INTS3

INTS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OWT, 4OWW, 4OWX
Identifiers
Aliases	INTS3 , C1orf193, C1orf60, INT3, SOSS-A, SOSSA, integrator complex subunit 3
External IDs	OMIM: 611347; MGI: 2140050; HomoloGene: 11309; GeneCards: INTS3; OMA:INTS3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,728,050 bp [1] End 153,774,808 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 90,298,695 bp [2] End 90,340,929 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube pituitary gland right ovary left ovary anterior pituitary canal of the cervix body of uterus right adrenal gland right adrenal cortex ascending aorta Top expressed in tail of embryo Paneth cell Ileal epithelium genital tubercle secondary oocyte yolk sac zygote habenula epiblast primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integrator complex SOSS complex nucleus nucleoplasm nucleolus cytoplasm Biological process response to ionizing radiation DNA repair snRNA processing cellular response to DNA damage stimulus mitotic cell cycle checkpoint signaling snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65123 229543 Ensembl ENSG00000143624 ENSG00000262826 ENSMUSG00000027933 UniProt Q68E01 Q7TPD0 RefSeq (mRNA) NM_023015 NM_001324475 NM_145540 NM_178876 RefSeq (protein) NP_001311404 NP_075391 NP_663515 NP_849207 Location (UCSC) Chr 1: 153.73 – 153.77 Mb Chr 3: 90.3 – 90.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 3 is a protein that in humans is encoded by the INTS3 gene. ^{[5] [6]}

References

1. ENSG00000262826 GRCh38: Ensembl release 89: ENSG00000143624, ENSG00000262826 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027933 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID   16239144. S2CID   18069461.
6. "Entrez Gene: INTS3 integrator complex subunit 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC   311073 . PMID   11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.