IHPK1

IP6K1
Identifiers
Aliases	IP6K1 , IHPK1, PiUS, inositol hexakisphosphate kinase 1
External IDs	OMIM: 606991 MGI: 1351633 HomoloGene: 56602 GeneCards: IP6K1
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 49,724,294 bp [1] End 49,786,542 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 107,879,700 bp [2] End 107,925,981 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle frontal gyrus frontal pole prefrontal cortex Brodmann area 10 stromal cell of endometrium cingulate gyrus Brodmann area 9 cerebellar vermis nucleus accumbens ganglionic eminence Top expressed in spermatid spermatocyte dorsomedial hypothalamic nucleus cerebellar cortex superior frontal gyrus habenula subiculum paraventricular nucleus of hypothalamus entorhinal cortex supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol hexakisphosphate 5-kinase activity transferase activity inositol hexakisphosphate 1-kinase activity nucleotide binding ATP binding inositol hexakisphosphate 3-kinase activity kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol 5-diphosphate pentakisphosphate 5-kinase activity inositol diphosphate tetrakisphosphate kinase activity inositol heptakisphosphate kinase activity protein binding inositol hexakisphosphate kinase activity Cellular component cytoplasm nucleus nucleoplasm fibrillar center cytosol Biological process phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process phosphorylation inositol phosphate biosynthetic process negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9807 27399 Ensembl ENSG00000176095 ENSMUSG00000032594 UniProt Q92551 Q6PD10 RefSeq (mRNA) NM_153273 NM_001006115 NM_001242829 NM_013785 NM_026266 RefSeq (protein) NP_001006115 NP_001229758 NP_695005 NP_038813 Location (UCSC) Chr 3: 49.72 – 49.79 Mb Chr 9: 107.88 – 107.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene. ^[5]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000176095 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032594 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IHPK1 inositol hexaphosphate kinase 1".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
• White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3". Somat. Cell Mol. Genet. 24 (1): 71–4. doi:10.1007/BF02677496. PMID   9776982. S2CID   22338269.
• Schell MJ, Letcher AJ, Brearley CA, et al. (1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Lett. 461 (3): 169–72. doi:10.1016/S0014-5793(99)01462-3. PMID   10567691. S2CID   6834292.
• Saiardi A, Erdjument-Bromage H, Snowman AM, et al. (2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr. Biol. 9 (22): 1323–6. doi: 10.1016/S0960-9822(00)80055-X . PMID   10574768. S2CID   15311443.
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis". J. Biol. Chem. 275 (32): 24686–92. doi: 10.1074/jbc.M002750200 . PMID   10827188.
• Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase". J. Biol. Chem. 276 (42): 39179–85. doi: 10.1074/jbc.M106842200 . PMID   11502751.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kamimura J, Wakui K, Kadowaki H, et al. (2004). "The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus". J. Hum. Genet. 49 (7): 360–5. doi: 10.1007/s10038-004-0158-z . PMID   15221640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

See also

• Inositol-hexakisphosphate kinase