HMGXB4

HMGXB4
Identifiers
Aliases	HMGXB4 , Hmgxb4, 4733401K04Rik, AI316803, E430025G12, Hmgb2l1, HMG2L1, HMGBCG, THC211630, HMG-box containing 4, P53N
External IDs	OMIM: 604702 MGI: 1918073 HomoloGene: 4007 GeneCards: HMGXB4
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,295,807 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,758,606 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sperm; ; sural nerve; ; placenta; ; tibia; ; bone marrow; ; urethra; ; nipple; ; embryo;
	Top expressed in
	secondary oocyte; ; primitive streak; ; medullary collecting duct; ; morula; ; blastocyst; ; ganglionic eminence; ; maxillary prominence; ; yolk sac; ; vas deferens; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ;
Cellular component	NURF complex ; nucleus ;
Biological process	negative regulation of Wnt signaling pathway ; Wnt signaling pathway ; endosome to lysosome transport ;
	Sources:Amigo / QuickGO
Orthologs
	10042
	70823
	ENSG00000100281
	ENSMUSG00000034518
	Q9UGU5
	n/a
	NM_001003681 ; NM_005487 ; NM_014250 ; NM_001362972
	NM_178017 ; NM_001316753 ; NM_001316754
	NP_001003681 ; NP_001349901
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

HMG-box containing 4 is a protein that in humans is encoded by the HMGXB4 gene. ^[5]

Function

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010].

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100281 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034518 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: HMG-box containing 4" . Retrieved 2017-11-17.

Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi: 10.1002/ajmg.b.30574 . PMID 17671966.
Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi: 10.1002/ajmg.b.30574 . PMID 17671966.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Zhou J, Hu G, Wang X (2010). "Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1". J. Biol. Chem. 285 (30): 23177–85. doi: 10.1074/jbc.M110.109868 . PMC 2906311 . PMID 20511232.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100281 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034518 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HMG-box containing 4" . Retrieved 2017-11-17.

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HMGXB4

Contents

Function

Related Research Articles

References

Further reading