HEXIM1

HEXIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GD7, 3S9G
Identifiers
Aliases	HEXIM1 , CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1
External IDs	OMIM: 607328; MGI: 2385923; HomoloGene: 31382; GeneCards: HEXIM1; OMA:HEXIM1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 45,148,475 bp [1] End 45,152,099 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E1 Start 103,007,057 bp [2] End 103,010,551 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte middle temporal gyrus gingival epithelium germinal epithelium kidney tubule glomerulus Brodmann area 23 placenta metanephric glomerulus amniotic fluid Top expressed in gastrula median eminence adrenal gland transitional epithelium of urinary bladder lateral geniculate nucleus ascending aorta granulocyte medial geniculate nucleus ciliary body central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding snRNA binding 7SK snRNA binding cyclin-dependent protein serine/threonine kinase inhibitor activity Cellular component nucleoplasm cytoplasm nucleus Biological process positive regulation of signal transduction by p53 class mediator heart development regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II activation of innate immune response immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10614 192231 Ensembl ENSG00000186834 ENSMUSG00000048878 UniProt O94992 Q8R409 RefSeq (mRNA) NM_006460 NM_138753 RefSeq (protein) NP_006451 NP_620092 Location (UCSC) Chr 17: 45.15 – 45.15 Mb Chr 11: 103.01 – 103.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene. ^{[5] [6] [7]}

Interactions

HEXIM1 has been shown to interact with Cyclin T1 ^[6] and Cdk9 ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000186834 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048878 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huang F, Wagner M, Siddiqui MA (Jul 2002). "Structure, expression, and functional characterization of the mouse CLP-1 gene". Gene. 292 (1–2): 245–59. doi:10.1016/S0378-1119(02)00596-6. PMID   12119119.
6. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (Jun 2003). "MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner". Mol Cell Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC   162212 . PMID   12832472.
7. "Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1".
8. Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O (October 2016). "An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb". Proc Natl Acad Sci U S A. 113 (45): 12721–6. Bibcode:2016PNAS..11312721K. doi: 10.1073/pnas.1612331113 . PMC   5111705 . PMID   27791144.

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Ohsuzu F, Tanaka H (2003). "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells". Genes Cells. 8 (2): 95–107. doi: 10.1046/j.1365-2443.2003.00618.x . PMID   12581153. S2CID   21478049.
• Wittmann BM, Wang N, Montano MM (2003). "Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors". Cancer Res. 63 (16): 5151–8. PMID   12941847.
• Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q (2003). "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA". Mol. Cell. 12 (4): 971–82. doi: 10.1016/S1097-2765(03)00388-5 . PMID   14580347.
• Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi: 10.1016/S0092-8674(04)00342-3 . PMID   15109492. S2CID   16049289.
• Yik JH, Chen R, Pezda AC, Samford CS, Zhou Q (2004). "A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb". Mol. Cell. Biol. 24 (12): 5094–105. doi:10.1128/MCB.24.12.5094-5105.2004. PMC   419863 . PMID   15169877.
• Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O (2005). "Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor". EMBO J. 23 (13): 2608–19. doi:10.1038/sj.emboj.7600275. PMC   449783 . PMID   15201869.
• Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription". J. Biol. Chem. 280 (16): 16368–76. doi: 10.1074/jbc.M500912200 . PMID   15713661.
• Byers SA, Price JP, Cooper JJ, Li Q, Price DH (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK". J. Biol. Chem. 280 (16): 16360–7. doi: 10.1074/jbc.M500424200 . PMID   15713662.
• Schulte A, Czudnochowski N, Barboric M, Schönichen A, Blazek D, Peterlin BM, Geyer M (2005). "Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat". J. Biol. Chem. 280 (26): 24968–77. doi: 10.1074/jbc.M501431200 . PMID   15855166.
• Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM (2005). "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1". Oncogene. 24 (36): 5576–88. doi: 10.1038/sj.onc.1208728 . PMID   15940264.
• Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H (2005). "HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8555–60. Bibcode:2005PNAS..102.8555S. doi: 10.1073/pnas.0409863102 . PMC   1150813 . PMID   15941832.
• Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186". J. Biol. Chem. 280 (31): 28819–26. doi: 10.1074/jbc.M502712200 . PMID   15965233.
• Fraldi A, Varrone F, Napolitano G, Michels AA, Majello B, Bensaude O, Lania L (2006). "Inhibition of Tat activity by the HEXIM1 protein". Retrovirology. 2: 42. doi: 10.1186/1742-4690-2-42 . PMC   1183248 . PMID   15992410.
• Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O (2005). "Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer". J. Biol. Chem. 280 (34): 30619–29. doi: 10.1074/jbc.M502471200 . PMID   15994294.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.