HAT1

HAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P0W
Identifiers
Aliases	HAT1 , KAT1, histone acetyltransferase 1
External IDs	OMIM: 603053; MGI: 96013; HomoloGene: 2701; GeneCards: HAT1; OMA:HAT1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q31.1 Start 171,922,448 bp [1] End 171,983,686 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C2 Start 71,219,302 bp [2] End 71,271,966 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone biceps brachii Skeletal muscle tissue of rectus abdominis palpebral conjunctiva amniotic fluid Skeletal muscle tissue of biceps brachii mucosa of paranasal sinus bronchial epithelial cell cartilage tissue Top expressed in spermatid Gonadal ridge epiblast primitive streak tail of embryo embryo maxillary prominence mandibular prominence medial ganglionic eminence somite More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity histone binding H4 histone acetyltransferase activity histone acetyltransferase activity protein binding acyltransferase activity Cellular component cytoplasm intracellular membrane-bounded organelle nuclear matrix nucleoplasm nucleus protein-containing complex Biological process response to nutrient internal protein amino acid acetylation DNA replication-dependent chromatin assembly histone acetylation histone H4 acetylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8520 107435 Ensembl ENSG00000128708 ENSMUSG00000027018 UniProt O14929 Q8BY71 RefSeq (mRNA) NM_001033085 NM_003642 NM_026115 RefSeq (protein) NP_003633 NP_080391 Location (UCSC) Chr 2: 171.92 – 171.98 Mb Chr 2: 71.22 – 71.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone acetyltransferase 1, also known as HAT1, is an enzyme that, in humans, is encoded by the HAT1 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000128708 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027018 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998). "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase". Curr. Biol. 8 (2): 96–108. Bibcode:1998CBio....8...96V. doi: 10.1016/S0960-9822(98)70040-5 . PMID   9427644. S2CID   201273.
6. "Entrez Gene: histone acetyltransferase 1".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Benson LJ, Phillips JA, Gu Y, et al. (2007). "Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair". J. Biol. Chem. 282 (2): 836–42. doi: 10.1074/jbc.M607464200 . PMID   17052979.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Makowski AM, Dutnall RN, Annunziato AT (2001). "Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase". J. Biol. Chem. 276 (47): 43499–502. doi: 10.1074/jbc.C100549200 . PMID   11585814.
• Marmorstein R (2001). "Structure of histone acetyltransferases". J. Mol. Biol. 311 (3): 433–44. doi:10.1006/jmbi.2001.4859. PMID   11492997.
• Miyamoto N, Izumi H, Noguchi T, et al. (2008). "Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance". J. Biol. Chem. 283 (26): 18218–26. doi: 10.1074/jbc.M802332200 . PMID   18458078.
• Cheung P, Tanner KG, Cheung WL, et al. (2000). "Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation". Mol. Cell. 5 (6): 905–15. doi: 10.1016/S1097-2765(00)80256-7 . PMID   10911985.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Grönroos E, Hellman U, Heldin CH, Ericsson J (2002). "Control of Smad7 stability by competition between acetylation and ubiquitination". Mol. Cell. 10 (3): 483–93. doi: 10.1016/S1097-2765(02)00639-1 . PMID   12408818.
• Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID   12775419. S2CID   22016092.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID   11329013. S2CID   25064683.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.