Cryonics

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Technicians preparing a body for cryopreservation in 1985 Cryo surgery.jpg
Technicians preparing a body for cryopreservation in 1985

Cryonics (from Greek : κρύοςkryos, meaning "cold") is the low-temperature freezing (usually at −196 °C or −320.8 °F or 77.1 K) and storage of human remains in the hope that resurrection may be possible in the future. [1] [2] Cryonics is regarded with skepticism by the mainstream scientific community. It is generally viewed as a pseudoscience, [3] and its practice has been characterized as quackery. [4] [5]

Contents

Cryonics procedures can begin only after the "patients" are clinically and legally dead. Procedures may begin within minutes of death, [6] and use cryoprotectants to try to prevent ice formation during cryopreservation. [7] [ better source needed ] It is not possible to reanimate a corpse that has undergone vitrification, as that damages the brain, including its neural circuits. [8] [9] The first corpse to be frozen was that of James Bedford, in 1967. [10] As of 2014, about 250 bodies had been cryopreserved in the United States, and 1,500 people had made arrangements for cryopreservation of their remains. [11]

Economic considerations make it difficult for cryonics corporations to remain in business long enough to take advantage of any long-term benefits. [12] The "patients", being dead, cannot continue to pay for their own preservation. Early attempts at cryonic preservation were made in the 1960s and early 1970s; most relied on family members to pay for the preservation and ended in failure, with all but one of the companies going out of business and the corpses thawed and disposed of. [13] The remaining organization, Alcor, uses a patient care trust to ensure that their preservations can be supported indefinitely. [14]

Conceptual basis

Cryonicists argue that as long as brain structure remains intact, there is no fundamental barrier, given our current understanding of physics, to recovering its information content. Cryonics proponents go further than the mainstream consensus in saying that the brain does not have to be continuously active to survive or retain memory. Cryonicists controversially say that a human can survive even within an inactive, badly damaged brain, as long as the original encoding of memory and personality can be adequately inferred and reconstituted from what remains. [11] [15]

Cryonics uses temperatures below −130  °C, called cryopreservation, in an attempt to preserve enough brain information to permit the revival of the cryopreserved person. Cryopreservation is accomplished by freezing with or without cryoprotectant to reduce ice damage, or by vitrification to avoid ice damage. Even using the best methods, cryopreservation of whole bodies or brains is very damaging and irreversible with current technology.

Cryonicists call the human remains packed into low-temperature vats "patients". [16] They hope that some kind of presently nonexistent nanotechnology will be able to bring the dead back to life and treat the diseases that killed them. [17] Mind uploading has also been proposed. [18]

Cryonics in practice

Cryonics can be expensive. As of 2018, the cost of preparing and storing corpses using cryonics ranged from US$28,000 to $200,000. [19]

At high concentrations, cryoprotectants can stop ice formation completely. Cooling and solidification without crystal formation is called vitrification. [20] In the late 1990s, cryobiologists Gregory Fahy and Brian Wowk developed the first cryoprotectant solutions that could vitrify at very slow cooling rates while still allowing whole organ survival, for the purpose of banking transplantable organs. [21] [22] [23] This has allowed animal brains to be vitrified, thawed, and examined for ice damage using light and electron microscopy. No ice crystal damage was found; [24] cellular damage was due to dehydration and toxicity of the cryoprotectant solutions.

Costs can include payment for medical personnel to be on call for death, vitrification, transportation in dry ice to a preservation facility, and payment into a trust fund intended to cover indefinite storage in liquid nitrogen and future revival costs. [25] [26] As of 2011, U.S. cryopreservation costs can range from $28,000 to $200,000, and are often financed via life insurance. [25] KrioRus, which stores bodies communally in large dewars, charges $12,000 to $36,000 for the procedure. [27] Some customers opt to have only their brain cryopreserved ("neuropreservation"), rather than their whole body.

