HMCES

HMCES
Identifiers
Aliases	HMCES , C3orf37, SRAPD1, DC12, 5-hydroxymethylcytosine (hmC) binding, ES cell-specific, 5-hydroxymethylcytosine binding, ES cell specific
External IDs	OMIM: 618288; MGI: 1914053; HomoloGene: 6636; GeneCards: HMCES; OMA:HMCES - orthologs
EC number	3.4.-.-
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q21.3 Start 129,278,828 bp [1] End 129,306,186 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 87,890,917 bp [2] End 87,913,611 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans gastrocnemius muscle ventricular zone ganglionic eminence mucosa of transverse colon muscle of thigh lymph node apex of heart secondary oocyte left testis Top expressed in zygote primary oocyte secondary oocyte embryo tail of embryo yolk sac ventricular zone granulocyte genital tubercle right kidney More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 56941 232210 Ensembl ENSG00000183624 ENSMUSG00000030060 UniProt Q96FZ2 Q8R1M0 RefSeq (mRNA) NM_001006109 NM_020187 NM_001363881 NM_001370343 NM_001370344 NM_001370345 NM_173737 RefSeq (protein) NP_001006109 NP_064572 NP_001350810 NP_001357272 NP_001357273 NP_001357274 NP_776098 Location (UCSC) Chr 3: 129.28 – 129.31 Mb Chr 6: 87.89 – 87.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

5-hydroxymethylcytosine binding, ES cell specific is a protein that in humans is encoded by the HMCES gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000183624 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030060 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: 5-hydroxymethylcytosine binding, ES cell specific" . Retrieved 2018-05-16.

Further reading

• Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M (June 2014). "Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain". Neurobiol. Aging. 35 (6): 1334–44. doi:10.1016/j.neurobiolaging.2013.11.031. PMID   24387984. S2CID   25277574.
• Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, Mill J, Lunnon K (August 2014). "Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain". Neurobiol. Aging. 35 (8): 1850–4. doi:10.1016/j.neurobiolaging.2014.02.002. PMC   4066184 . PMID   24679604.
• Kraus TF, Guibourt V, Kretzschmar HA (July 2015). "5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing". J Neural Transm (Vienna). 122 (7): 1035–43. doi:10.1007/s00702-014-1346-4. PMID   25471351. S2CID   34905929.
• Zhang LY, Li PL, Wang TZ, Zhang XC (October 2015). "Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer". Arch. Gynecol. Obstet. 292 (4): 891–7. doi:10.1007/s00404-015-3704-3. PMID   25827305. S2CID   24483457.
• Biayna, Josep; Garcia-Cao, Isabel; Álvarez, Miguel M.; Salvadores, Marina; Espinosa-Carrasco, Jose; McCullough, Marcel; Supek, Fran; Stracker, Travis H. (2021-03-31). "Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells". PLOS Biology. 19 (3) e3001176. doi: 10.1371/journal.pbio.3001176 . PMC   8041192 . PMID   33788831.