ITPK1

ITPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q7D, 2ODT, 2QB5
Identifiers
Aliases	ITPK1 , ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDs	OMIM: 601838; MGI: 2446159; HomoloGene: 8588; GeneCards: ITPK1; OMA:ITPK1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.12 Start 92,936,914 bp [1] End 93,116,320 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 E Start 102,534,841 bp [2] End 102,671,189 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right frontal lobe anterior cingulate cortex prefrontal cortex amygdala nucleus accumbens sural nerve Brodmann area 9 right coronary artery caudate nucleus Top expressed in gastrula choroid plexus of fourth ventricle decidua crypt of lieberkuhn of small intestine intestinal villus ileum duodenum jejunum epithelium of small intestine CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding isomerase activity metal ion binding kinase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity catalytic activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity inositol-3,4,6-trisphosphate 1-kinase activity ATP binding hydrolase activity magnesium ion binding inositol-1,3,4-trisphosphate 6-kinase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity inositol-1,3,4-trisphosphate 5-kinase activity inositol tetrakisphosphate 1-kinase activity inositol tetrakisphosphate 6-kinase activity Cellular component cytosol intracellular anatomical structure apical plasma membrane cytoplasm Biological process phosphorylation blood coagulation inositol phosphate metabolic process inositol trisphosphate metabolic process neural tube development signal transduction dephosphorylation necroptosis inositol phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3705 217837 Ensembl ENSG00000100605 ENSG00000274958 ENSMUSG00000057963 UniProt Q13572 Q8BYN3 RefSeq (mRNA) NM_014216 NM_001142593 NM_001142594 NM_001363707 NM_172584 RefSeq (protein) NP_001136065 NP_001136066 NP_055031 NP_001350636 NP_766172 Location (UCSC) Chr 14: 92.94 – 93.12 Mb Chr 12: 102.53 – 102.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene. ^{[5] [6] [7]}

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis. ^{[8] [9]}

References

1. ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057963 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi: 10.1074/jbc.271.20.11904 . PMID   8662638.
6. Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC   1221393 . PMID   11042108.
7. "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".
8. Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID   18272466. S2CID   36710246.
9. Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi: 10.1074/jbc.M703121200 . PMC   2244811 . PMID   17616525.

Further reading

• Wilson MP, Sun Y, Cao L, Majerus PW (2001). "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2". J. Biol. Chem. 276 (44): 40998–1004. doi: 10.1074/jbc.M106605200 . PMID   11533064.
• Ho MW, Yang X, Carew MA, et al. (2002). "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase". Curr. Biol. 12 (6): 477–82. doi: 10.1016/S0960-9822(02)00713-3 . PMID   11909533.
• Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. doi: 10.1074/jbc.M208709200 . PMID   12324474.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sun Y, Mochizuki Y, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis". J. Biol. Chem. 278 (44): 43645–53. doi: 10.1074/jbc.M300674200 . PMID   12925536.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Qian X, Mitchell J, Wei SJ, et al. (2005). "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase". Biochem. J. 389 (Pt 2): 389–95. doi:10.1042/BJ20050297. PMC   1175116 . PMID   15762844.
• Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Mol. Cell. 18 (2): 201–12. doi: 10.1016/j.molcel.2005.03.016 . PMID   15837423.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.