As of 2014, about 250 corpses have been cryogenically preserved in the U.S., and around 1,500 people have signed up to have their remains preserved. [11] As of 2016, there are four facilities that retain cryopreserved bodies, three in the U.S. and one in Russia. [2] [28]

A more recent development is Tomorrow Biostasis GmbH, a Berlin-based firm offering cryonics and standby and transportation services in Europe. Founded in 2019 by Emil Kendziorra and Fernando Azevedo Pinheiro, it partners with the European Biostasis Foundation in Switzerland for long-term corpse storage. The facility was completed in 2022. [29] [30]

It seems extremely unlikely that any cryonics company could exist long enough to take advantage of the supposed benefits offered; historically, even the most robust corporations have only a one-in-a-thousand chance of lasting 100 years. [12] Many cryonics companies have failed; as of 2018, all but one of the pre-1973 batch had gone out of business, and their stored corpses have been defrosted and disposed of. [13]

Obstacles to success

Preservation damage

Medical laboratories have long used cryopreservation to maintain animal cells, human embryos, and even some organized tissues, for periods as long as three decades. [31] But recovering large animals and organs from a frozen state is not considered possible now. [32] [21] [33] Large vitrified organs tend to develop fractures during cooling, [34] a problem worsened by the large tissue masses and very low temperatures of cryonics. [35] Without cryoprotectants, cell shrinkage and high salt concentrations during freezing usually prevent frozen cells from functioning again after thawing. Ice crystals can also disrupt connections between cells that are necessary for organs to function. [36]

Some cryonics organizations use vitrification without a chemical fixation step, [37] sacrificing some structural preservation quality for less damage at the molecular level. Some scientists, like João Pedro Magalhães, have questioned whether using a deadly chemical for fixation eliminates the possibility of biological revival, making chemical fixation unsuitable for cryonics. [38]

Outside of cryonics firms and cryonics-linked interest groups, many scientists are very skeptical about cryonics methods. Cryobiologist Dayong Gao has said, "we simply don't know if [subjects have] been damaged to the point where they've 'died' during vitrification because the subjects are now inside liquid nitrogen canisters." Based on experience with organ transplants, biochemist Ken Storey argues that "even if you only wanted to preserve the brain, it has dozens of different areas which would need to be cryopreserved using different protocols". [39]

Revival

Revival would require repairing damage from lack of oxygen, cryoprotectant toxicity, thermal stress (fracturing), and freezing in tissues that do not successfully vitrify, followed by reversing the cause of death. In many cases, extensive tissue regeneration would be necessary. [40] This revival technology remains speculative. [1]

Historically, people had little control over how their bodies were treated after death, as religion held jurisdiction over the matter. [41] But secular courts began to exercise jurisdiction over corpses and use discretion in carrying out deceased people's wishes. [41] Most countries legally treat preserved bodies as deceased persons because of laws that forbid vitrifying someone who is medically alive. [42] In France, cryonics is not considered a legal mode of body disposal; [43] only burial, cremation, and formal donation to science are allowed, though bodies may legally be shipped to other countries for cryonic freezing. [44] As of 2015, British Columbia prohibits the sale of arrangements for cryonic body preservation. [45] In Russia, cryonics falls outside both the medical industry and the funeral services industry, making it easier than in the U.S. to get hospitals and morgues to release cryonics candidates. [27]

In 2016, the English High Court ruled in favor of a mother's right to seek cryopreservation of her terminally ill 14-year-old daughter, as the girl wanted, contrary to the father's wishes. The decision was made on the basis that the case represented a conventional dispute over the disposal of the girl's body, although the judge urged ministers to seek "proper regulation" for the future of cryonic preservation after the hospital raised concerns about the competence and professionalism of the team that conducted the preservation procedures. [46] In Alcor Life Extension Foundation v. Richardson, the Iowa Court of Appeals ordered the disinterment of Richardson, who was buried against his wishes, for cryopreservation. [41] [47]

A detailed legal examination by Jochen Taupitz concludes that cryonic storage is legal in Germany for an indefinite period. [48]

Ethics

Writing in Bioethics in 2009, David Shaw examined cryonics. The arguments he cited against it included changing the concept of death, the expense of preservation and revival, lack of scientific advancement to permit revival, temptation to use premature euthanasia, and failure due to catastrophe. Arguments in favor of cryonics include the potential benefit to society, the prospect of immortality, and the benefits associated with avoiding death. Shaw explores the expense and the potential payoff, and applies an adapted version of Pascal's Wager to the question. [49] [ dubious – discuss ]

In 2016, Charles Tandy wrote in support of cryonics, arguing that honoring someone's last wishes is seen as a benevolent duty in American and many other cultures. [50]

History

Cryopreservation was applied to human cells beginning in 1954 with frozen sperm, which was thawed and used to inseminate three women. [51] The freezing of humans was first scientifically proposed by Michigan professor Robert Ettinger in The Prospect of Immortality (1962). [52] In 1966, the first human body was frozen—though it had been embalmed for two months—by being placed in liquid nitrogen and stored at just above freezing. The middle-aged woman from Los Angeles, whose name is unknown, was soon thawed and buried by relatives. [53]

