INT-777

Last updated

INT-777
INT-777 structure.png
Identifiers
  • (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C27H46O5
Molar mass 450.660 g·mol−1
3D model (JSmol)
  • CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3C[C@@H]([C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)C[C@H](C)C(=O)O)C)O)C)O
  • InChI=1S/C27H46O5/c1-6-17-20-12-16(28)9-10-26(20,4)21-13-22(29)27(5)18(14(2)11-15(3)25(31)32)7-8-19(27)23(21)24(17)30/h14-24,28-30H,6-13H2,1-5H3,(H,31,32)/t14-,15+,16-,17-,18-,19+,20+,21+,22+,23+,24-,26+,27-/m1/s1
  • Key:NPBCMXATLRCCLF-IRRLEISYSA-N

INT-777 is an experimental drug which acts as a potent and selective agonist for the G protein-coupled bile acid receptor (GPBAR1/TGR5). It has antiinflammatory effects and has been researched for various conditions including diabetes and pulmonary arterial hypertension. [1] [2] [3] [4]

References

  1. ↑ Holst JJ, McGill MA (2012). "Potential New Approaches to Modifying Intestinal GLP-1 Secretion in Patients with Type 2 Diabetes Mellitus". Clinical Drug Investigation. 32 (1): 1–14. doi:10.2165/11595370-000000000-00000. PMID   27933595.
  2. ↑ Comeglio P, Morelli A, Adorini L, Maggi M, Vignozzi L (November 2017). "Beneficial effects of bile acid receptor agonists in pulmonary disease models". Expert Opinion on Investigational Drugs. 26 (11): 1215–1228. doi:10.1080/13543784.2017.1385760. PMID   28949776.
  3. ↑ Qi Y, Duan G, Wei D, Zhao C, Ma Y (August 2022). "The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?". Molecules. 27 (16). Basel, Switzerland: 5292. doi: 10.3390/molecules27165292 . PMC   9416356 . PMID   36014536.
  4. ↑ Romero-Ramírez L, Mey J (August 2024). "Emerging Roles of Bile Acids and TGR5 in the Central Nervous System: Molecular Functions and Therapeutic Implications". International Journal of Molecular Sciences. 25 (17): 9279. doi: 10.3390/ijms25179279 . PMC   11395147 . PMID   39273226.
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