Hyaluronan and proteoglycan link protein 1 is a protein that in humans is encoded by the HAPLN1 gene. [5] [6] [7]
Hyaluronan and proteoglycan link protein 1 is a protein that in humans is encoded by the HAPLN1 gene. [5] [6] [7]
Glycosaminoglycans (GAGs) or mucopolysaccharides are long linear polysaccharides consisting of repeating disaccharide units. The repeating two-sugar unit consists of a uronic sugar and an amino sugar, with the exception of keratan, where in the place of the uronic sugar it has galactose. Because GAGs are highly polar and attract water, they are used in the body as a lubricant or shock absorber. Mucopolysaccharidoses are a group of metabolic disorders in which abnormal accumulations of glycosaminoglycans occur because of enzyme deficiencies.
Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.
Decorin is a protein that in humans is encoded by the DCN gene.
Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.
The sulfate transporter is a solute carrier family protein that in humans is encoded by the SLC26A2 gene. SLC26A2 is also called the diastrophic dysplasia sulfate transporter (DTDST), and was first described by Hästbacka et al. in 1994. This sulfate (SO42−) transporter also accepts chloride, hydroxyl ions (OH−), and oxalate as substrates. SLC26A2 is expressed at high levels in developing and mature cartilage, as well as being expressed in lung, placenta, colon, kidney, pancreas and testis.
Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.
A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.
Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.
Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.
Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells, and is the only known intracellular proteoglycan.
Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.
Proteoglycan 4 or lubricin is a proteoglycan that in humans is encoded by the PRG4 gene. It acts as a joint/boundary lubricant.
U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.
Fibromodulin is a protein that in humans is encoded by the FMOD gene.
Brevican core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein family.
Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 gene.
Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.
Tenascin-R is a protein that in humans is encoded by the TNR gene.
Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene. HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.
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