The first body to be cryopreserved and then frozen in hope of future revival was that of James Bedford. Alcor's Mike Darwin says Bedford's body was cryopreserved around two hours after his death by cardiorespiratory arrest (secondary to metastasized kidney cancer) on January 12, 1967. [54] Bedford's corpse is the only one frozen before 1974 still preserved today. [53] In 1976, Ettinger founded the Cryonics Institute; his corpse was cryopreserved in 2011. [52] In 1981, Robert Nelson, "a former TV repairman with no scientific background" who led the Cryonics Society of California, was sued for allowing nine bodies to thaw and decompose in the 1970s; in his defense, he claimed that the Cryonics Society had run out of money. [53] This lowered the reputation of cryonics in the U.S. [27]

In 2018, a Y-Combinator startup called Nectome was recognized for developing a method of preserving brains with chemicals rather than by freezing. The method is fatal, performed as euthanasia under general anesthesia, but the hope is that future technology will allow the brain to be physically scanned into a computer simulation, neuron by neuron. [55]

Demographics

According to The New York Times , cryonicists are predominantly non-religious white men, outnumbering women by about three to one. [56] According to The Guardian , as of 2008, while most cryonicists used to be young, male, and "geeky", recent demographics have shifted slightly toward whole families. [42]

In 2015, Du Hong, a 61-year-old female writer of children's literature, became the first known Chinese national to have her head cryopreserved. [57]

Reception

Cryonics is generally regarded as a fringe pseudoscience. [3] The Society for Cryobiology rejected members who practiced cryonics, [3] and issued a public statement saying that cryonics is "not science". [58]

Russian company KrioRus is the first non-U.S. vendor of cryonics services. Yevgeny Alexandrov, chair of the Russian Academy of Sciences commission against pseudoscience, said there was "no scientific basis" for cryonics, and that the company was based on "unfounded speculation". [59]

Scientists have expressed skepticism about cryonics in media sources, [27] and the Norwegian philosopher Ole Martin Moen has written that the topic receives a "minuscule" amount of attention in academia. [11]

While some neuroscientists contend that all the subtleties of a human mind are contained in its anatomical structure, [60] few will comment directly on cryonics due to its speculative nature. People who intend to be frozen are often "looked at as a bunch of kooks". [61] Cryobiologist Kenneth B. Storey said in 2004 that cryonics is impossible and will never be possible, as cryonics proponents are proposing to "overturn the laws of physics, chemistry, and molecular science". [8] Neurobiologist Michael Hendricks has said, "Reanimation or simulation is an abjectly false hope that is beyond the promise of technology and is certainly impossible with the frozen, dead tissue offered by the 'cryonics' industry". [27]

Anthropologist Simon Dein writes that cryonics is a typical pseudoscience because of its lack of falsifiability and testability. In his view, cryonics is not science, but religion: it places faith in nonexistent technology and promises to overcome death. [62]

William T. Jarvis has written, "Cryonics might be a suitable subject for scientific research, but marketing an unproven method to the public is quackery". [4] [5]

According to cryonicist Aschwin de Wolf and others, cryonics can often produce intense hostility from spouses who are not cryonicists. James Hughes, the executive director of the pro-life-extension Institute for Ethics and Emerging Technologies, has not personally signed up for cryonics, calling it a worthy experiment but saying, "I value my relationship with my wife." [56]

Cryobiologist Dayong Gao has said, "People can always have hope that things will change in the future, but there is no scientific foundation supporting cryonics at this time." [39] While it is universally agreed that personal identity is uninterrupted when brain activity temporarily ceases during incidents of accidental drowning (where people have been restored to normal functioning after being completely submerged in cold water for up to 66 minutes), one argument against cryonics is that a centuries-long absence from life might interrupt personal identity, such that the revived person would "not be themself". [11]

Maastricht University bioethicist David Shaw raises the argument that there would be no point in being revived in the far future if one's friends and families are dead, leaving them all alone, but he notes that family and friends can also be frozen, that there is "nothing to prevent the thawed-out freezee from making new friends", and that a lonely existence may be preferable to none at all. [49]

In fiction

Suspended animation is a popular subject in science fiction and fantasy settings. It is often the means by which a character is transported into the future. The characters Philip J. Fry in Futurama and Khan Noonien Singh in Star Trek exemplify this trope.

