HAUS1

HAUS1
Identifiers
Aliases	HAUS1 , CCDC5, HEI-C, HEIC, HsT1461, HAUS augmin like complex subunit 1
External IDs	OMIM: 608775 MGI: 2385076 HomoloGene: 15516 GeneCards: HAUS1
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	77,767,780 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; monocyte; ; stromal cell of endometrium; ; rectum; ; Achilles tendon; ; smooth muscle tissue; ; bone marrow; ; gallbladder; ; lymph node; ; appendix;
	Top expressed in
	spermatid; ; spermatocyte; ; yolk sac; ; testicle; ; blastocyst; ; bone marrow; ; lens; ; morula; ; quadriceps femoris muscle; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; molecular function ;
Cellular component	microtubule organizing center ; centrosome ; spindle ; spindle pole ; microtubule ; HAUS complex ; cytoskeleton ; cytoplasm ; cytosol ;
Biological process	spindle assembly ; cell cycle ; cell division ; G2/M transition of mitotic cell cycle ; ciliary basal body-plasma membrane docking ; centrosome cycle ; regulation of G2/M transition of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	115106
	225745
	n/a
	ENSMUSG00000041840
	Q96CS2
	Q8BHX1
	NM_138443
	NM_146089 ; NM_001357531 ; NM_001357532 ; NM_001357533
	NP_612452
	NP_666201 ; NP_001344460 ; NP_001344461 ; NP_001344462
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 01, 2024

HAUS augmin-like complex subunit 1 is a protein that in humans is encoded by the HAUS1 gene.^[4]^[5]^[6]

Related Research Articles

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Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

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DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.

60S ribosomal protein L9 is a protein that in humans is encoded by the RPL9 gene.

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.

Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene.

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.

WASH complex subunit 3, formerly known as coiled-coil domain-containing protein 53 (CCDC53), is a protein that in humans is encoded by the WASHC3 gene.

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

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References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041840 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
↑ Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, et al. (May 2009). "HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity". Curr Biol. 19 (10): 816–26. Bibcode:2009CBio...19..816L. doi: 10.1016/j.cub.2009.04.033 . PMID 19427217. S2CID 2893122.
↑ "Entrez Gene: CCDC5 coiled-coil domain containing 5 (spindle associated)".

External links

Human HAUS1 genome location and HAUS1 gene details page in the UCSC Genome Browser .

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Einarson MB, Cukierman E, Compton DA, Golemis EA (2004). "Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis". Mol. Cell. Biol. 24 (9): 3957–71. doi:10.1128/MCB.24.9.3957-3971.2004. PMC 387757 . PMID 15082789.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, et al. (2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. Bibcode:2004Sci...305...86R. doi:10.1126/science.1097639. PMID 15232106. S2CID 20936301.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041840 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-4] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

[pmid19427217-5] Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, et al. (May 2009). "HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity". Curr Biol. 19 (10): 816–26. Bibcode:2009CBio...19..816L. doi: 10.1016/j.cub.2009.04.033 . PMID 19427217. S2CID 2893122.

[entrez-6] "Entrez Gene: CCDC5 coiled-coil domain containing 5 (spindle associated)".

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HAUS1

Contents

Related Research Articles

References

External links

Further reading