HSPA13

HSPA13
Identifiers
Aliases	HSPA13 , STCH, heat shock protein family A (Hsp70) member 13
External IDs	OMIM: 601100 MGI: 1309463 HomoloGene: 5062 GeneCards: HSPA13
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q11.2 Start 14,371,115 bp [1] End 14,383,484 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 C3.1|16 43.36 cM Start 75,542,319 bp [2] End 75,563,992 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans ganglionic eminence endothelial cell corpus epididymis retinal pigment epithelium caput epididymis orbitofrontal cortex Brodmann area 23 Region I of hippocampus proper superior frontal gyrus Top expressed in hand lacrimal gland seminal vesicula superior cervical ganglion otolith organ arcuate nucleus median eminence utricle cumulus cell dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding ATPase activity heat shock protein binding protein folding chaperone activity unfolded protein binding misfolded protein binding Cellular component extracellular exosome endoplasmic reticulum intracellular membrane-bounded organelle nucleus cytoplasm endoplasmic reticulum lumen membrane endoplasmic reticulum chaperone complex Biological process response to unfolded protein ubiquitin-dependent ERAD pathway endoplasmic reticulum unfolded protein response cellular response to heat Unfolded Protein Response protein refolding chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6782 110920 Ensembl ENSG00000155304 ENSMUSG00000032932 UniProt P48723 Q8BM72 RefSeq (mRNA) NM_006948 NM_030201 RefSeq (protein) NP_008879 NP_084477 Location (UCSC) Chr 21: 14.37 – 14.38 Mb Chr 16: 75.54 – 75.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heat shock 70 kDa protein 13 is a protein that in humans is encoded by the HSPA13 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with endoplasmic reticulum. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000155304 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032932 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brodsky G, Otterson GA, Parry BB, Hart I, Patterson D, Kaye FJ (Feb 1997). "Localization of STCH to human chromosome 21q11.1". Genomics. 30 (3): 627–8. doi:10.1006/geno.1995.1291. PMID   8825657.
6. "HSPA13 heat shock protein family A (Hsp70) member 13 [ Homo sapiens (human) ]".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Otterson GA, Flynn GC, Kratzke RA, et al. (1994). "Stch encodes the 'ATPase core' of a microsomal stress 70 protein". EMBO J. 13 (5): 1216–25. doi:10.1002/j.1460-2075.1994.tb06371.x. PMC   394931 . PMID   8131751.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Kaye FJ, Modi S, Ivanovska I, et al. (2000). "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch". FEBS Lett. 467 (2–3): 348–55. doi: 10.1016/S0014-5793(00)01135-2 . PMID   10675567. S2CID   11514284.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID   12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Aoki M, Yamamoto K, Ohyama S, et al. (2005). "A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population". Biochem. Biophys. Res. Commun. 335 (2): 566–74. doi:10.1016/j.bbrc.2005.07.110. PMID   16087163.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.