HSD17B8

HSD17B8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PD6, 4CQL, 4CQM
Identifiers
Aliases	HSD17B8 , D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8
External IDs	OMIM: 601417 MGI: 95911 HomoloGene: 56588 GeneCards: HSD17B8
EC number	1.1.1.239
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,206,831 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,247,034 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right lobe of liver; ; right uterine tube; ; right adrenal gland; ; kidney; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; skin of abdomen; ; salivary gland; ; minor salivary gland;
	Top expressed in
	adrenal gland; ; proximal tubule; ; islet of Langerhans; ; kidney; ; white adipose tissue; ; bone marrow; ; urinary bladder; ; muscle tissue; ; hepatobiliary system; ; liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; estradiol 17-beta-dehydrogenase activity ; protein binding ; testosterone dehydrogenase (NAD+) activity ; 3-hydroxyacyl-CoA dehydrogenase activity ; 3-oxoacyl-[acyl-carrier-protein reductase (NADH) activity]; NADH binding ; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ;
Cellular component	plasma membrane ; mitochondrial envelope ; membrane ; mitochondrion ; mitochondrial matrix ;
Biological process	estrogen biosynthetic process ; estrogen metabolic process ; androgen metabolic process ; fatty acid metabolic process ; lipid metabolism ; steroid biosynthetic process ; fatty acid biosynthetic process ; protein heterotetramerization ; fatty-acyl-CoA biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	7923
	14979
ENSG00000204228 ; ENSG00000228357 ; ENSG00000225312 ; ENSG00000232357 ; ENSG00000112474 ;
	ENSG00000228712
	ENSMUSG00000073422
	Q92506
	P50171
	NM_014234
	NM_013543
	NP_055049
	NP_038571
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 03, 2024

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.^[5]^[6]^[7]

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.^[7]

Related Research Articles

<span class="mw-page-title-main">11β-Hydroxysteroid dehydrogenase type 1</span> Mammalian protein found in Homo sapiens

11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It belongs to the family of short-chain dehydrogenases. It is encoded by the HSD11B1 gene.

17β-Hydroxysteroid dehydrogenases, also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol.

In enzymology, a 3-hydroxyisobutyrate dehydrogenase also known as β-hydroxyisobutyrate dehydrogenase or 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) is an enzyme that in humans is encoded by the HIBADH gene.

17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto group of androgens and estrogens and hence is able to regulate the potency of these sex steroids

HSD3B1 is a human gene that encodes for a 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. While it can carry out the same function as HSD3B2, it localizes primarily to different tissues, such as the placenta and nonsteroidogenic tissues. Its requirement for the production of progesterone by the placenta, which has a vital role in pregnancy, may be one reason why no disease based on mutations in this gene has been identified to date, besides prostate cancer.

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by the HSD17B10 gene. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Human HSD10 cDNA was cloned from the brain (NM_004493), and the resulting protein, a homotetramer, was first characterized as a short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). Active sites of this enzyme can accommodate different substrates; 17β-HSD10 is involved in the oxidation of isoleucine, branched-chain fatty acids, and xenobiotics as well as the metabolism of sex hormones and neuroactive steroids.

D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV is a protein that in humans is encoded by the HSD17B4 gene. It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and steroid metabolism.

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating is an enzyme that in humans is encoded by the NSDHL gene. This enzyme is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis.

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene.

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.

Retinol dehydrogenase 12 is an enzyme that in humans is encoded by the RDH12 gene.

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.

Dehydrogenase/reductase SDR family member 9 is an enzyme that in humans is encoded by the DHRS9 gene.

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene.

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.

References

1 2 3 ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 GRCh38: Ensembl release 89: ENSG00000204228, ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073422 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics. 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.
1 2 "Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8".

Kikuti YY, Tamiya G, Ando A, et al. (1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes". Genomics. 42 (3): 422–35. doi:10.1006/geno.1997.4745. PMID 9205114.
Fomitcheva J, Baker ME, Anderson E, et al. (1998). "Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues". J. Biol. Chem. 273 (35): 22664–71. doi: 10.1074/jbc.273.35.22664 . PMID 9712896.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Aziz N, Anderson E, Lee GY, Woo DD (2001). "Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism". Mol. Cell. Endocrinol. 171 (1–2): 83–8. doi:10.1016/S0303-7207(00)00390-7. PMID 11165015. S2CID 20566396.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748 . PMID 12136098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Song D, Liu G, Luu-The V, et al. (2006). "Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study". J. Steroid Biochem. Mol. Biol. 101 (2–3): 136–44. doi:10.1016/j.jsbmb.2006.06.015. PMID 16930994. S2CID 27619774.
Villar J, Celay J, Alonso MM, et al. (2007). "Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta". J. Steroid Biochem. Mol. Biol. 105 (1–5): 131–9. doi:10.1016/j.jsbmb.2006.12.106. PMID 17583490. S2CID 54404567.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 GRCh38: Ensembl release 89: ENSG00000204228, ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073422 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812499-5] Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics. 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.

[entrez-7] 1 2 "Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8".

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HSD17B8

Related Research Articles

References

Further reading