INTS3

INTS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OWT, 4OWW, 4OWX
Identifiers
Aliases	INTS3 , C1orf193, C1orf60, INT3, SOSS-A, SOSSA, integrator complex subunit 3
External IDs	OMIM: 611347 MGI: 2140050 HomoloGene: 11309 GeneCards: INTS3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,774,808 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,340,929 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; canal of the cervix; ; Right adrenal gland; ; ascending aorta; ; myometrium; ; right lobe of thyroid gland; ; fundus; ; tibial nerve;
	Top expressed in
	Paneth cell; ; secondary oocyte; ; yolk sac; ; habenula; ; primitive streak; ; medullary collecting duct; ; mirror; ; renal corpuscle; ; substantia nigra; ; motor neuron;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	integrator complex ; SOSS complex ; nucleus ; nucleoplasm ; nucleolus ; cytoplasm ;
Biological process	response to ionizing radiation ; DNA repair ; snRNA processing ; cellular response to DNA damage stimulus ; mitotic cell cycle checkpoint signaling ; snRNA transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	65123
	229543
	ENSG00000143624 ; ENSG00000262826
	ENSMUSG00000027933
	Q68E01
	Q7TPD0
	NM_023015 ; NM_001324475
	NM_145540 ; NM_178876
	NP_001311404 ; NP_075391
	NP_663515 ; NP_849207
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Integrator complex subunit 3 is a protein that in humans is encoded by the INTS3 gene.^[5]^[6]

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References

1 2 3 ENSG00000262826 GRCh38: Ensembl release 89: ENSG00000143624, ENSG00000262826 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027933 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID 16239144. S2CID 18069461.
↑ "Entrez Gene: INTS3 integrator complex subunit 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073 . PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000262826 GRCh38: Ensembl release 89: ENSG00000143624, ENSG00000262826 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027933 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16239144-5] Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID 16239144. S2CID 18069461.

[entrez-6] "Entrez Gene: INTS3 integrator complex subunit 3".

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[4]

[5]

[6]

INTS3

Related Research Articles

References

Further reading