INTS6

INTS6
Identifiers
Aliases	INTS6 , DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDs	OMIM: 604331; MGI: 1202397; HomoloGene: 8121; GeneCards: INTS6; OMA:INTS6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 51,354,077 bp [1] End 51,454,264 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D1 Start 62,913,779 bp [2] End 62,998,618 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon optic nerve right testis left testis epithelium of colon tonsil body of pancreas ventricular zone gingival epithelium Top expressed in spermatocyte spermatid tail of embryo seminiferous tubule Gonadal ridge lacrimal gland genital tubercle human fetus gastrula cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity Cellular component integrator complex actin cytoskeleton nucleoplasm nucleus Biological process snRNA processing snRNA transcription by RNA polymerase II signal transduction snRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26512 18130 Ensembl ENSG00000102786 ENSMUSG00000035161 UniProt Q9UL03 Q6PCM2 RefSeq (mRNA) NM_001039937 NM_001039938 NM_001306091 NM_012141 NM_008715 RefSeq (protein) NP_001035026 NP_001035027 NP_001293020 NP_036273 NP_032741 Location (UCSC) Chr 13: 51.35 – 51.45 Mb Chr 14: 62.91 – 63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene. ^{[5] [6] [7]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000102786 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035161 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi: 10.1038/sj.onc.1202806 . PMID   10467397.
6. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID   16239144.
7. "Entrez Gene: INTS6 integrator complex subunit 6".

Further reading

• Buchsbaum S, Morris C, Bochard V, Jalinot P (2007). "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle". Oncogene. 26 (35): 5132–44. doi:10.1038/sj.onc.1210314. PMID   17310990. S2CID   2886919.
• Hernández M, Papadopoulos N, Almeida TA (2006). "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions". Cancer Genet. Cytogenet. 163 (1): 91–2. doi:10.1016/j.cancergencyto.2005.04.014. PMID   16271964.
• Röpke A, Buhtz P, Böhm M, et al. (2005). "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer". Oncogene. 24 (44): 6667–75. doi:10.1038/sj.onc.1208824. PMID   16007164. S2CID   12129480.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wieland I, Sell C, Weidle UH, Wieacker P (2005). "Ectopic expression of DICE1 suppresses tumor cell growth". Oncol. Rep. 12 (2): 207–11. doi:10.3892/or.12.2.207. PMID   15254679.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Li WJ, Hu N, Su H, et al. (2003). "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma". Oncogene. 22 (2): 314–8. doi:10.1038/sj.onc.1206098. PMID   12527901. S2CID   10839440.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wieland I, Röpke A, Stumm M, et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells". Oncol. Res. 12 (11–12): 491–500. doi: 10.3727/096504001108747503 . PMID   11939413.
• Camargo AA, Nunes DN, Samaia HB, et al. (2002). "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12". Braz. J. Med. Biol. Res. 34 (10): 1237–45. doi: 10.1590/s0100-879x2001001000002 . PMID   11593297.