, but later in life, in a futile attempt to maintain reproduction, become dysregulated and drive senescence. Rather than seeing aging as a loss of functionality as we get older, this theory defines aging as any change in an organism over time, as evidenced by the fact that if all chemical reactions in the body were stopped, no change, and thus no aging, would occur. Since the most important change in an organism through time is the chemical reactions that result in a single cell developing into a multicellular organism, whatever controls these chemical reactions that regulate cell growth, development, and death, is believed to control aging. The theory argues that these cellular changes are directed by reproductive hormones of the hypothalamic-pituitary-gonadal axis. Receptors for reproductive hormones have been found to be present in all tissues of the body. Thus, HPG axis hormones normally promote growth and development of the organism early in life in order to achieve reproduction. Hormones levels then begin to change in men around age 30 and more abruptly in women when they reach menopause, around age 50. When the HPG axis becomes unbalanced, cellular growth and development is dysregulated, and cell death and dysfunction can occur, both of which can initiate senescence, the accumulated damage to cells, tissues, and organs that occurs with the passage of time and that is associated with functional loss during aging.

<span class="mw-page-title-main">Genetics of aging</span> Overview of the genetics of aging

Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan.

A senolytic is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.

Senotherapy is an early-stage basic research field for development of possible therapeutic agents and strategies to specifically target cellular senescence, an altered cell state associated with ageing and age-related diseases. The name derives from intent of the proposed anti-aging drug to halt "senescence". As of 2019, much of the research remains preliminary and there are no drugs approved for this purpose.

The disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance. Formulated by Thomas Kirkwood, the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its various cellular processes. Therefore, a greater investment in growth and reproduction would result in reduced investment in DNA repair maintenance, leading to increased cellular damage, shortened telomeres, accumulation of mutations, compromised stem cells, and ultimately, senescence. Although many models, both animal and human, have appeared to support this theory, parts of it are still controversial. Specifically, while the evolutionary trade-off between growth and aging has been well established, the relationship between reproduction and aging is still without scientific consensus, and the cellular mechanisms largely undiscovered.

Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. SASP may also consist of exosomes and ectosomes containing enzymes, microRNA, DNA fragments, chemokines, and other bioactive factors. Soluble urokinase plasminogen activator surface receptor is part of SASP, and has been used to identify senescent cells for senolytic therapy. Initially, SASP is immunosuppressive and profibrotic, but progresses to become proinflammatory and fibrolytic. SASP is the primary cause of the detrimental effects of senescent cells.

This timeline lists notable events in the history of research into senescence or biological aging, including the research and development of life extension methods, brain aging delay methods and rejuvenation.

References

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  2. ↑ Vincent, John (2013). "The Anti-Aging Movement". In Schermer, Maartje; Pinxten, Wim (eds.). Ethics, Health Policy and (Anti-) Aging: Mixed Blessings. Springer Netherlands. p. 30. ISBN   978-94-007-3870-6. There have been a number of social movements associated with the reappraisal of age-based social categories in the last thirty years. Two such developments are the focus of this chapter. They are the Third Age movement and the Anti-aging movement. These movements present contrasting perspectives on the culturally devalued status of old age; the former seeks to celebrate old age, the latter to eliminate it.
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