IFIT2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | IFIT2 , G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2, ISG-54 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 147040 MGI: 99449 HomoloGene: 1187 GeneCards: IFIT2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 is a protein found in humans which is encoded by the IFIT2 gene. [5] [6] [7]
IFIT2 may play a role in prevention of tumor progression. [8] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [9] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [9]
Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.
Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include potentiation of Interferon gamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized proteins and negative regulation of the IFN-I response.
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.
Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.
Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.
Interferon gamma receptor 1 (IFNGR1) also known as CD119, is a protein that in humans is encoded by the IFNGR1 gene.
Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.
Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene.
N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.
Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.
DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.
Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.
Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. IFITM1 has also recently been designated CD225. This protein has several additional names: fragilis, IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.
Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene.
Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.
Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2 gene.
Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.
Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.
Interferon-induced protein with tetratricopeptide repeats 3 is a protein that in humans is encoded by the IFIT3 gene.