ISCA1

ISCA1
Identifiers
Aliases	ISCA1 , HBLD2, ISA1, hIscA, iron-sulfur cluster assembly 1, MMDS5
External IDs	OMIM: 611006; MGI: 1916296; HomoloGene: 87862; GeneCards: ISCA1; OMA:ISCA1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q21.33 Start 86,264,546 bp [1] End 86,283,102 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 B2 Start 59,903,223 bp [2] End 59,917,624 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell biceps brachii Skeletal muscle tissue of biceps brachii right ventricle trabecular bone kidney tubule Epithelium of choroid plexus pons myocardium Brodmann area 23 Top expressed in bone marrow brown adipose tissue tibialis anterior muscle soleus muscle quadriceps femoris muscle masseter muscle extraocular muscle myocardium of ventricle muscle of thigh cardiac muscles More reference expression data BioGPS n/a
Gene ontology Molecular function iron-sulfur cluster binding ferrous iron binding structural molecule activity metal ion binding 2 iron, 2 sulfur cluster binding Cellular component mitochondrion mitochondrial matrix Biological process iron-sulfur cluster assembly protein maturation by iron-sulfur cluster transfer small molecule metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81689 69046 Ensembl ENSG00000135070 ENSMUSG00000044792 UniProt Q9BUE6 Q9D924 RefSeq (mRNA) NM_030940 NM_026921 RefSeq (protein) NP_112202 NP_081197 Location (UCSC) Chr 9: 86.26 – 86.28 Mb Chr 13: 59.9 – 59.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Iron-sulfur cluster assembly 1 homolog, mitochondrial is an evolutionarily highly conserved protein for the biogenesis of iron-sulfur cluster across species. ^[5] In humans it is encoded by the ISCA1 gene. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000135070 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044792 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Beilschmidt LK, Puccio HM (May 2014). "Mammalian Fe-S cluster biogenesis and its implication in disease". Biochimie. 100: 48–60. doi:10.1016/j.biochi.2014.01.009. PMID   24440636.
6. Cózar-Castellano I, del Valle Machargo M, Trujillo E, Arteaga MF, González T, Martín-Vasallo P, Avila J (Aug 2004). "hIscA: a protein implicated in the biogenesis of iron-sulfur clusters". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1700 (2): 179–88. doi:10.1016/j.bbapap.2004.05.004. PMID   15262227.
7. "Entrez Gene: ISCA1 iron-sulfur cluster assembly 1 homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.