A survey in Germany found that about half of the respondents were familiar with cryonics, and about half of those familiar with it had learned of it from films or television. [63]

The town of Nederland, Colorado, hosts an annual Frozen Dead Guy Days festival to commemorate a substandard attempt at cryopreservation. [64]

Notable people

Corpses subjected to the cryonics process include those of baseball players Ted Williams and his son John Henry Williams (in 2002 and 2004, respectively), [65] engineer and doctor L. Stephen Coles (in 2014), [66] economist and entrepreneur Phil Salin, and software engineer Hal Finney (in 2014). [67]

People known to have arranged for cryonics upon death include PayPal founders Luke Nosek [68] and Peter Thiel, [69] Oxford transhumanists Nick Bostrom and Anders Sandberg, and transhumanist philosopher David Pearce. [70] Larry King once arranged for cryonics but, according to Inside Edition , changed his mind. [71] [72]

Sex offender and financier Jeffrey Epstein wanted to have his head and penis frozen after death. [73] [74]

The corpses of some are mistakenly believed to have undergone cryonics. The urban legend that Walt Disney's remains were cryopreserved is false; it was cremated and interred at Forest Lawn Memorial Park Cemetery. [75] [a] Timothy Leary was a long-time cryonics advocate and signed up with a major cryonics provider, but changed his mind shortly before his death and was not cryopreserved. [77]

See also

Related Research Articles

Cryobiology is the branch of biology that studies the effects of low temperatures on living things within Earth's cryosphere or in science. The word cryobiology is derived from the Greek words κρῧος [kryos], "cold", βίος [bios], "life", and λόγος [logos], "word". In practice, cryobiology is the study of biological material or systems at temperatures below normal. Materials or systems studied may include proteins, cells, tissues, organs, or whole organisms. Temperatures may range from moderately hypothermic conditions to cryogenic temperatures.

Vitrification is the full or partial transformation of a substance into a glass, that is to say, a non-crystalline or amorphous solid. Glasses differ from liquids structurally and glasses possess a higher degree of connectivity with the same Hausdorff dimensionality of bonds as crystals: dimH = 3. In the production of ceramics, vitrification is responsible for their impermeability to water.

The Alcor Life Extension Foundation, most often referred to as Alcor, is an American nonprofit, federally tax-exempt, 501(c)(3) organization based in Scottsdale, Arizona, United States. Alcor advocates for, researches, and performs cryonics, the freezing of human corpses and brains in liquid nitrogen after legal death, with hopes of resurrecting and restoring them to full health if the technology to do so becomes available in the future. Cryonics is regarded with skepticism within the scientific community and has been characterized as quackery and pseudoscience.

21st Century Medicine (21CM) is a California cryobiological research company which has as its primary focus the development of perfusates and protocols for viable long-term cryopreservation of human organs, tissues and cells at temperatures below −100 °C through the use of vitrification. 21CM was founded in 1993.

A cryoprotectant is a substance used to protect biological tissue from freezing damage. Arctic and Antarctic insects, fish and amphibians create cryoprotectants in their bodies to minimize freezing damage during cold winter periods. Cryoprotectants are also used to preserve living materials in the study of biology and to preserve food products.

James Hiram Bedford was an American psychology professor at the University of California who wrote several books on occupational counseling. He is the first person whose body was cryopreserved after legal death, and remains preserved at the Alcor Life Extension Foundation.

Michael G. Darwin, formerly known as Michael Federowicz, is a former president of cryonics organization Alcor Life Extension Foundation. He was president from 1983 to 1988, and research director until 1992. He was also the founder and president of BioPreservation, Inc., and a cofounder, member of the board of directors, and director of research at Twenty-First Century Medicine from 1993 to 1999.

Jerry Donnell Leaf was Vice President and Director of the cryonics organization Alcor Life Extension Foundation, and President of the cryonics service firm Cryovita, Inc. until his death in 1991.

<span class="mw-page-title-main">Thomas K. Donaldson</span>

Thomas K. Donaldson was a mathematician and well-known cryonics advocate. He was born in the state of Kentucky in the United States, and took his Ph.D. from the University of Chicago in 1969. He also lived in Sunnyvale, California, and for many years in Canberra, Australia, where he taught mathematics at Australian National University. He founded both the Cryonics Association of Australia and the Institute for Neural Cryobiology, which has funded ground-breaking research in cryopreservation of brain tissue.

Saul Kent was a life extension activist, and co-founder of the Life Extension Foundation, a dietary supplement vendor and promoter of anti-aging research. He was also a pioneer in the practice of cryonics, and was a board member of the cryonics organization Alcor Life Extension Foundation.

