HSD17B7

HSD17B7
Identifiers
Aliases	HSD17B7 , PRAP, SDR37C1, hydroxysteroid (17-beta) dehydrogenase 7, hydroxysteroid 17-beta dehydrogenase 7
External IDs	OMIM: 606756; MGI: 1330808; HomoloGene: 40728; GeneCards: HSD17B7; OMA:HSD17B7 - orthologs
EC number	1.1.1.62
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.3 Start 162,790,702 bp [1] End 162,812,823 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H3 Start 169,777,104 bp [2] End 169,796,810 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex anterior pituitary C1 segment upper lobe of left lung islet of Langerhans ectocervix Top expressed in vestibular sensory epithelium skin of external ear Paneth cell ciliary body facial motor nucleus condyle hair follicle substantia nigra iris medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity estradiol 17-beta-dehydrogenase activity 3-keto sterol reductase activity Cellular component integral component of membrane plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process estrogen biosynthetic process cholesterol biosynthetic process lipid metabolism steroid biosynthetic process nervous system development cell differentiation embryonic skeletal system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51478 15490 Ensembl ENSG00000132196 ENSMUSG00000026675 UniProt P56937 O88736 RefSeq (mRNA) NM_001304512 NM_001304513 NM_016371 NM_010476 RefSeq (protein) NP_001291441 NP_001291442 NP_057455 NP_034606 Location (UCSC) Chr 1: 162.79 – 162.81 Mb Chr 1: 169.78 – 169.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene. ^{[5] [6] [7] [8]}

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM] ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000132196 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026675 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J (Dec 1999). "Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)". FEBS Lett. 460 (2): 373–9. doi: 10.1016/S0014-5793(99)01366-6 . PMID   10544267. S2CID   11558347.
6. Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P (Aug 1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7". J Steroid Biochem Mol Biol. 69 (1–6): 431–9. doi:10.1016/S0960-0760(99)00064-3. PMID   10419022. S2CID   25448122.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
8. "Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7".

Further reading

• Mendoza-Hernández G, Rendón JL, Díaz-Zagoya JC (1985). "A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta". Biochem. Biophys. Res. Commun. 126 (1): 477–81. doi:10.1016/0006-291X(85)90630-8. PMID   3855619.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Törn S, Nokelainen P, Kurkela R, et al. (2003). "Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7". Biochem. Biophys. Res. Commun. 305 (1): 37–45. doi:10.1016/S0006-291X(03)00694-6. PMID   12732193.
• Marijanovic Z, Laubner D, Moller G, et al. (2004). "Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis". Mol. Endocrinol. 17 (9): 1715–25. doi:10.1210/me.2002-0436. PMID   12829805.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ohnesorg T, Adamski J (2005). "Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7". J. Steroid Biochem. Mol. Biol. 94 (1–3): 259–61. doi:10.1016/j.jsbmb.2005.01.012. PMID   15862973. S2CID   46113625.
• Ohnesorg T, Adamski J (2006). "Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region". Mol. Cell. Endocrinol. 248 (1–2): 164–7. doi:10.1016/j.mce.2005.10.016. PMID   16356630. S2CID   8896905.
• Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J (2007). "Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis". J. Mol. Endocrinol. 37 (1): 185–97. doi: 10.1677/jme.1.02043 . PMID   16901934.
• Smuc T, Pucelj MR, Sinkovec J, et al. (2007). "Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis". Gynecol. Endocrinol. 23 (2): 105–11. doi:10.1080/09513590601152219. PMID   17454161. S2CID   41842764.
• Guggenberger C, Ilgen D, Adamski J (2007). "Functional analysis of cholesterol biosynthesis by RNA interference". J. Steroid Biochem. Mol. Biol. 104 (3–5): 105–9. doi:10.1016/j.jsbmb.2007.03.001. PMID   17498944. S2CID   20838858.