Guillermina Lozano

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Guillermina Lozano
Alma mater Pan American University (BSc)
Rutgers University (PhD)
Scientific career
Institutions University of Texas MD Anderson Cancer Center
Thesis Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide (1986)

Guillermina 'Gigi' Lozano is an American geneticist. She is a professor at University of Texas MD Anderson Cancer Center. Lozano is recognised for her studies of the p53 tumour suppressor pathway, characterising the protein as a regulator of gene expression (transcription factor).

Contents

Early life and education

Lozano was born in East Chicago, Indiana, the daughter of Mexican immigrants. She attended a private Catholic high school, Bishop Noll, up until her senior year, when her family moved to McAllen, Texas. [1]

Lozano completed a Bachelor of Science in biology and mathematics, graduating Magna Cum Laude, at Pan American University (now University of Texas Rio Grande Valley) in 1979. She earned a doctor of philosophy in biochemistry from Rutgers University and University of Medicine and Dentistry of New Jersey in 1986. [2] Lozano's dissertation was titled Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide. [3] She completed postgraduate training in molecular biology at Princeton University from 1985 to 1987. [2]

Career and research

Lozano is Professor and Chair of the Department of Genetics [4] at University of Texas MD Anderson Cancer Center. She is also a professor at University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. [2]

Lozano is recognised for her studies of the p53 [5] tumour suppressor pathway, from characterising p53 as a transcriptional activator [6] to revealing the importance of two inhibitors of p53, Mdm2 and Mdm4. Her lab has generated dozens of mouse models of p53 to explore effects of mutations in this tumor-suppressing protein on tumorogeneis. [7]

Awards and honours

Lozano is a member of the National Academy of Sciences, [8] National Academy of Medicine, [9] Academy of Medicine, Engineering and Science of Texas. [2]

Awards:

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References

  1. ↑ Hardy, Michael. "Her discovery expanded our knowledge of cancer genetics". MD Anderson Cancer Center. Retrieved 2023-02-21.
  2. 1 2 3 4 "Guillermina (Gigi) Lozano". MD Anderson Cancer Center. Retrieved 2018-12-10.
  3. ↑ Lozano, Guillermina (1986). "Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide". ProQuest Dissertations Publishing. Rutgers The State University of New Jersey.{{cite journal}}: Cite journal requires |journal= (help)
  4. ↑ "Guillermina (Gigi) Lozano". MD Anderson Cancer Center. Retrieved 2022-02-11.
  5. ↑ Moyer, Sydney M.; Wasylishen, Amanda R.; Qi, Yuan; Fowlkes, Natalie; Su, Xiaoping; Lozano, Guillermina (2020-09-22). "p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo". Proceedings of the National Academy of Sciences. 117 (38): 23663–23673. Bibcode:2020PNAS..11723663M. doi: 10.1073/pnas.2008474117 . ISSN   0027-8424. PMC   7519296 . PMID   32900967.
  6. ↑ "Transcriptional Activation by Wild-Type But Not Transforming Mutants of the p53 Anti-Oncogene", Science 31 August 1990
  7. ↑ Jeffers, John R.; Pinto, Emilia M.; Rehg, Jerold E.; Clay, Michael R.; Wang, Jinling; Neale, Geoffrey; Heath, Richard J.; Lozano, Guillermina; Lalli, Enzo; Figueiredo, Bonald C.; Pappo, Alberto S. (2021-05-01). "The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model". Cancer Research. 81 (9): 2442–2456. doi:10.1158/0008-5472.CAN-20-1750. ISSN   0008-5472. PMC   8137600 . PMID   33637564.
  8. 1 2 "Guillermina Lozano". www.nasonline.org. Retrieved 2022-02-11.
  9. ↑ "Member". National Academy of Medicine. Retrieved 2022-02-11.
  10. ↑ "Guillermina (Gigi) Lozano, PhD". American Association for Cancer Research (AACR). Retrieved 2022-02-11.
  11. ↑ "Guillermina Lozano". American Academy of Arts & Sciences. Retrieved 2022-02-11.
  12. ↑ "E.E. Just Lecture", American Society for Cell Biology
  13. ↑ "Guillermina Lozano Member Directory", National Academy of Sciences
  14. ↑ "AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Recipients", American Association for Cancer Research
  15. ↑ "AACR-Minorities in Cancer Research Jane Cooke Wright Memorial Lectureship Recipients", American Association for Cancer Research
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