HCLS1

HCLS1
Identifiers
Aliases	HCLS1 , CTTNL, HS1, lckBP1, p75, hematopoietic cell-specific Lyn substrate 1
External IDs	OMIM: 601306; MGI: 104568; HomoloGene: 38034; GeneCards: HCLS1; OMA:HCLS1 - orthologs
Gene location (Mouse) Chr. Chromosome 16 (mouse) [1] Band 16|16 B3 Start 36,755,345 bp [1] End 36,783,574 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen appendix bone marrow cells lymph node right lung trabecular bone upper lobe of left lung gallbladder Top expressed in granulocyte mesenteric lymph nodes thymus spleen neural layer of retina bone marrow stroma of bone marrow ankle joint tibiofemoral joint blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding actin binding protein kinase binding protein-containing complex binding Cellular component cytoplasm membrane transcription regulator complex mitochondrion nucleus cytosol plasma membrane Biological process positive regulation of protein kinase B signaling intracellular signal transduction regulation of transcription, DNA-templated positive regulation of tyrosine phosphorylation of STAT protein positive regulation of macrophage differentiation negative regulation of transcription by RNA polymerase II cellular response to cytokine stimulus positive regulation of peptidyl-serine phosphorylation regulation of actin filament polymerization actin filament polymerization positive regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of granulocyte differentiation erythrocyte differentiation negative regulation of leukocyte apoptotic process response to hormone positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of actin cytoskeleton reorganization positive regulation of transcription by RNA polymerase II positive regulation of protein import into nucleus positive regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3059 15163 Ensembl n/a ENSMUSG00000022831 UniProt P14317 P49710 RefSeq (mRNA) NM_005335 NM_001292041 NM_008225 RefSeq (protein) NP_001278970 NP_005326 NP_032251 Location (UCSC) n/a Chr 16: 36.76 – 36.78 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene. ^{[4] [5] [6]}

Interactions

HCLS1 has been shown to interact with Caspase 3. ^{[7] [8]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000022831 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 175–6. doi:10.1159/000134179. PMID   8978766.
5. van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics. 6: 15. doi: 10.1186/1471-2164-6-15 . PMC   554100 . PMID   15710041.
6. "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
7. Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1). England: 41–7. doi:10.1042/bj3640041. ISSN   0264-6021. PMC   1222543 . PMID   11988074.
8. Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4). United States: 981–9. doi:10.1006/bbrc.2001.5862. ISSN   0006-291X. PMID   11689006.

Further reading

• Kitamura D, Kaneko H, Miyagoe Y, et al. (1990). "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage". Nucleic Acids Res. 17 (22): 9367–79. PMC   335138 . PMID   2587259.
• Yamanashi Y, Okada M, Semba T, et al. (1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3631–5. Bibcode:1993PNAS...90.3631Y. doi: 10.1073/pnas.90.8.3631 . PMC   46355 . PMID   7682714.
• Hata D, Nakamura T, Kawakami T, et al. (1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking". Immunol. Lett. 40 (1): 65–71. doi:10.1016/0165-2478(94)90208-9. PMID   7927516.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Egerton M, Moritz RL, Druker B, et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes". Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID   8713105.
• Suzuki Y, Demoliere C, Kitamura D, et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases". J. Immunol. 158 (6): 2736–44. doi: 10.4049/jimmunol.158.6.2736 . PMID   9058808. S2CID   25584050.
• Yamanashi Y, Fukuda T, Nishizumi H, et al. (1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis". J. Exp. Med. 185 (7): 1387–92. doi:10.1084/jem.185.7.1387. PMC   2196252 . PMID   9104825.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Brunati AM, Donella-Deana A, James P, et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase". J. Biol. Chem. 274 (11): 7557–64. doi: 10.1074/jbc.274.11.7557 . PMID   10066823.
• Nagata Y, Kiefer F, Watanabe T, Todokoro K (1999). "Activation of hematopoietic progenitor kinase-1 by erythropoietin". Blood. 93 (10): 3347–54. doi:10.1182/blood.V93.10.3347.410k06_3347_3354. PMID   10233887.
• Takemoto Y, Furuta M, Sato M, et al. (2000). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3". Int. Immunol. 11 (12): 1957–64. doi: 10.1093/intimm/11.12.1957 . PMID   10590261.
• Ruzzene M, Brunati AM, Sarno S, et al. (2000). "Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2". Eur. J. Biochem. 267 (10): 3065–72. doi:10.1046/j.1432-1033.2000.01333.x. PMID   10806407.
• Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID   11689006.
• Ruzzene M, Penzo D, Pinna LA (2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1): 41–7. doi:10.1042/bj3640041. PMC   1222543 . PMID   11988074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi: 10.1073/pnas.2436191100 . PMC   141014 . PMID   12522270.
• Uruno T, Zhang P, Liu J, et al. (2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization". Biochem. J. 371 (Pt 2): 485–93. doi:10.1042/BJ20021791. PMC   1223309 . PMID   12534372.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.