IARS

For other uses, see IARS (disambiguation).

IARS1
Identifiers
Aliases	IARS1 , isoleucyl-tRNA synthetase 1, ILERS, isoleucyl-tRNA synthetase, PRO0785, GRIDHH, IRS, ILRS, IARS
External IDs	OMIM: 600709 MGI: 2145219 HomoloGene: 5325 GeneCards: IARS1
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.31 Start 92,210,207 bp [1] End 92,293,756 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A5 Start 49,835,576 bp [2] End 49,887,743 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis middle temporal gyrus caput epididymis right ventricle cavity of mouth spongy bone Brodmann area 23 stromal cell of endometrium tibia gums Top expressed in motor neuron secondary oocyte primitive streak lacrimal gland seminal vesicula somite condyle Paneth cell abdominal wall maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity protein binding GTPase binding ATP binding aminoacyl-tRNA editing activity tRNA binding isoleucine-tRNA ligase activity Cellular component membrane extracellular exosome cytoplasm aminoacyl-tRNA synthetase multienzyme complex cytosol Biological process protein biosynthesis tRNA aminoacylation for protein translation osteoblast differentiation regulation of translational fidelity isoleucyl-tRNA aminoacylation aminoacyl-tRNA metabolism involved in translational fidelity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3376 105148 Ensembl ENSG00000196305 ENSMUSG00000037851 UniProt P41252 Q6P0M4 Q8BU30 RefSeq (mRNA) NM_002161 NM_013417 NM_001374299 NM_001374300 NM_001374301 NM_172015 RefSeq (protein) NP_002152 NP_038203 NP_001361228 NP_001361229 NP_001361230 NP_001365498 NP_001365500 NP_001365501 NP_001365502 NP_001365503 NP_001365504 NP_001365505 NP_001365506 NP_001365507 NP_001365508 NP_001365509 NP_001365511 NP_001365512 NP_001365513 NP_001365514 NP_001365515 NP_002152.2 NP_742012 Location (UCSC) Chr 9: 92.21 – 92.29 Mb Chr 13: 49.84 – 49.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Isoleucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the IARS1 gene. ^{[5] [6]}

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs. ^[6]

Interactions

IARS has been shown to interact with EPRS. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000196305 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037851 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nichols RC, Blinder J, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P (February 1997). "Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24". Genomics. 36 (1): 210–3. doi:10.1006/geno.1996.0449. PMID   8812440.
6. "Entrez Gene: IARS1 isoleucyl-tRNA synthetase".
7. Rho, S B; Lee J S; Jeong E J; Kim K S; Kim Y G; Kim S (May 1998). "A multifunctional repeated motif is present in human bifunctional tRNA synthetase". J. Biol. Chem. UNITED STATES. 273 (18): 11267–73. doi: 10.1074/jbc.273.18.11267 . ISSN   0021-9258. PMID   9556618.

Further reading

• Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". J. Biol. Chem. 266 (23): 15398–405. doi: 10.1016/S0021-9258(18)98629-1 . PMID   1651330.
• Nichols RC, Raben N, Boerkoel CF, Plotz PH (1995). "Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension". Gene. 155 (2): 299–304. doi:10.1016/0378-1119(94)00634-5. PMID   7721108.
• Shiba K, Suzuki N, Shigesada K, et al. (1994). "Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit". Proc. Natl. Acad. Sci. U.S.A. 91 (16): 7435–9. Bibcode:1994PNAS...91.7435S. doi: 10.1073/pnas.91.16.7435 . PMC   44415 . PMID   8052601.
• Rho SB, Lee KH, Kim JW, et al. (1996). "Interaction between human tRNA synthetases involves repeated sequence elements". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10128–33. Bibcode:1996PNAS...9310128R. doi: 10.1073/pnas.93.19.10128 . PMC   38348 . PMID   8816763.
• Degoul F, Brulé H, Cepanec C, et al. (1998). "Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene". Hum. Mol. Genet. 7 (3): 347–54. doi: 10.1093/hmg/7.3.347 . PMID   9466989.
• Rho SB, Lee JS, Jeong EJ, et al. (1998). "A multifunctional repeated motif is present in human bifunctional tRNA synthetase". J. Biol. Chem. 273 (18): 11267–73. doi: 10.1074/jbc.273.18.11267 . PMID   9556618.
• Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID   9878398.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.