ITM2C

ITM2C
Identifiers
Aliases	ITM2C , BRI3, BRICD2C, E25, E25C, ITM3, integral membrane protein 2C
External IDs	OMIM: 609554 MGI: 1927594 HomoloGene: 11186 GeneCards: ITM2C
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 230,864,639 bp [1] End 230,879,248 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C5 Start 85,822,002 bp [2] End 85,836,396 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus amygdala external globus pallidus rectum prefrontal cortex hypothalamus putamen Brodmann area 9 pituitary gland Top expressed in olfactory tubercle nucleus accumbens supraoptic nucleus entorhinal cortex arcuate nucleus median eminence paraventricular nucleus of hypothalamus ventromedial nucleus habenula suprachiasmatic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amyloid-beta binding protein binding ATP binding Cellular component perinuclear region of cytoplasm integral component of membrane lysosomal membrane extracellular exosome membrane lysosome plasma membrane Golgi apparatus Biological process positive regulation of extrinsic apoptotic signaling pathway negative regulation of neuron projection development neuron differentiation negative regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81618 64294 Ensembl ENSG00000135916 ENSMUSG00000026223 UniProt Q9NQX7 Q91VK4 RefSeq (mRNA) NM_030926 NM_001012514 NM_001012516 NM_001287240 NM_001287241 NM_022417 RefSeq (protein) NP_001012532 NP_001012534 NP_001274169 NP_001274170 NP_112188 NP_071862 Location (UCSC) Chr 2: 230.86 – 230.88 Mb Chr 1: 85.82 – 85.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000135916 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026223 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
6. "Entrez Gene: ITM2C integral membrane protein 2C".

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID   7757816.
• Liew CC, Hwang DM, Fung YW, et al. (1994). "A catalogue of genes in the cardiovascular system as identified by expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10645–9. Bibcode:1994PNAS...9110645L. doi: 10.1073/pnas.91.22.10645 . PMC   45078 . PMID   7938007.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Deleersnijder W, Hong G, Cortvrindt R, et al. (1996). "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins". J. Biol. Chem. 271 (32): 19475–82. doi: 10.1074/jbc.271.32.19475 . PMID   8702637.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Vidal R, Calero M, Révész T, et al. (2001). "Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family". Gene. 266 (1–2): 95–102. doi:10.1016/S0378-1119(01)00374-2. PMID   11290423.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wu H, Liu G, Li C, Zhao S (2004). "bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death". Biochem. Biophys. Res. Commun. 311 (2): 518–24. doi:10.1016/j.bbrc.2003.10.038. PMID   14592447.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". J. Neurochem. 92 (1): 93–102. doi: 10.1111/j.1471-4159.2004.02840.x . PMID   15606899. S2CID   36799858.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.