INTS8

INTS8
Identifiers
Aliases	INTS8 , C8orf52, INT8, integrator complex subunit 8, NEDCHS
External IDs	OMIM: 611351 MGI: 1919906 HomoloGene: 9888 GeneCards: INTS8
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q22.1 Start 94,813,311 bp [1] End 94,881,746 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A1 Start 11,199,158 bp [2] End 11,254,258 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon body of pancreas canal of the cervix ganglionic eminence rectum right lobe of thyroid gland bone marrow cells right uterine tube monocyte Top expressed in otic placode somite saccule medial ganglionic eminence superior cervical ganglion hand maxillary prominence foot atrioventricular valve secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integrator complex nucleus nucleoplasm Biological process snRNA processing snRNA transcription by RNA polymerase II snRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55656 72656 Ensembl ENSG00000164941 ENSMUSG00000040738 UniProt Q75QN2 Q80V86 RefSeq (mRNA) NM_017864 NM_001159595 NM_178112 RefSeq (protein) NP_060334 NP_001153067 NP_835213 Location (UCSC) Chr 8: 94.81 – 94.88 Mb Chr 4: 11.2 – 11.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 8 is a protein that in humans is encoded by the INTS8 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000164941 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040738 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID   16239144. S2CID   18069461.
6. "Entrez Gene: INTS8 integrator complex subunit 8".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.