Mark Roth (scientist)

Last updated
Mark Roth
Born1957 (age 6566)
NationalityAmerican
Alma mater University of Oregon;
University of Colorado at Boulder
SpouseLaurie Roth
Awards MacArthur Fellows Program
Scientific career
FieldsBiochemist
Institutions Fred Hutchinson Cancer Research Center

Mark Roth (born 1957) is an American biochemist, and director of the Roth Lab at the Fred Hutchinson Cancer Research Center. [1] He is a professor at the University of Washington. [2] [3]

Contents

Life

He graduated from the University of Oregon with a Bachelor of Science in 1979, and from the University of Colorado with a Doctor of Philosophy in 1984. He studies hibernation and suspended animation. This technology is not likely to be used for long term suspension of people or other mammals any time soon. [4] [5] [6] [7]

Roth spoke at the 2010 TED conference in February on using hydrogen sulfide to achieve suspended animation in humans as a means of increasing the success rate of cardiac surgery. [8] [9] The clinical trials commissioned by the company he founded, Ikaria, were however withdrawn or terminated by August 2011. [10] [11] In 2014, Roth founded Faraday Pharmaceuticals, which has produced similar trials for compounds intended to alter human metabolism. [12]

He is married to Laurie; they had two daughters and a son. [13]

Awards

Related Research Articles

<span class="mw-page-title-main">Sertindole</span> Antipsychotic medication

Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative.

<span class="mw-page-title-main">Suspended animation</span> Slowing or stopping of life without death

Suspended animation is the temporary slowing or stopping of biological function so that physiological capabilities are preserved. It may be either hypometabolic or ametabolic in nature. It may be induced by either endogenous, natural or artificial biological, chemical or physical means. In its natural form, it may be spontaneously reversible as in the case of species demonstrating hypometabolic states of hibernation. When applied with therapeutic intent, as in deep hypothermic circulatory arrest (DHCA), usually technologically mediated revival is required.

<span class="mw-page-title-main">Thiazolidinedione</span> Class of chemical compounds

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<span class="mw-page-title-main">Reperfusion injury</span> Tissue damage after return of blood supply following ischemia or hypoxia

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<span class="mw-page-title-main">Fred Hutchinson Cancer Center</span> Cancer research institute in Seattle, Washington, United States

The Fred Hutchinson Cancer Center, formerly known as the Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch, is a cancer research institute established in 1975 in Seattle, Washington.

Theralizumab is an immunomodulatory drug developed by Thomas Hünig of the University of Würzburg. It was withdrawn from development after inducing severe inflammatory reactions as well as chronic organ failure in the first-in-human study by PAREXEL in London in March 2006. The developing company, TeGenero Immuno Therapeutics, went bankrupt later that year. The commercial rights were then acquired by a Russian startup, TheraMAB. The drug was renamed TAB08. Phase I and II clinical trials have been completed for arthritis and clinical trials have been initiated for cancer.

Deep hypothermic circulatory arrest (DHCA) is a surgical technique that induces deep medical hypothermia. It involves cooling the body to temperatures between 20 °C (68 °F) to 25 °C (77 °F), and stopping blood circulation and brain function for up to one hour. It is used when blood circulation to the brain must be stopped because of delicate surgery within the brain, or because of surgery on large blood vessels that lead to or from the brain. DHCA is used to provide a better visual field during surgery due to the cessation of blood flow. DHCA is a form of carefully managed clinical death in which heartbeat and all brain activity cease.

Erika Nordby, also known as Baby Erika, Miracle Baby and Canada's Miracle Child, is a Canadian originally from Edmonton, Alberta known for having been revived after spending two hours without a heartbeat due to hypothermia. Nordby, then a 13-month-old toddler, had left her heated house nearly naked, while the air temperature was −24 °C (−11 °F).

<span class="mw-page-title-main">HIV Vaccine Trials Network</span>

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LabKey Server is a software suite available for scientists to integrate, analyze, and share biomedical research data. The platform provides a secure data repository that allows web-based querying, reporting, and collaborating across a range of data sources. Specific scientific applications and workflows can be added on top of the basic platform and leverage a data processing pipeline.

Herpes simplex research includes all medical research that attempts to prevent, treat, or cure herpes, as well as fundamental research about the nature of herpes. Examples of particular herpes research include drug development, vaccines and genome editing. HSV-1 and HSV-2 are commonly thought of as oral and genital herpes respectively, but other members in the herpes family include chickenpox (varicella/zoster), cytomegalovirus, and Epstein-Barr virus. There are many more virus members that infect animals other than humans, some of which cause disease in companion animals or have economic impacts in the agriculture industry.

Regeneration in humans is the regrowth of lost tissues or organs in response to injury. This is in contrast to wound healing, or partial regeneration, which involves closing up the injury site with some gradation of scar tissue. Some tissues such as skin, the vas deferens, and large organs including the liver can regrow quite readily, while others have been thought to have little or no capacity for regeneration following an injury.

Hydrogen sulfide is produced in small amounts by some cells of the mammalian body and has a number of biological signaling functions. Only two other such gases are currently known: nitric oxide (NO) and carbon monoxide (CO).

