IL1RAPL2

IL1RAPL2
Identifiers
Aliases	IL1RAPL2 , IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1, interleukin 1 receptor accessory protein like 2
External IDs	OMIM: 300277; MGI: 1913106; HomoloGene: 9681; GeneCards: IL1RAPL2; OMA:IL1RAPL2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.3 Start 104,566,199 bp [1] End 105,767,829 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F1 Start 136,471,357 bp [2] End 137,747,695 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad prefrontal cortex right lobe of liver skin of hip Brodmann area 9 placenta urinary bladder gallbladder primary visual cortex Top expressed in multiform layer of neocortex internal granular layer Purkinje cell external pyramidal layer of neocortex embryo internal pyramidal layer of neocortex barrel cortex primary visual cortex median eminence superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-1, type II, blocking receptor activity interleukin-1 receptor activity Cellular component integral component of membrane membrane plasma membrane glutamatergic synapse Biological process central nervous system development signal transduction cytokine-mediated signaling pathway regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26280 60367 Ensembl ENSG00000189108 ENSMUSG00000059203 UniProt Q9NP60 Q9ERS6 RefSeq (mRNA) NM_017416 NM_030688 RefSeq (protein) NP_059112 NP_109613 Location (UCSC) Chr X: 104.57 – 105.77 Mb Chr X: 136.47 – 137.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the IL1RAPL2 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000189108 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059203 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID   10757639. S2CID   22262168.
6. "Entrez Gene: IL1RAPL2 interleukin 1 receptor accessory protein-like 2".

Further reading

• Grundtman C, Salomonsson S, Dorph C, et al. (2007). "Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies". Arthritis Rheum. 56 (2): 674–87. CiteSeerX   10.1.1.489.4969 . doi:10.1002/art.22388. PMID   17265504.
• Libra M, Mangano K, Anzaldi M, et al. (2006). "Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders". Oncol. Rep. 15 (5): 1305–8. doi: 10.3892/or.15.5.1305 . PMID   16596202.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ferrante MI, Ghiani M, Bulfone A, Franco B (2001). "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system". Gene. 275 (2): 217–21. doi:10.1016/S0378-1119(01)00659-X. PMID   11587848.
• Sana TR, Debets R, Timans JC, et al. (2001). "Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3". Genomics. 69 (2): 252–62. doi:10.1006/geno.2000.6328. PMID   11031108.
• Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi: 10.1074/jbc.M004077200 . PMID   10882729.
• Nagaoka H, Ozawa K, Matsuda F, et al. (1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16". Genomics. 22 (1): 189–97. doi:10.1006/geno.1994.1360. PMID   7959766.