Gregory Michael Fahy is a California-based cryobiologist, biogerontologist, and businessman. He is Vice President and Chief Scientific Officer at Twenty-First Century Medicine, Inc, and has co-founded Intervene Immune, a company developing clinical methods to reverse immune system aging. He is the 2022–2023 president of the Society for Cryobiology.

Frederick Rockwell Chamberlain III and Linda Chamberlain founded the cryonics organization Alcor Life Extension Foundation. Their long and continued history of activism in cryonics make them among the most well-known cryonics pioneers. David Pascal wrote in the November/December 2005 issue of the Mensa Bulletin that, second to the man credited with the original idea for cryonics, Robert Ettinger, the Chamberlains have contributed more than anyone to the field of cryonics.

KrioRus is the first cryonics company in Russia. It was founded in 2005 by the Russian Transhumanist Movement NGO. It is the only cryonic company in Europe to possess an own cryonic storage. The company offers the services of freezing the entire bodies or heads of clients in liquid nitrogen with a plan to revive them if such a technology is developed, but takes no legal obligations to do so.

<span class="mw-page-title-main">Oocyte cryopreservation</span> Procedure to preserve a womans eggs (oocytes)

Oocyte cryopreservation is a procedure to preserve a woman's eggs (oocytes). This technique has been used to postpone pregnancy. When pregnancy is desired, the eggs can be thawed, fertilized, and transferred to the uterus as embryos. Several studies have shown that most infertility problems are due to germ cell deterioration related to aging. The procedure's success rate varies depending on the age of the woman,, as well as depending on health and genetic indicators. In 1986, the first human birth of oocyte cryopreservation was reported.

<span class="mw-page-title-main">Cryopreservation</span> Process to preserve biological matter

Cryopreservation or cryoconservation is a process where biological material - cells, tissues, or organs - are frozen to preserve the material for an extended period of time. At low temperatures any cell metabolism which might cause damage to the biological material in question is effectively stopped. Cryopreservation is an effective way to transport biological samples over long distances, store samples for prolonged periods of time, and create a bank of samples for users. Molecules, referred to as cryoprotective agents (CPAs), are added to reduce the osmotic shock and physical stresses cells undergo in the freezing process. Some cryoprotective agents used in research are inspired by plants and animals in nature that have unique cold tolerance to survive harsh winters, including: trees, wood frogs, and tardigrades. The first human corpse to be frozen with the hope of future resurrection was James Bedford's, a few hours after his cancer-caused death in 1967.[15] Bedford's is the only cryonics corpse frozen before 1974 still frozen today.

Semen cryopreservation is a procedure to preserve sperm cells. Semen can be used successfully indefinitely after cryopreservation. It can be used for sperm donation where the recipient wants the treatment in a different time or place, or as a means of preserving fertility for men undergoing vasectomy or treatments that may compromise their fertility, such as chemotherapy, radiation therapy or surgery. It is also often used by trans women prior to medically transitioning in ways that affect fertility, such as feminizing hormone therapy and orchiectomies.

Cryopreservation of embryos is the process of preserving an embryo at sub-zero temperatures, generally at an embryogenesis stage corresponding to pre-implantation, that is, from fertilisation to the blastocyst stage.

Cryonics Institute (CI) is an American nonprofit foundation that provides cryonics services. CI freezes deceased humans and pets in liquid nitrogen with the hope of restoring them with technology in the future.

The Shandong Yinfeng Life Science Research Institute, is a life science research institute and a cryonics services provider in Jinan, Shandong, China. It was founded in 2015, and it is a division of Yinfeng Biological Group. The institute is the first organization providing cryonics services in China. In 2017, the institute stored the first cryopreserved corpse in China. The institute cryopreserves cells, tissues, human bodies, and animals, including dogs. The institute cooperates closely with the Shandong Yinfeng Life Science Foundation that funds the institute.

Aldehyde-stabilized cryopreservation is a new technique for cryopreservation first demonstrated in 2016 by Robert L. McIntyre and Gregory Fahy at the cryobiology research company 21st Century Medicine, Inc. This technique uses a particular implementation of fixation and vitrification that can successfully preserve a rabbit brain in "near perfect" condition at −135 °C, with the cell membranes, synapses, and intracellular structures intact in electron micrographs. The technique has finally won the Small Animal Brain Preservation Prize of the Brain Preservation Foundation. The cryopreserved brain was rewarmed and no serious degradation was found to have occurred; the brain structure under electron microscopic evaluation after rewarming remained well-preserved. Although this technique has not yet lead to a successful revival of a cryopreserved brain, some researchers see this technique as providing promising directions for future research.

