ITPK1

ITPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q7D, 2ODT, 2QB5
Identifiers
Aliases	ITPK1 , ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDs	OMIM: 601838 MGI: 2446159 HomoloGene: 8588 GeneCards: ITPK1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	93,116,320 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,671,189 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; amygdala; ; nucleus accumbens; ; sural nerve; ; Brodmann area 9; ; right coronary artery; ; caudate nucleus; ; gallbladder; ; monocyte; ; rectum;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; intestinal villus; ; ileum; ; duodenum; ; jejunum; ; entorhinal cortex; ; large intestine; ; colon; ; Epithelium of stomach; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; isomerase activity ; metal ion binding ; kinase activity ; inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity ; catalytic activity ; inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity ; inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity ; inositol-3,4,6-trisphosphate 1-kinase activity ; ATP binding ; hydrolase activity ; magnesium ion binding ; inositol-1,3,4-trisphosphate 6-kinase activity ; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity ; inositol-1,3,4-trisphosphate 5-kinase activity ; inositol tetrakisphosphate 1-kinase activity ; inositol tetrakisphosphate 6-kinase activity ;
Cellular component	cytosol ; intracellular anatomical structure ; apical plasma membrane ; cytoplasm ;
Biological process	phosphorylation ; blood coagulation ; inositol phosphate metabolic process ; inositol trisphosphate metabolic process ; neural tube development ; signal transduction ; dephosphorylation ; necroptosis ; inositol phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	3705
	217837
	ENSG00000100605 ; ENSG00000274958
	ENSMUSG00000057963
	Q13572
	Q8BYN3
	NM_014216 ; NM_001142593 ; NM_001142594 ; NM_001363707
	NM_172584
	NP_001136065 ; NP_001136066 ; NP_055031 ; NP_001350636
	NP_766172
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 17, 2022

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.^[5]^[6]^[7]

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.^[8]^[9]

Related Research Articles

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1(SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.

1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene. PLCd1 is essential to maintain homeostasis of the skin.

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.

Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene.

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene.

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.

Inositol-polyphosphate multikinase is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase. This enzyme catalyses the following chemical reaction

inositol-1,3,4-trisphosphate 5/6-kinase is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase. This enzyme catalyses the following chemical reaction

References

1 2 3 ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057963 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi: 10.1074/jbc.271.20.11904 . PMID 8662638.
↑ Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC 1221393 . PMID 11042108.
↑ "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".
↑ Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID 18272466. S2CID 36710246.
↑ Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi: 10.1074/jbc.M703121200 . PMC 2244811 . PMID 17616525.

Wilson MP, Sun Y, Cao L, Majerus PW (2001). "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2". J. Biol. Chem. 276 (44): 40998–1004. doi: 10.1074/jbc.M106605200 . PMID 11533064.
Ho MW, Yang X, Carew MA, et al. (2002). "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase". Curr. Biol. 12 (6): 477–82. doi: 10.1016/S0960-9822(02)00713-3 . PMID 11909533.
Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. doi: 10.1074/jbc.M208709200 . PMID 12324474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Sun Y, Mochizuki Y, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis". J. Biol. Chem. 278 (44): 43645–53. doi: 10.1074/jbc.M300674200 . PMID 12925536.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Qian X, Mitchell J, Wei SJ, et al. (2005). "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase". Biochem. J. 389 (Pt 2): 389–95. doi:10.1042/BJ20050297. PMC 1175116 . PMID 15762844.
Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Mol. Cell. 18 (2): 201–12. doi: 10.1016/j.molcel.2005.03.016 . PMID 15837423.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057963 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8662638-5] Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi: 10.1074/jbc.271.20.11904 . PMID 8662638.

[pmid11042108-6] Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC 1221393 . PMID 11042108.

[entrez-7] "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".

[pmid18272466-8] Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID 18272466. S2CID 36710246.

[pmid17616525-9] Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi: 10.1074/jbc.M703121200 . PMC 2244811 . PMID 17616525.

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ITPK1

Related Research Articles

References

Further reading