HIF1AN

HIF1AN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H2K, 1H2L, 1H2M, 1H2N, 1IZ3, 1MZE, 1MZF, 1YCI, 2CGN, 2CGO, 2ILM, 2W0X, 2WA3, 2WA4, 2XUM, 2Y0I, 2YC0, 2YDE, 3D8C, 3KCX, 3KCY, 3OD4, 3P3N, 3P3P, 4AI8, 4B7E, 4B7K, 4BIO, 4JAA, 4NR1, 4Z2W, 4Z1V
Identifiers
Aliases	HIF1AN , FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
External IDs	OMIM: 606615; MGI: 2442345; HomoloGene: 9906; GeneCards: HIF1AN; OMA:HIF1AN - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.31 Start 100,529,072 bp [1] End 100,559,998 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 44,551,289 bp [2] End 44,564,713 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle Skeletal muscle tissue of rectus abdominis muscle of thigh glutes tendon of biceps brachii stromal cell of endometrium triceps brachii muscle quadriceps femoris muscle vastus lateralis muscle islet of Langerhans Top expressed in muscle of thigh knee joint skeletal muscle tissue triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle tibialis anterior muscle temporal muscle digastric muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding peptidyl-asparagine 3-dioxygenase activity protein homodimerization activity ankyrin repeat binding zinc ion binding dioxygenase activity metal ion binding NF-kappaB binding Notch binding protein binding carboxylic acid binding oxidoreductase activity peptidyl-histidine dioxygenase activity oxygen gasoreceptor activity 2-oxoglutarate-dependent dioxygenase activity hypoxia-inducible factor-asparagine oxygenase activity Cellular component cytoplasm nucleoplasm perinuclear region of cytoplasm nucleus cytosol Biological process regulation of transcription, DNA-templated peptidyl-histidine hydroxylation transcription, DNA-templated peptidyl-aspartic acid hydroxylation peptidyl-asparagine hydroxylation positive regulation of myoblast differentiation positive regulation of vasculogenesis regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55662 319594 Ensembl ENSG00000166135 ENSMUSG00000036450 UniProt Q9NWT6 Q8BLR9 RefSeq (mRNA) NM_017902 NM_176958 RefSeq (protein) NP_060372 NP_795932 Location (UCSC) Chr 10: 100.53 – 100.56 Mb Chr 19: 44.55 – 44.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene. ^{[5] [6]}

Interactions

FIH has been shown to interact with HIF1A ^[5] and Von Hippel-Lindau tumor suppressor. ^[5] Additionally, asparaginyl hydroxylation of HIF1α by FIH-1 (HIF1AN) at N803 impairs its interaction with CBP/P300. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000166135 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036450 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mahon PC, Hirota K, Semenza GL (Oct 2001). "FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity". Genes Dev. 15 (20): 2675–86. doi:10.1101/gad.924501. PMC   312814 . PMID   11641274.
6. "Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor".
7. Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): 46691–703. doi:10.18632/oncotarget.17358. PMC   5542303 . PMID   28493839.

Further reading

• Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. Bibcode:2002Sci...295..858L. doi:10.1126/science.1068592. PMID   11823643. S2CID   24045310.
• Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ (2002). "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5367–72. Bibcode:2002PNAS...99.5367F. doi: 10.1073/pnas.082117899 . PMC   122775 . PMID   11959990.
• Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ (2002). "Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family". J. Biol. Chem. 277 (29): 26351–5. doi: 10.1074/jbc.C200273200 . PMID   12042299.
• Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002). "FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor". Genes Dev. 16 (12): 1466–71. doi:10.1101/gad.991402. PMC   186346 . PMID   12080085.
• Dann CE, Bruick RK, Deisenhofer J (2003). "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway". Proc. Natl. Acad. Sci. U.S.A. 99 (24): 15351–6. doi: 10.1073/pnas.202614999 . PMC   137720 . PMID   12432100.
• Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ (2003). "Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha". J. Biol. Chem. 278 (3): 1802–6. doi: 10.1074/jbc.C200644200 . PMID   12446723.
• Lee C, Kim SJ, Jeong DG, Lee SM, Ryu SE (2003). "Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau". J. Biol. Chem. 278 (9): 7558–63. doi: 10.1074/jbc.M210385200 . PMID   12482756.
• Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J (2004). "Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases". J. Biol. Chem. 279 (11): 9899–904. doi: 10.1074/jbc.M312254200 . PMID   14701857.
• Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ (2004). "Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor". J. Biol. Chem. 279 (14): 14391–7. doi: 10.1074/jbc.M313614200 . PMID   14734545.
• Kato H, Tamamizu-Kato S, Shibasaki F (2004). "Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity". J. Biol. Chem. 279 (40): 41966–74. doi: 10.1074/jbc.M406320200 . PMID   15280364.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ (2006). "Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14767–72. Bibcode:2006PNAS..10314767C. doi: 10.1073/pnas.0606877103 . PMC   1578504 . PMID   17003112.
• Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ (2007). "Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor". J. Biol. Chem. 282 (33): 24027–38. doi: 10.1074/jbc.M704102200 . PMID   17573339.
• Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): 46691–703. doi: 10.18632/oncotarget.17358 . PMC   5542303 . PMID   28493839.