References

Footnotes

  1. ↑ Robert Nelson told the Los Angeles Times that he thought Walt Disney wanted to be cryopreserved, for Walt Disney Studios had called him to ask detailed questions about his organisation, the Cryonics Society of California. However, Nelson clarified that "They had him cremated. I personally have seen his ashes." [76]

Citations

  1. 1 2 McKie, Robin (13 July 2002). "Cold facts about cryonics". The Observer . Archived from the original on 8 July 2017. Retrieved 1 December 2013. Cryonics, which began in the Sixties, is the freezing – usually in liquid nitrogen – of human beings who have been legally declared dead. The aim of this process is to keep such individuals in a state of refrigerated limbo so that it may become possible in the future to resuscitate them, cure them of the condition that killed them, and then restore them to functioning life in an era when medical science has triumphed over the activities of the Grim Reaper.
  2. 1 2 "Dying is the last thing anyone wants to do – so keep cool and carry on". The Guardian . 10 October 2015. Archived from the original on 3 July 2017. Retrieved 21 February 2016.
  3. 1 2 3 Steinbeck RL (29 September 2002). "Mainstream science is frosty over keeping the dead on ice". Chicago Tribune . Archived from the original on 17 July 2019. Retrieved 17 July 2019.
  4. 1 2 Butler K (1992). A Consumer's Guide to "Alternative" Medicine. Prometheus Books. p. 173.
  5. 1 2 Carroll, Robert Todd (5 December 2013). "Cryonics". The Skeptics Dictionary: A Collection of Strange Beliefs, Amusing Deceptions, and Dangerous Delusions. A business based on little more than hope for developments that can be imagined by science is quackery. There is little reason to believe that the promises of cryonics will ever be fulfilled
  6. ↑ Hendry, Robert; Crippen, David (2014). "Brain Failure and Brain Death". ACS Surgery: Principles and Practice critical care. Decker Intellectual Properties Inc. pp. 1–10. Archived from the original on 23 January 2021. Retrieved 3 March 2016. A physician will pronounce a patient using the usual cardiorespiratory criteria, whereupon the patient is legally dead. Following this pronouncement, the rules pertaining to procedures that can be performed change radically because the individual is no longer a living patient but a corpse. In the initial cryopreservation protocol, the subject is intubated and mechanically ventilated, and a highly efficient mechanical cardiopulmonary resuscitation device reestablishes circulation.
  7. ↑ Best BP (April 2008). "Scientific justification of cryonics practice" (PDF). Rejuvenation Research. 11 (2): 493–503. doi:10.1089/rej.2008.0661. PMC   4733321 . PMID   18321197. Archived from the original (PDF) on 21 July 2018. Retrieved 26 December 2013.
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  12. 1 2 Stodolsky DS (2016). "The growth and decline of cryonics". Cogent Social Sciences. 2 (1): 1167576. doi: 10.1080/23311886.2016.1167576 .
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  14. ↑ "The Alcor Patient Care Trusts" . Retrieved 18 September 2024.
  15. ↑ Doyle, DJ (2012). "Cryonic Life Extension: Scientific Possibility or Stupid Pipe Dream?". Ethics in Biology, Engineering and Medicine. 3 (1–3): 9–28. doi:10.1615/EthicsBiologyEngMed.2013006985.
  16. ↑ Germain J (21 October 2022). "200 Frozen Heads and Bodies Await Revival at This Arizona Cryonics Facility". Smithsonian Magazine.
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  18. ↑ "Frozen in time: Oregon firm preserves bodies, brains in hopes that science catches up". Portland Tribune . 18 February 2016. Archived from the original on 11 July 2017. Retrieved 21 February 2016.
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  21. 1 2 Fahy GM, Wowk B, Pagotan R, et al. (July 2009). "Physical and biological aspects of renal vitrification". Organogenesis. 5 (3): 167–75. doi:10.4161/org.5.3.9974. PMC   2781097 . PMID   20046680.
  22. ↑ Fahy GM, Wowk B, Wu J, et al. (April 2004). "Cryopreservation of organs by vitrification: perspectives and recent advances". Cryobiology. 48 (2): 157–78. doi:10.1016/j.cryobiol.2004.02.002. PMID   15094092.
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