H2AFY2

MACROH2A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XD7
Identifiers
Aliases	MACROH2A2 , macroH2A2, H2A histone family member Y2, H2AFY2, macroH2A.2 histone
External IDs	OMIM: 616141; MGI: 3037658; HomoloGene: 10246; GeneCards: MACROH2A2; OMA:MACROH2A2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.1 Start 70,052,544 bp [1] End 70,112,282 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 B4 Start 61,574,444 bp [2] End 61,619,926 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone epithelium of colon gingival epithelium cerebellar vermis pancreatic epithelial cell islet of Langerhans epithelium of esophagus hair follicle cerebellar hemisphere Top expressed in genital tubercle tail of embryo neural tube ventricular zone maxillary prominence ganglionic eminence mandibular prominence medial ganglionic eminence otic placode abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein heterodimerization activity chromatin DNA binding Cellular component ESC/E(Z) complex nucleoplasm chromosome nucleosome chromatin extracellular exosome Barr body nucleus Biological process nucleosome assembly negative regulation of transcription of nucleolar large rRNA by RNA polymerase I positive regulation of keratinocyte differentiation dosage compensation negative regulation of transcription by RNA polymerase II establishment of protein localization to chromatin brain development negative regulation of gene expression, epigenetic regulation of cell growth chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55506 404634 Ensembl ENSG00000099284 ENSMUSG00000020086 UniProt Q9P0M6 Q8CCK0 RefSeq (mRNA) NM_018649 NM_207000 RefSeq (protein) NP_061119 NP_996883 Location (UCSC) Chr 10: 70.05 – 70.11 Mb Chr 10: 61.57 – 61.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000099284 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020086 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet. 10 (10): 1101–13. doi: 10.1093/hmg/10.10.1101 . PMID   11331621.
6. Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem. 276 (24): 21776–84. doi: 10.1074/jbc.M010919200 . PMID   11262398.
7. "Entrez Gene: H2AFY2 H2A histone family, member Y2".

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC   110633 . PMID   9566873.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi: 10.1006/viro.2000.0593 . PMID   11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi: 10.1006/viro.2001.1129 . PMID   11689053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC   291826 . PMID   14657027.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Dev. Cell. 8 (1): 19–30. doi: 10.1016/j.devcel.2004.10.019 . PMID   15621527.