HARS2

HARS2
Identifiers
Aliases	HARS2 , HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial, HisRS
External IDs	OMIM: 600783 MGI: 1918041 HomoloGene: 40819 GeneCards: HARS2
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 140,691,430 bp [1] End 140,699,305 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B2 Start 36,783,008 bp [2] End 36,792,562 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • ligase activity • GO:0001948 protein binding • ATP binding • protein homodimerization activity • histidine-tRNA ligase activity • RNA binding • identical protein binding Cellular component • cytoplasm • mitochondrial matrix • mitochondrion • cytosol Biological process • protein biosynthesis • histidyl-tRNA aminoacylation • mitochondrial translation • tRNA aminoacylation for protein translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23438	70791
Ensembl	ENSG00000112855	ENSMUSG00000019143
UniProt	P49590	Q99KK9
RefSeq (mRNA)	NM_001278731 NM_001278732 NM_012208 NM_001363535 NM_001363536	NM_080636 NM_001305627 NM_001360921
RefSeq (protein)	NP_001265660 NP_001265661 NP_036340 NP_001350464 NP_001350465	NP_001292556 NP_542367 NP_001347850
Location (UCSC)	Chr 5: 140.69 – 140.7 Mb	Chr 18: 36.78 – 36.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene. ^{[5] [6]}

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000112855 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019143 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. O'Hanlon TP, Raben N, Miller FW (Jun 1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS". Biochem Biophys Res Commun. 210 (2): 556–66. doi:10.1006/bbrc.1995.1696. PMID   7755634.
6. "Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)".

Further reading

• Freist W, Verhey JF, Rühlmann A, et al. (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi: 10.1515/BC.1999.079 . PMID   10430027.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lama J, Trono D (1998). "Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3". J. Virol. 72 (2): 1671–6. doi:10.1128/JVI.72.2.1671-1676.1998. PMC   124654 . PMID   9445076.
• Tsui HW, Mok S, de Souza L, et al. (1993). "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element". Gene. 131 (2): 201–8. doi:10.1016/0378-1119(93)90294-D. PMID   8406012.
• Raben N, Borriello F, Amin J, et al. (1992). "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases". Nucleic Acids Res. 20 (5): 1075–81. doi:10.1093/nar/20.5.1075. PMC   312093 . PMID   1549469.