HAT1

HAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P0W
Identifiers
Aliases	HAT1 , KAT1, histone acetyltransferase 1
External IDs	OMIM: 603053 MGI: 96013 HomoloGene: 2701 GeneCards: HAT1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	171,983,686 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,271,966 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; palpebral conjunctiva; ; amniotic fluid; ; bronchial epithelial cell; ; spongy bone; ; islet of Langerhans; ; vastus lateralis muscle; ; Achilles tendon; ; secondary oocyte; ; gastrocnemius muscle;
	Top expressed in
	spermatid; ; primitive streak; ; maxillary prominence; ; medial ganglionic eminence; ; somite; ; abdominal wall; ; yolk sac; ; cumulus cell; ; dermis; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; histone binding ; H4 histone acetyltransferase activity ; histone acetyltransferase activity ; protein binding ; acyltransferase activity ;
Cellular component	cytoplasm ; intracellular membrane-bounded organelle ; nuclear matrix ; nucleoplasm ; nucleus ; protein-containing complex ;
Biological process	response to nutrient ; internal protein amino acid acetylation ; DNA replication-dependent chromatin assembly ; histone acetylation ; histone H4 acetylation ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	8520
	107435
	ENSG00000128708
	ENSMUSG00000027018
	O14929
	Q8BY71
	NM_001033085 ; NM_003642
	NM_026115
	NP_003633
	NP_080391
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 01, 2024

Histone acetyltransferase 1, also known as HAT1, is an enzyme that, in humans, is encoded by the HAT1 gene.^[5]^[6]

Function

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5.^[6]

Related Research Articles

<span class="mw-page-title-main">Histone acetyltransferase</span> Enzymes that catalyze acyl group transfer from acetyl-CoA to histones

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.

Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.

DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.

Histone H2A type 2-C is a protein that in humans is encoded by the HIST2H2AC gene.

Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AM gene.

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AK gene.

Histone H2A type 1-H is a protein that in humans is encoded by the HIST1H2AH gene.

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene.

Histone H4 is a protein that in humans is encoded by the HIST1H4F gene.

K(lysine) acetyltransferase 8 (KAT8) is an enzyme that in humans is encoded by the KAT8 gene.

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.

Histone H2A type 2-B is a protein that in humans is encoded by the HIST2H2AB gene.

Histone H4 is a protein that in humans is encoded by the HIST1H4D gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128708 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027018 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998). "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase". Curr. Biol. 8 (2): 96–108. Bibcode:1998CBio....8...96V. doi: 10.1016/S0960-9822(98)70040-5 . PMID 9427644. S2CID 201273.
1 2 "Entrez Gene: histone acetyltransferase 1".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Benson LJ, Phillips JA, Gu Y, et al. (2007). "Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair". J. Biol. Chem. 282 (2): 836–42. doi: 10.1074/jbc.M607464200 . PMID 17052979.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Makowski AM, Dutnall RN, Annunziato AT (2001). "Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase". J. Biol. Chem. 276 (47): 43499–502. doi: 10.1074/jbc.C100549200 . PMID 11585814.
Marmorstein R (2001). "Structure of histone acetyltransferases". J. Mol. Biol. 311 (3): 433–44. doi:10.1006/jmbi.2001.4859. PMID 11492997.
Miyamoto N, Izumi H, Noguchi T, et al. (2008). "Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance". J. Biol. Chem. 283 (26): 18218–26. doi: 10.1074/jbc.M802332200 . PMID 18458078.
Cheung P, Tanner KG, Cheung WL, et al. (2000). "Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation". Mol. Cell. 5 (6): 905–15. doi: 10.1016/S1097-2765(00)80256-7 . PMID 10911985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Grönroos E, Hellman U, Heldin CH, Ericsson J (2002). "Control of Smad7 stability by competition between acetylation and ubiquitination". Mol. Cell. 10 (3): 483–93. doi: 10.1016/S1097-2765(02)00639-1 . PMID 12408818.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128708 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027018 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Verreault_1998-5] Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998). "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase". Curr. Biol. 8 (2): 96–108. Bibcode:1998CBio....8...96V. doi: 10.1016/S0960-9822(98)70040-5 . PMID 9427644. S2CID 201273.

[entrez-6] 1 2 "Entrez Gene: histone acetyltransferase 1".

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HAT1

Contents

Function

Related Research Articles

References

Further reading