H2AFB2

H2AB2
Identifiers
Aliases	H2AB2 , H2A.Bbd, H2A histone family member B2, H2A.B variant histone 2, H2AFB2, H2AB3
External IDs	MGI: 3644875 HomoloGene: 129517 GeneCards: H2AB2
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 155,380,709 bp [1] End 155,381,299 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X E2 Start 120,312,748 bp [2] End 120,313,095 bp [2]
Gene ontology Molecular function • protein heterodimerization activity • DNA binding Cellular component • nucleosome • transcriptionally active chromatin • nucleus • chromosome Biological process • nucleosome assembly • mRNA processing • chromatin silencing • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	474381	624957
Ensembl	ENSG00000277858	ENSMUSG00000083616
UniProt	P0C5Z0	S4R1G7
RefSeq (mRNA)	NM_001017991	NM_001281531
RefSeq (protein)	NP_001017991	NP_001268460
Location (UCSC)	Chr X: 155.38 – 155.38 Mb	Chr X: 120.31 – 120.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1). ^[5]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000277858 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000083616 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: H2A histone family".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chadwick BP, Willard HF (2001). "A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome". J. Cell Biol. 152 (2): 375–84. doi:10.1083/jcb.152.2.375. PMC   2199617 . PMID   11266453.
• Bao Y, Konesky K, Park YJ, et al. (2004). "Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA". EMBO J. 23 (16): 3314–24. doi:10.1038/sj.emboj.7600316. PMC   514500 . PMID   15257289.
• Naylor JA, Buck D, Green P, et al. (1995). "Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions". Hum. Mol. Genet. 4 (7): 1217–24. doi:10.1093/hmg/4.7.1217. PMID   8528212.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.