HARS

Last updated
HARS1
Protein HARS PDB 1x59.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HARS1 , HRS, USH3B, CMT2W, histidyl-tRNA synthetase, HARS, histidyl-tRNA synthetase 1
External IDs OMIM: 142810; MGI: 108087; HomoloGene: 1592; GeneCards: HARS1; OMA:HARS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008214

RefSeq (protein)

NP_032240

Location (UCSC) Chr 5: 140.67 – 140.69 Mb Chr 18: 36.9 – 36.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene. [5] [6]

Contents

Function

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. [7] The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. [5]

Clinical significance

The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. [7]

Interactions

HARS has been shown to interact with EEF1B2 [8] and EEF1G. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170445 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001380 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: HARS histidyl-tRNA synthetase".
  6. Wasmuth JJ, Carlock LR (1986). "Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5". Somat. Cell Mol. Genet. 12 (5): 513–7. doi:10.1007/BF01539922. PMID   3464104. S2CID   28520231.
  7. 1 2 Freist W, Verhey JF, Rühlmann A, Gauss DH, Arnez JG (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi: 10.1515/BC.1999.079 . PMID   10430027.
  8. 1 2 Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID   11829477.

Further reading