IRF2BP2

IRF2BP2
Identifiers
Aliases	IRF2BP2 , interferon regulatory factor 2 binding protein 2, CVID14
External IDs	OMIM: 615332 MGI: 2443921 HomoloGene: 34290 GeneCards: IRF2BP2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	234,610,178 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	127,320,725 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; trachea; ; pancreatic epithelial cell; ; superior surface of tongue; ; pylorus; ; trigeminal ganglion; ; caput epididymis; ; nipple; ; pericardium; ; cancellous bone;
	Top expressed in
	aortic valve; ; ascending aorta; ; molar; ; hand; ; left lung lobe; ; left colon; ; body of femur; ; foot; ; right lung lobe; ; lymph node;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; DNA-binding transcription activator activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; nucleus ; nucleoplasm ;
Biological process	transcription, DNA-templated ; regulation of transcription, DNA-templated ; immature B cell differentiation ; negative regulation of transcription by RNA polymerase II ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	359948
	270110
	ENSG00000168264
	ENSMUSG00000051495
	Q7Z5L9
	E9Q1P8
	NM_182972 ; NM_001077397
	NM_001164598
	NP_001070865 ; NP_892017
	NP_001158070
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 15, 2023

Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene. ^[5]

Function

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Related Research Articles

Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by the IRF6 gene.

Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons. Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. Some viruses have evolved defense mechanisms that regulate and interfere with IRF functions to escape the host immune system. For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. The Kaposi sarcoma herpesvirus, KSHV, is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity. In addition, the expression of IRF genes is under epigenetic regulation by promoter DNA methylation.

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.

Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.

Interferon gamma receptor 1 (IFNGR1) also known as CD119, is a protein that in humans is encoded by the IFNGR1 gene.

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

ATP-binding cassette sub-family G member 5 is a protein that in humans is encoded by the ABCG5 gene.

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.

Transcription factor AP-2 alpha, also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene.

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene.

Vestigial like family member 4 is a protein that in humans is encoded by the VGLL4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168264 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051495 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Interferon regulatory factor 2 binding protein 2" . Retrieved 2017-01-06.

Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". Nucleic Acids Res. 31 (12): 3016–26. doi:10.1093/nar/gkg431. PMC 162335 . PMID 12799427.
Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". Cancer Res. 69 (4): 1375–82. doi:10.1158/0008-5472.CAN-08-2896. PMC 4264605 . PMID 19190336.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". Mol. Cell. Biol. 31 (14): 2889–901. doi:10.1128/MCB.00974-10. PMC 3133407 . PMID 21576369.
Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". PLOS ONE. 6 (8): e24100. Bibcode:2011PLoSO...624100T. doi: 10.1371/journal.pone.0024100 . PMC 3162591 . PMID 21887377.
Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLOS ONE. 7 (11): e49705. Bibcode:2012PLoSO...749705N. doi: 10.1371/journal.pone.0049705 . PMC 3504151 . PMID 23185413.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168264 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051495 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Interferon regulatory factor 2 binding protein 2" . Retrieved 2017-01-06.

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IRF2BP2

Contents

Function

Related Research Articles

References

Further reading