HP1BP3

HP1BP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RQP
Identifiers
Aliases	HP1BP3 , HP1-BP74, HP1BP74, heterochromatin protein 1 binding protein 3
External IDs	OMIM: 616072; MGI: 109369; HomoloGene: 7774; GeneCards: HP1BP3; OMA:HP1BP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.12 Start 20,742,679 bp [1] End 20,787,323 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D3 Start 137,943,607 bp [2] End 137,971,994 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 ventricular zone tibia trabecular bone parietal pleura visceral pleura skin of hip Achilles tendon parotid gland seminal vesicula Top expressed in renal corpuscle medullary collecting duct ventricular zone condyle ascending aorta aortic valve neural layer of retina ganglionic eminence vestibular membrane of cochlear duct thymus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleosome binding protein binding chromatin binding Cellular component nucleosome nucleus chromosome nuclear speck Biological process regulation of nucleus size nucleosome assembly heterochromatin organization regulation of transcription, DNA-templated regulation of cell population proliferation cellular response to hypoxia Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50809 15441 Ensembl ENSG00000127483 ENSMUSG00000028759 UniProt Q5SSJ5 Q3TEA8 RefSeq (mRNA) NM_016287 NM_001372052 NM_001122896 NM_001122897 NM_001285478 NM_001285479 NM_001285480 NM_001285481 NM_010470 NM_001356431 NM_001356432 RefSeq (protein) NP_057371 NP_001358981 NP_001363716 NP_001363717 NP_001363718 NP_001363719 NP_001363720 NP_001363721 NP_001363722 NP_001363723 NP_001363724 NP_001363725 NP_001363726 NP_001116368 NP_001116369 NP_001272407 NP_001272408 NP_001272409 NP_001272410 NP_034600 NP_001343360 NP_001343361 Location (UCSC) Chr 1: 20.74 – 20.79 Mb Chr 4: 137.94 – 137.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene. ^[5] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin ^{[6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000127483 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028759 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: heterochromatin protein 1, binding protein 3" . Retrieved 2011-08-30.
6. Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J (February 2015). "HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth". Nucleic Acids Research. 43 (4): 2074–90. doi:10.1093/nar/gkv089. PMC   4344522 . PMID   25662603.
7. Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK (September 2014). "Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression". Molecular & Cellular Proteomics. 13 (9): 2183–97. doi: 10.1074/mcp.M113.034975 . PMC   4159643 . PMID   24830416.
8. Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi: 10.1074/jbc.M109.092833 . PMC   2825445 . PMID   20042602.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.
• Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (April 2009). "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex". Molecular Cell. 34 (2): 145–54. doi:10.1016/j.molcel.2009.03.013. PMC   2727917 . PMID   19394292.
• Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW (April 2009). "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia". European Archives of Psychiatry and Clinical Neuroscience. 259 (3): 151–63. doi:10.1007/s00406-008-0847-2. PMID   19165527. S2CID   33815571.
• Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–9. Bibcode:2010MRFMM.694...13F. doi:10.1016/j.mrfmmm.2010.08.006. PMID   20800603.
• Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi: 10.1074/jbc.M109.092833 . PMC   2825445 . PMID   20042602.
• Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW (2009). "In vitro nuclear interactome of the HIV-1 Tat protein". Retrovirology. 6 47. doi: 10.1186/1742-4690-6-47 . PMC   2702331 . PMID   19454010.