INTS11

INTS11
Identifiers
Aliases	INTS11 , CPSF73L, INT11, RC-68, RC68, CPSF3L, cleavage and polyadenylation specific factor 3-like, integrator complex subunit 11
External IDs	OMIM: 611354; MGI: 1919207; HomoloGene: 9894; GeneCards: INTS11; OMA:INTS11 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.33 Start 1,311,585 bp [1] End 1,324,687 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 E2|4 87.66 cM Start 155,954,003 bp [2] End 155,973,560 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right uterine tube body of uterus right ovary left ovary canal of the cervix muscle layer of sigmoid colon pituitary gland left uterine tube fundus Top expressed in primitive streak granulocyte ventricular zone embryo morula epiblast medial ganglionic eminence spermatocyte embryo lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity protein binding Cellular component blood microparticle integrator complex nucleoplasm cytosol nucleus cytoplasm Biological process snRNA processing snRNA transcription by RNA polymerase II snRNA 3'-end processing regulation of RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54973 71957 Ensembl ENSG00000127054 ENSMUSG00000029034 UniProt Q5TA45 Q9CWS4 RefSeq (mRNA) NM_001256456 NM_001256460 NM_001256462 NM_001256463 NM_017871 NM_032179 NM_028020 RefSeq (protein) NP_001243385 NP_001243389 NP_001243391 NP_001243392 NP_060341 NP_082296 Location (UCSC) Chr 1: 1.31 – 1.32 Mb Chr 4: 155.95 – 155.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 11 is a protein that in humans is encoded by the CPSF3L gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000127054 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029034 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dominski Z, Yang XC, Purdy M, Wagner EJ, Marzluff WF (Feb 2005). "A CPSF-73 Homologue Is Required for Cell Cycle Progression but Not Cell Growth and Interacts with a Protein Having Features of CPSF-100". Mol Cell Biol. 25 (4): 1489–500. doi:10.1128/MCB.25.4.1489-1500.2005. PMC   548002 . PMID   15684398.
6. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID   16239144. S2CID   18069461.
7. "Entrez Gene: CPSF3L cleavage and polyadenylation specific factor 3-like".

External links

• Human CPSF3L genome location and CPSF3L gene details page in the UCSC Genome Browser .

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.