INPP4B

INPP4B
Identifiers
Aliases	INPP4B , inositol polyphosphate-4-phosphatase type II B
External IDs	OMIM: 607494 MGI: 2158925 HomoloGene: 20832 GeneCards: INPP4B
Gene location (Human)
Chr.	Chromosome 4 (human)
End	142,847,432 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	82,854,543 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; superficial temporal artery; ; sural nerve; ; parietal pleura; ; visceral pleura; ; biceps brachii; ; right ventricle; ; germinal epithelium; ; secondary oocyte;
	Top expressed in
	soleus muscle; ; lymph node; ; intercostal muscle; ; myocardium of ventricle; ; thymus; ; blood; ; substantia nigra; ; spleen; ; thoracic diaphragm; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ; protein binding ; hydrolase activity ; inositol-3,4-bisphosphate 4-phosphatase activity ; inositol-1,3,4-trisphosphate 4-phosphatase activity ; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity ;
Cellular component	cytosol ; cytoplasm ;
Biological process	phosphatidylinositol biosynthetic process ; phosphatidylinositol-3-phosphate biosynthetic process ; inositol phosphate metabolic process ; signal transduction ; dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	8821
	234515
	ENSG00000109452
	ENSMUSG00000037940
	O15327
	Q6P1Y8
	NM_001101669 ; NM_003866 ; NM_001331040
	NM_001024617 ; NM_001297591 ; NM_001297593 ; NM_001297596
	NP_001095139 ; NP_001317969 ; NP_003857
	NP_001019788 ; NP_001284520 ; NP_001284522 ; NP_001284525
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.^[5]

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines.^[6] There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.^[5]

Related Research Articles

<i>PTEN</i> (gene) Tumor suppressor gene

Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.

<span class="mw-page-title-main">Phosphatidylinositol 3,4-bisphosphate</span>

Phosphatidylinositol (3,4)-bisphosphate is a minor phospholipid component of cell membranes, yet an important second messenger. The generation of PtdIns(3,4)P₂ at the plasma membrane activates a number of important cell signaling pathways.

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.

The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction

The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction

The enzyme phosphatidylinositol-3-phosphatase (EC 3.1.3.64) catalyzes the reaction

Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1(SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene. INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene.

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.

72 kDa inositol polyphosphate 5-phosphatase, also known as phosphatidylinositol-4,5-bisphosphate 5-phosphatase or Pharbin, is an enzyme that in humans is encoded by the INPP5E gene.

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P₂ 4-Ptase, type II PtdIns-4,5-P₂ 4-Ptase, IpgD, PtdIns-4,5-P₂ 4-phosphatase type I, PtdIns-4,5-P₂ 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. This enzyme catalyses the following chemical reaction

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase, that has two isoforms: SHIP1 and SHIP2 (INPPL1).

Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109452 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037940 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa" . Retrieved 2012-07-24.
↑ Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU (October 2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications. 440 (2): 277–82. doi:10.1016/j.bbrc.2013.09.077. PMC 4578723 . PMID 24070612.

Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU (October 2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications. 440 (2): 277–82. doi:10.1016/j.bbrc.2013.09.077. PMC 4578723 . PMID 24070612.
Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC (August 2009). "Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling". Cancer Cell. 16 (2): 115–25. doi:10.1016/j.ccr.2009.06.006. PMC 2957372 . PMID 19647222.
Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, Agoulnik IU (January 2011). "Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer". Cancer Research. 71 (2): 572–82. doi:10.1158/0008-5472.CAN-10-2314. PMC 3077543 . PMID 21224358.
Norris FA, Atkins RC, Majerus PW (September 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". The Journal of Biological Chemistry. 272 (38): 23859–64. doi: 10.1074/jbc.272.38.23859 . PMID 9295334.
Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA (March 1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3640–5. Bibcode:1999PNAS...96.3640M. doi: 10.1073/pnas.96.7.3640 . PMC 22347 . PMID 10097090.
Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S (November 2010). "Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation". BMC Evolutionary Biology. 10 (1): 351. Bibcode:2010BMCEE..10..351A. doi: 10.1186/1471-2148-10-351 . PMC 2996405 . PMID 21070662.
Norris FA, Auethavekiat V, Majerus PW (July 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". The Journal of Biological Chemistry. 270 (27): 16128–33. doi: 10.1074/jbc.270.27.16128 . PMID 7608176.
Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR (December 2007). "Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations". Diabetes. 56 (12): 3053–62. doi: 10.2337/db07-0457 . PMID 17846126.
Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA (December 2010). "Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers". Proceedings of the National Academy of Sciences of the United States of America. 107 (51): 22231–6. Bibcode:2010PNAS..10722231F. doi: 10.1073/pnas.1015245107 . PMC 3009830 . PMID 21127264.
Zhang X, Majerus PW (April 1998). "Phosphatidylinositol signalling reactions". Seminars in Cell & Developmental Biology. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM (April 2011). "INPP4B: the new kid on the PI3K block". Oncotarget. 2 (4): 321–8. doi:10.18632/oncotarget.260. PMC 3248162 . PMID 21487159.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000109452 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037940 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa" . Retrieved 2012-07-24.

[6] Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU (October 2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications. 440 (2): 277–82. doi:10.1016/j.bbrc.2013.09.077. PMC 4578723 . PMID 24070612.

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INPP4B

Related Research Articles

References

Further reading