Steven Henikoff is a scientist at the Fred Hutchinson Cancer Research Center, and an HHMI Investigator. His field of study is chromatin-related transcriptional regulation. He earned his BS in chemistry at the University of Chicago. He earned his PhD in biochemistry and molecular biology from Harvard University in the lab of Matt Meselson in 1977. He did a postdoctoral fellowship at the University of Washington. His research has been funded by the National Science Foundation, National Institutes of Health, and HHMI. In 1992, Steven Henikoff, together with his wife Jorja Henikoff, introduced the BLOSUM substitution matrices. The BLOSUM matrices are widely used for sequence alignment of proteins. In 2005, Henikoff was elected to the National Academy of Sciences.

<span class="mw-page-title-main">Lobucavir</span> Chemical compound

Lobucavir is an antiviral drug that shows broad-spectrum activity against herpesviruses, hepatitis B and other hepadnaviruses, HIV/AIDS and cytomegalovirus. It initially demonstrated positive results in human clinical trials against hepatitis B with minimal adverse effects but was discontinued from further development following the discovery of increased risk of cancer associated with long-term use in mice. Although this carcinogenic risk is present in other antiviral drugs, such as zidovudine and ganciclovir that have been approved for clinical use, development was halted by Bristol-Myers Squibb, its manufacturer.

Stephanie J. Lee is an American haematologist and physician scientist who is Professor and Associate Director at the Fred Hutchinson Cancer Research Center. Lee works to improve the lives of blood stem cell transplant and bone marrow patients by better understanding the chronic form of graft-versus-host disease. Lee is the former President of the American Society of Hematology.

Deborah J. Donnell is a New Zealand and American biostatistician known for her research on the prevention of HIV infection. She is a professor in the Vaccine and Infectious Disease Division and Public Health Sciences Division of the Fred Hutchinson Cancer Research Center, and an affiliate professor of global health and health services at the University of Washington.

Julie M. Overbaugh is an American virologist. She is a professor at the Fred Hutchinson Cancer Research Center. Overbaugh is best known for her translational approach to studying HIV transmission and pathogenesis and studies of how the antibody response evolves to recognize viruses. Her work in maternal and infant HIV transmission helped make clear the risk posed by breastfeeding and highlighted unique characteristics of an infant immune response that could inform vaccine development. Major scientific contributions to the understanding of HIV transmission and pathogenesis also include: identifying a bottleneck that selects one or a few variants during HIV transmission; demonstrating the importance of female hormones in HIV infection risk; showing the HIV reinfection is common; demonstrating a role for antibodies that mediate ADCC in clinical disease; showing that HIV infected infants develop unique neutralizing antibody responses to HIV.

Amanda Grace Paulovich is an oncologist, and a pioneer in proteomics using multiple reaction monitoring mass spectrometry to study tailored cancer treatment.

References

  1. "Roth Lab". Archived from the original on 2016-11-18. Retrieved 2010-03-27.
  2. "COS Expertise - A Knowledge Management System". Archived from the original on 2011-06-14. Retrieved 2010-03-27.
  3. Administrator. "Columns Magazine - The University of Washington Alumni Magazine". Archived from the original on 2017-02-08. Retrieved 2010-03-27.
  4. "Mark Roth, Spontaneous Combustion and Hibernation - Dear Science".
  5. Paulson, Tom (2005-04-21). "Fred Hutch scientists induce hibernation in mice". Seattle Post-Intelligencer.
  6. Stein, Rob (2005-04-22). "State of Hibernation Is Induced in Mice". The Washington Post.
  7. "Welcome to NWS&T Magazine Online, "Ikaria Seeks To Unlock Secrets Of Suspended Animation For Medical Benefit"".
  8. "TED Talk: Mark Roth Says Suspended Animation Could Soon Be a Reality". 2010-03-19.
  9. "Mark Roth: Suspended animation is within our grasp".
  10. "IK-1001 (Sodium Sulfide (Na2S) for Injection) in Subjects With Acute ST-Segment Elevation Myocardial Infarction". ClinicalTrials.gov. 2010-11-04. This study has been withdrawn prior to enrollment. ( Company decision. Non-safety related )
  11. "Reduction of Ischemia-Reperfusion Mediated Cardiac Injury in Subjects Undergoing Coronary Artery Bypass Graft Surgery". ClinicalTrials.gov. 2011-08-03. This study has been terminated. ( Study Terminated - Company decision )
  12. "Scientists-turned-entrepreneurs share lessons learned launching startups". fredhutch.org. 2018-03-26.
  13. Tom Junod (2 December 2008). "Mark Roth's Proof of Reincarnation - Scientist Bringing Back the Dead". Esquire.
  14. http://www.macfound.org/site/c.lkLXJ8MQKrH/b.2913825/apps/nl/content2.asp?content_id={901B69E7-3C10-41E9-AEE1-D7C6B61A2C1B}&notoc=1 Archived 2012-03-15 at the Wayback Machine
  15. "News Releases". Fred Hutch.