IHPK2

IP6K2
Identifiers
Aliases	IP6K2 , IHPK2, PIUS, inositol hexakisphosphate kinase 2, InsP6K2
External IDs	OMIM: 606992 MGI: 1923750 HomoloGene: 56929 GeneCards: IP6K2
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 48,688,003 bp [1] End 48,740,353 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence tibial nerve skin of abdomen right uterine tube anterior pituitary right lobe of thyroid gland left lobe of thyroid gland rectum canal of the cervix minor salivary gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity inositol hexakisphosphate 5-kinase activity transferase activity inositol hexakisphosphate 1-kinase activity nucleotide binding protein binding ATP binding inositol hexakisphosphate 3-kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol 5-diphosphate pentakisphosphate 5-kinase activity inositol diphosphate tetrakisphosphate kinase activity inositol heptakisphosphate kinase activity inositol hexakisphosphate kinase activity flavonoid binding Cellular component nucleus nucleoplasm fibrillar center cell junction intermediate filament cytoskeleton Biological process phosphate ion transport phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process type I interferon signaling pathway negative regulation of cell growth phosphorylation positive regulation of apoptotic process inositol phosphate biosynthetic process cellular response to flavonoid lipid metabolism phosphatidylinositol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51447 76500 Ensembl ENSG00000068745 ENSMUSG00000032599 UniProt Q9UHH9 Q80V72 RefSeq (mRNA) NM_001005909 NM_001005910 NM_001005911 NM_001005912 NM_001005913 NM_001146178 NM_001146179 NM_001190316 NM_001190317 NM_016291 NM_029634 RefSeq (protein) NP_001005909 NP_001005910 NP_001005911 NP_001139650 NP_001139651 NP_001177245 NP_001177246 NP_057375 NP_083910 NP_001366529 NP_001366530 NP_001366531 NP_001366532 Location (UCSC) Chr 3: 48.69 – 48.74 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene. ^{[4] [5]}

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000068745 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (May 2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr Biol. 9 (22): 1323–6. doi: 10.1016/S0960-9822(00)80055-X . PMID   10574768. S2CID   15311443.
5. "Entrez Gene: IHPK2 inositol hexaphosphate kinase 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3". Somat. Cell Mol. Genet. 24 (1): 71–4. doi:10.1007/BF02677496. PMID   9776982. S2CID   22338269.
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis". J. Biol. Chem. 275 (32): 24686–92. doi: 10.1074/jbc.M002750200 . PMID   10827188.
• Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ (2001). "Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells". J. Biol. Chem. 276 (27): 24965–70. doi: 10.1074/jbc.M101161200 . PMC   2025680 . PMID   11337497.
• Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase". J. Biol. Chem. 276 (42): 39179–85. doi: 10.1074/jbc.M106842200 . PMID   11502751.
• Morrison BH, Bauer JA, Hu J, et al. (2002). "Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics". Oncogene. 21 (12): 1882–9. doi:10.1038/sj.onc.1205265. PMC   2043497 . PMID   11896621.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nagata E, Luo HR, Saiardi A, et al. (2005). "Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death". J. Biol. Chem. 280 (2): 1634–40. doi: 10.1074/jbc.M409416200 . PMID   15533939.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Morrison BH, Bauer JA, Lupica JA, et al. (2007). "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation". J. Biol. Chem. 282 (21): 15349–56. doi: 10.1074/jbc.M700156200 . PMC   2048714 . PMID   17379600.

See also

• Inositol-hexakisphosphate kinase