IQGAP2

IQGAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IEZ, 4EZA
Identifiers
Aliases	IQGAP2 , IQ motif containing GTPase activating protein 2
External IDs	OMIM: 605401 MGI: 2449975 HomoloGene: 101543 GeneCards: IQGAP2
Gene location (Human)
Chr.	Chromosome 5 (human) [1]
End	76,708,132 bp [1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse) [2]
End	95,892,483 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• Rac GTPase binding ; • Arp2/3 complex binding ; • GTPase inhibitor activity ; • actin filament binding ; • Rho GTPase binding ; • actin binding ; • phosphatidylinositol-3,4,5-trisphosphate binding ; • calmodulin binding ;
Cellular component	• cytoplasm ; • filamentous actin ; • cytosol ; • filopodium ; • microvilli ; • cell surface ; • actin cytoskeleton ; • microtubule ; • extracellular exosome ; • lamellipodium ; • cell membrane ; • secretory granule membrane ;
Biological process	• thrombin-activated receptor signaling pathway ; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity ; • Arp2/3 complex-mediated actin nucleation ; • signal transduction ; • GO:0034259 negative regulation of GTPase activity ; • neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	10788
	544963
	ENSG00000145703
	ENSMUSG00000021676
	Q13576
	Q3UQ44
	NM_001285460 ; NM_001285461 ; NM_001285462 ; NM_006633
	NM_027711
	NP_001272389 ; NP_001272390 ; NP_001272391 ; NP_006624
	NP_081987
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2020

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.^[5]^[6]

Function

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.^[6]

Interactions

IQGAP2 has been shown to interact with CDC42 ^[5] and RAC1.^[5]

Related Research Articles

Small GTPases, also known as small G-proteins, are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and hydrolyze a guanosine triphosphate (GTP) to form guanosine diphosphate (GDP). The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases.

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

CDC42 Protein-coding gene in the species Homo sapiens

Cell division control protein 42 homolog, also known as Cdc42, is a protein involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.

Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells. It is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which appear to carry out different functions.

Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 and DIAPH1 are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.

RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.

Rac2 is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RAC2.

RhoC is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOC.

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

GTP-binding protein RAD is a protein that in humans is encoded by the RRAD gene.

Rnd2 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145703 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021676 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. doi:10.1128/mcb.16.9.4869. PMC 231489 . PMID 8756646.
1 2 "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2".

McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. doi: 10.1074/jbc.271.36.21732 . PMID 8702968.
Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine. 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (2002). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi: 10.1074/jbc.M203816200 . PMID 12376551.
Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood. 101 (8): 3021–8. doi: 10.1182/blood-2002-09-2807 . PMID 12515716.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376-87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
Wang H, Huo R, Xu M, Lu L, Xu Z, Li J, Zhou Z, Sha J (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5–6): 319–25. doi:10.1080/10425170400009012. PMID 15621655. S2CID 22014226.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145703 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021676 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8756646-5] 1 2 3 Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. doi:10.1128/mcb.16.9.4869. PMC 231489 . PMID 8756646.

[entrez-6] 1 2 "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2".

IQGAP2

Contents

Function

Interactions

Related Research Articles

References

Further reading