Inositol-hexakisphosphate kinase

Inositol-hexakisphosphate kinase
Identifiers
EC no.	2.7.4.21
CAS no.	176898-37-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Inositol-hexakisphosphate kinase (EC 2.7.4.21, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

(1) ATP + 1D-myo-inositol hexakisphosphate(Phytic acid) ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

(2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)

Three mammalian isoforms are known to exist.

See also

• IHPK1
• IHPK2

References

1. Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (November 1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology. 9 (22): 1323–6. Bibcode:1999CBio....9.1323S. doi: 10.1016/S0960-9822(00)80055-X . PMID   10574768.
2. Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF (November 1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Letters. 461 (3): 169–72. Bibcode:1999FEBSL.461..169S. doi:10.1016/S0014-5793(99)01462-3. PMID   10567691.
3. Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, Mayr GW (October 1997). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". The Biochemical Journal. 327 ( Pt 2) (2): 553–60. doi:10.1042/bj3270553. PMC   1218829 . PMID   9359429.

External links

• Inositol-hexakisphosphate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)