IPO8

IPO8
Identifiers
Aliases	IPO8 , RANBP8, importin 8, VISS
External IDs	OMIM: 605600 MGI: 2444611 HomoloGene: 48430 GeneCards: IPO8
Gene location (Human)
Chr.	Chromosome 12 (human)
End	30,695,869 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	148,831,467 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; internal globus pallidus; ; Achilles tendon; ; superficial temporal artery; ; seminal vesicula; ; jejunal mucosa; ; rectum; ; sural nerve; ; endothelial cell; ; renal medulla;
	Top expressed in
	secondary oocyte; ; cumulus cell; ; medial vestibular nucleus; ; pituitary gland; ; superior cervical ganglion; ; left lobe of liver; ; dorsomedial hypothalamic nucleus; ; parotid gland; ; ureter; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; nucleus ; nucleoplasm ; nuclear envelope ; cytosol ;
Biological process	protein transport ; intracellular protein transport ; signal transduction ; regulation of gene silencing by miRNA ; protein import into nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	10526
	320727
	ENSG00000133704
	ENSMUSG00000040029
	O15397
	Q7TMY7
	NM_001190995 ; NM_006390
	NM_001081113
	NP_001177924 ; NP_006381
	NP_001074582
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Importin 8 is a protein that in humans is encoded by the IPO8 gene.^[5]

Function

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

Related Research Articles

A nuclear localization signalorsequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport. Typically, this signal consists of one or more short sequences of positively charged lysines or arginines exposed on the protein surface. Different nuclear localized proteins may share the same NLS. An NLS has the opposite function of a nuclear export signal (NES), which targets proteins out of the nucleus.

Importin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. It does so by binding to specific recognition sequences, called nuclear localization sequences (NLS).

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

Nuclear transport refers to the mechanisms by which molecules move across the nuclear membrane of a cell. The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complexes (NPCs). Although small molecules can enter the nucleus without regulation, macromolecules such as RNA and proteins require association with transport factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit.

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene.

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.

<span class="mw-page-title-main">IPO5</span> Protein-coding gene in the species Homo sapiens

Importin-5 is a protein that in humans is encoded by the IPO5 gene. The protein encoded by this gene is a member of the importin beta family. Structurally, the protein adopts the shape of a right hand solenoid and is composed of 24 HEAT repeats.

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.

Transportin-1 is a protein that in humans is encoded by the TNPO1 gene.

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.

Importin-7 is a protein that in humans is encoded by the IPO7 gene.

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.

Exportin-T is a protein that in humans is encoded by the XPOT gene.

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.

Importin-13 is a protein encoded by the IPO13 gene in humans. Importin-13 is a member of the importin-β family of nuclear transport receptors (NTRs) and was first identified as a transport receptor in 2000. According to PSI-blast based secondary structure PREDiction (PSIPRED), importin-13 contains 38 α-helices. Importin-13 accommodates a range of cargoes due to its flexible superhelical structure and a cargo binding and release system that is distinct from other importin-like transport receptors. IPO13 is broadly expressed in a variety of tissues in the human body, including the heart, cornea, fetal lung, brain, endometrial carcinoma, and testes.

Importin alpha, or karyopherin alpha refers to a class of adaptor proteins that are involved in the import of proteins into the cell nucleus. They are a sub-family of karyopherin proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133704 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040029 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Importin 8".

Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (July 1997). "A novel class of RanGTP binding proteins". The Journal of Cell Biology. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951 . PMID 9214382.
Nozawa RS, Nagao K, Masuda HT, Iwasaki O, Hirota T, Nozaki N, Kimura H, Obuse C (July 2010). "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation". Nature Cell Biology. 12 (7): 719–27. doi:10.1038/ncb2075. PMID 20562864. S2CID 7389788.
Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM (September 2007). "Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study". BMC Medical Genetics. 8 (Suppl 1): S13. doi: 10.1186/1471-2350-8-S1-S13 . PMC 1995604 . PMID 17903295.
Nguewa PA, Agorreta J, Blanco D, Lozano MD, Gomez-Roman J, Sanchez BA, Valles I, Pajares MJ, Pio R, Rodriguez MJ, Montuenga LM, Calvo A (November 2008). "Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens". BMC Molecular Biology. 9: 103. doi: 10.1186/1471-2199-9-103 . PMC 2612021 . PMID 19014639.
Dean KA, von Ahsen O, Görlich D, Fried HM (October 2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". Journal of Cell Science. 114 (Pt 19): 3479–85. doi:10.1242/jcs.114.19.3479. hdl: 11858/00-001M-0000-0015-3D81-6 . PMID 11682607.
Weinmann L, Höck J, Ivacevic T, Ohrt T, Mütze J, Schwille P, Kremmer E, Benes V, Urlaub H, Meister G (February 2009). "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs". Cell. 136 (3): 496–507. doi:10.1016/j.cell.2008.12.023. hdl: 11858/00-001M-0000-0012-D8E1-E . PMID 19167051. S2CID 15876600.
Yao X, Chen X, Cottonham C, Xu L (August 2008). "Preferential utilization of Imp7/8 in nuclear import of Smads". The Journal of Biological Chemistry. 283 (33): 22867–74. doi: 10.1074/jbc.M801320200 . PMC 2504884 . PMID 18519565.
Zuo S, Xue Y, Tang S, Yao J, Du R, Yang P, Chen X (July 2010). "14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity". Journal of Proteome Research. 9 (7): 3465–78. doi:10.1021/pr9011377. PMID 20462248.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133704 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040029 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Importin 8".

[1]

[2]

[3]

[4]

[5]

IPO8

Contents

Function

Related Research Articles

References

Further reading