IFIT2

IFIT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4G1T
Identifiers
Aliases	IFIT2 , G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2, ISG-54
External IDs	OMIM: 147040; MGI: 99449; HomoloGene: 1187; GeneCards: IFIT2; OMA:IFIT2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,309,271 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,553,819 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; inferior ganglion of vagus nerve; ; trigeminal ganglion; ; subthalamic nucleus; ; visceral pleura; ; white blood cell; ; monocyte; ; external globus pallidus; ; parietal pleura; ; spinal ganglia;
	Top expressed in
	iris; ; mammillary body; ; lumbar spinal ganglion; ; decidua; ; endothelial cell of lymphatic vessel; ; blood; ; ciliary body; ; sciatic nerve; ; medial geniculate nucleus; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; RNA binding ;
Cellular component	cytoplasm ; cytosol ; endoplasmic reticulum ;
Biological process	apoptotic process ; positive regulation of apoptotic process ; response to virus ; innate immune response ; defense response to virus ; negative regulation of protein binding ; apoptotic mitochondrial changes ; type I interferon signaling pathway ; cellular response to interferon-alpha ; immune system process ;
	Sources:Amigo / QuickGO
Orthologs
	3433
	15958
	ENSG00000119922
	ENSMUSG00000045932
	P09913
	Q64112
	NM_001547
	NM_008332 ; NM_001355262
	NP_001538
	NP_032358 ; NP_001342191
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 18, 2024

Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene.^[5]^[6]^[7] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein.^[8] The IFIT2 gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one the many type 1 interferon-stimulated genes.^[8]^[9]^[10]

Clinical significance

IFIT2 may play a role in preventing tumor progression.^[11] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[12] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[12]

Related Research Articles

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Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include potentiation of Interferon gamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized proteins and negative regulation of the IFN-I response.

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.

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Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.

Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene.

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

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Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49), is a protein that in humans is encoded by the IFIT3 gene. It plays a part in the innate immune response to viruses in response to type I interferon signaling.

An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. Interferons bind to receptors on the surface of a cell, initiating protein signaling pathways within the cell. This interaction leads to the expression of a subset of genes involved in the innate immune system response. ISGs are commonly expressed in response to viral infection, but also during bacterial infection and in the presence of parasites. It's currently estimated that 10% of the human genome is regulated by interferons (IFNs). Interferon stimulated genes can act as an initial response to pathogen invasion, slowing down viral replication and increasing expression of immune signaling complexes. There are three known types of interferon. With approximately 450 genes highly expressed in response to interferon type I. Type I interferon consists of INF-α, INF-β, INF-ω and is expressed in response to viral infection. ISGs induced by type I interferon are associated with viral replication suppression and increase expression of immune signaling proteins. Type II interferon consists only of INF-γ and is associated with controlling intracellular pathogens and tumor suppressor genes. Type III interferon consists of INF-λ and is associated with viral immune response and is key in anti-fungal neutrophil response.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119922 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045932 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.
↑ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. Bibcode:1988FEBSL.231..164W. doi: 10.1016/0014-5793(88)80724-5 . PMID 3360121. S2CID 22937671.
↑ "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".
1 2 Mears HV, Sweeney TR (November 2018). "Better together: the role of IFIT protein-protein interactions in the antiviral response". The Journal of General Virology. 99 (11): 1463–1477. doi:10.1099/jgv.0.001149. PMID 30234477.
↑ Zhou X, Michal JJ, Zhang L, Ding B, Lunney JK, Liu B, Jiang Z (2013). "Interferon induced IFIT family genes in host antiviral defense". International Journal of Biological Sciences. 9 (2): 200–8. doi:10.7150/ijbs.5613. PMC 3584916 . PMID 23459883.
↑ Lang R, Li H, Luo X, Liu C, Zhang Y, Guo S, Xu J, Bao C, Dong W, Yu Y (2022). "Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases". Frontiers in Immunology. 13: 1008072. doi: 10.3389/fimmu.2022.1008072 . PMC 9618809 . PMID 36325336.
↑ Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi: 10.1158/1541-7786.MCR-08-0141 . PMID 18819931.
1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl: 11392/2066612 . PMID 25205602. S2CID 24986454.

Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.
Wathelet MG, Clauss IM, Content J, Huez GA (1988). "Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses". Eur. J. Biochem. 174 (2): 323–9. doi:10.1111/j.1432-1033.1988.tb14101.x. PMID 2454816.
Ulker N, Zhang X, Samuel CE (1988). "Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component". J. Biol. Chem. 262 (35): 16798–803. doi: 10.1016/S0021-9258(18)45454-3 . PMID 3119591.
Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE (1987). "Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8929–33. doi: 10.1073/pnas.83.23.8929 . PMC 387047 . PMID 3466167.
Zhu H, Cong JP, Shenk T (1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13985–90. doi: 10.1073/pnas.94.25.13985 . PMC 28419 . PMID 9391139.
Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, Filiukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. doi:10.1023/a:1023260415910. PMID 12708317. S2CID 34300356.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi: 10.1074/jbc.M605771200 . PMID 16973618.
Saha S, Sugumar P, Bhandari P, Rangarajan PN (2006). "Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein". J. Gen. Virol. 87 (Pt 11): 3285–9. doi: 10.1099/vir.0.82107-0 . PMID 17030862.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119922 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045932 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3175763-5] Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.

[pmid3360121-6] Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. Bibcode:1988FEBSL.231..164W. doi: 10.1016/0014-5793(88)80724-5 . PMID 3360121. S2CID 22937671.

[entrez-7] "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".

[pmid30234477-8] 1 2 Mears HV, Sweeney TR (November 2018). "Better together: the role of IFIT protein-protein interactions in the antiviral response". The Journal of General Virology. 99 (11): 1463–1477. doi:10.1099/jgv.0.001149. PMID 30234477.

[pmid23459883-9] Zhou X, Michal JJ, Zhang L, Ding B, Lunney JK, Liu B, Jiang Z (2013). "Interferon induced IFIT family genes in host antiviral defense". International Journal of Biological Sciences. 9 (2): 200–8. doi:10.7150/ijbs.5613. PMC 3584916 . PMID 23459883.

[pmid36325336-10] Lang R, Li H, Luo X, Liu C, Zhang Y, Guo S, Xu J, Bao C, Dong W, Yu Y (2022). "Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases". Frontiers in Immunology. 13: 1008072. doi: 10.3389/fimmu.2022.1008072 . PMC 9618809 . PMID 36325336.

[pmid18819931-11] Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi: 10.1158/1541-7786.MCR-08-0141 . PMID 18819931.

[Rotondo_2015-12] 1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl: 11392/2066612 . PMID 25205602. S2CID 24986454.

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IFIT2

Contents

Clinical significance

Related Research Articles

References

Further reading