H2AFJ

H2AJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EDU
Identifiers
Aliases	H2AJ , H2A histone family member J, H2AFJ, H2A.J histone
External IDs	MGI: 3606192 HomoloGene: 128575 GeneCards: H2AJ
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p12.3 Start 14,774,383 bp [1] End 14,778,002 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G1 Start 136,808,244 bp [2] End 136,810,074 bp [2]
Gene ontology Molecular function • protein heterodimerization activity • DNA binding • molecular function Cellular component • extracellular exosome • chromosome • nucleosome • nucleus Biological process • chromatin silencing • chromatin organization • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55766	232440
Ensembl	ENSG00000246705	ENSMUSG00000060032
UniProt	Q9BTM1	Q8R1M2
RefSeq (mRNA)	NM_018267 NM_177925	NM_177688
RefSeq (protein)	NP_808760	NP_808356
Location (UCSC)	Chr 12: 14.77 – 14.78 Mb	Chr 6: 136.81 – 136.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene. ^[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000246705 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060032 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: H2AFJ H2A histone family, member J".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC   291826 . PMID   14657027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi: 10.1006/viro.2001.1129 . PMID   11689053.
• Chadwick BP, Willard HF (2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum. Mol. Genet. 10 (10): 1101–13. doi: 10.1093/hmg/10.10.1101 . PMID   11331621.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi: 10.1006/viro.2000.0593 . PMID   11080476.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC   110633 . PMID   9566873.