IVNS1ABP

IVNS1ABP
Identifiers
Aliases	IVNS1ABP , FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP, influenza virus NS1A binding protein, ARA3, IMD70
External IDs	OMIM: 609209 MGI: 2152389 HomoloGene: 31384 GeneCards: IVNS1ABP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	185,317,273 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	151,240,173 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; tibia; ; minor salivary gland; ; Achilles tendon; ; skin of abdomen; ; bone marrow; ; rectum; ; bone marrow cells; ; kidney; ; renal medulla;
	Top expressed in
	Paneth cell; ; myocardium of ventricle; ; medullary collecting duct; ; olfactory epithelium; ; primitive streak; ; cumulus cell; ; aortic valve; ; atrioventricular valve; ; crypt of lieberkuhn of small intestine; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	actin cytoskeleton ; spliceosomal complex ; cytoskeleton ; nucleus ; transcription regulator complex ; nucleoplasm ; cytoplasm ; cytosol ;
Biological process	negative regulation of intrinsic apoptotic signaling pathway ; viral process ; transcription by RNA polymerase III ; RNA splicing ; response to virus ; negative regulation of protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	10625
	117198
	ENSG00000116679
	ENSMUSG00000023150
	Q9Y6Y0
	Q920Q8
	NM_006469 ; NM_016389
NM_001039511 ; NM_001039512 ; NM_028582 ; NM_054102 ; NM_001359262 ;
	NM_001359263
	NP_006460
	NP_001034600 ; NP_001034601 ; NP_473443 ; NP_001346191 ; NP_001346192
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Influenza virus NS1A-binding protein is a protein that in humans is encoded by the IVNS1ABP gene.^[5]^[6]^[7]

In melanocytic cells IVNS1ABP gene expression may be regulated by MITF.^[8]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116679 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023150 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wolff T, O'Neill RE, Palese P (Sep 1998). "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells". J Virol. 72 (9): 7170–80. doi:10.1128/JVI.72.9.7170-7180.1998. PMC 109939 . PMID 9696811.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
↑ "Entrez Gene: IVNS1ABP influenza virus NS1A binding protein".
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID 19067971. S2CID 24698373.

Perconti G, Ferro A, Amato F, et al. (2008). "The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control". Biochim. Biophys. Acta. 1773 (12): 1774–85. doi: 10.1016/j.bbamcr.2007.09.002 . PMID 17996313.
Dunham EE, Stevens EA, Glover E, Bradfield CA (2006). "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein". Mol. Pharmacol. 70 (1): 8–15. doi:10.1124/mol.106.024380. PMID 16582008. S2CID 8164208.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
Harris CE, Boden RA, Astell CR (1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". J. Virol. 73 (1): 72–80. doi:10.1128/JVI.73.1.72-80.1999. PMC 103810 . PMID 9847309.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116679 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023150 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9696811-5] Wolff T, O'Neill RE, Palese P (Sep 1998). "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells". J Virol. 72 (9): 7170–80. doi:10.1128/JVI.72.9.7170-7180.1998. PMC 109939 . PMID 9696811.

[pmid10048485-6] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.

[entrez-7] "Entrez Gene: IVNS1ABP influenza virus NS1A binding protein".

[pmid19067971-8] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID 19067971. S2CID 24698373.

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IVNS1ABP

Related Research Articles

References

Further reading