IFI30

IFI30
Identifiers
Aliases	IFI30 , GILT, IFI-30, IP30, IP-30, lysosomal thiol reductase, IFI30 lysosomal thiol reductase
External IDs	OMIM: 604664 MGI: 2137648 HomoloGene: 38171 GeneCards: IFI30
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 18,173,162 bp [1] End 18,178,117 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.3 Start 71,215,419 bp [2] End 71,219,307 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood appendix spleen upper lobe of left lung right lung lymph node duodenum placenta gallbladder Top expressed in spleen duodenum colon yolk sac jejunum stomach ileum thymus zone of skin lip More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein binding oxidoreductase activity, acting on a sulfur group of donors Cellular component extracellular region cell junction lysosomal lumen intracellular membrane-bounded organelle lysosome cytosol Biological process interferon-gamma-mediated signaling pathway immune system process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class I Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10437 65972 Ensembl ENSG00000216490 ENSMUSG00000031838 UniProt P13284 Q9ESY9 RefSeq (mRNA) NM_006332 NM_023065 RefSeq (protein) NP_006323 NP_075552 Location (UCSC) Chr 19: 18.17 – 18.18 Mb Chr 8: 71.22 – 71.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000216490 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031838 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. doi: 10.1016/S0021-9258(18)37889-X . PMID   3136170.
6. Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. Bibcode:2000PNAS...97..745A. doi: 10.1073/pnas.97.2.745 . PMC   15401 . PMID   10639150.
7. "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

Further reading

• Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet. 20 (1): 1. PMID   16170.
• Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association. 52 (1): 9. PMID   1069150.
• Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. doi: 10.1074/jbc.M003459200 . PMID   10852914.
• Phan UT, Maric M, Dick TP, Cresswell P (2001). "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics. 53 (4): 342–6. doi:10.1007/s002510100323. PMID   11491538. S2CID   848449.
• Haque MA, Li P, Jackson SK, et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMC   2193747 . PMID   12021307.
• Phan UT, Lackman RL, Cresswell P (2002). "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. Bibcode:2002PNAS...9912298P. doi: 10.1073/pnas.182430499 . PMC   129439 . PMID   12198183.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.