IFT27

IFT27
Identifiers
Aliases	IFT27 , BBS19, RABL4, RAYL, intraflagellar transport 27, FAP156
External IDs	OMIM: 615870 MGI: 1914292 HomoloGene: 4998 GeneCards: IFT27
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,776,256 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,058,307 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; bronchial epithelial cell; ; anterior pituitary; ; caudate nucleus; ; nucleus accumbens; ; right lobe of thyroid gland; ; Right adrenal gland; ; amygdala; ; putamen; ; left lobe of thyroid gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; medial ganglionic eminence; ; facial motor nucleus; ; condyle; ; fossa; ; maxillary prominence; ; spermatocyte; ; medullary collecting duct; ; barrel cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; protein binding ; GTPase activity ;
Cellular component	cell projection ; motile cilium ; sperm principal piece ; sperm midpiece ; ciliary tip ; centrosome ; intraciliary transport particle B ; endosome ; Golgi apparatus ; cilium ; cytoplasm ; sperm flagellum ; membrane ; intracellular anatomical structure ;
Biological process	smoothened signaling pathway ; protein transport ; intracellular protein transport ; intraciliary transport ; cochlea development ; inner ear receptor cell stereocilium organization ; intraciliary transport involved in cilium assembly ; kidney development ; spermatogenesis ; Rab protein signal transduction ; cell differentiation ; signal transduction ; small GTPase mediated signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	11020
	67042
	ENSG00000100360
	ENSMUSG00000016637
	Q9BW83
	Q9D0P8
	NM_001177701 ; NM_001177702 ; NM_006860 ; NM_001363003
	NM_025931
	NP_001171172 ; NP_006851 ; NP_001349932
	NP_080207
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Intraflagellar transport 27 is a protein that in humans is encoded by the IFT27 gene. ^[5]

Function

This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].

Related Research Articles

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Intraflagellar transport protein 46 homolog is a protein that in humans is encoded by the IFT46 gene.

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene. Together with IFT74/72 it forms a core complex to build IFT particles which are required for cilium formation. Additionally, it interacts with basal body components as CEP170 which regulates the disassembly of the cilium.

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.

Intraflagellar transport protein 80 homolog (IFT80), also known as WD repeat-containing protein 56, is a protein that in humans is encoded by the IFT80 gene.

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Forkhead box B1 is a protein that in humans is encoded by the FOXB1 gene.

Solute carrier family 22 member 15 is a protein that in humans is encoded by the SLC22A15 gene.

Solute carrier family 17 member 9 is a protein that in humans is encoded by the SLC17A9 gene.

Solute carrier family 38 member 5 is a protein that in humans is encoded by the SLC38A5 gene.

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Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100360 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016637 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Intraflagellar transport 27" . Retrieved 2018-05-22.

IFT27

Contents

Function

Related Research Articles

References

Further reading