Ijad Madisch | |
|---|---|
 Ijad Madisch speaks onstage at TechCrunch Disrupt Berlin in 2017 | |
| Born | 7 October 1980 |
| Occupation(s) | Virologist and entrepreneur |
| Scientific career | |
| Thesis | (2007) |
| Doctoral advisor | Albert Heim |
Ijad Madisch (born 7 October 1980 in Wolfsburg, Germany) is a German virologist, founder and CEO of the research network ResearchGate and member of the Digital Council (Digitalrat) of the Cabinet of Germany (Bundesregierung). [1]
Ijad Madisch was born in Wolfsburg to a Syrian family who immigrated to Germany. [2] His elder brother is Ahmed Madisch, a professor and chief physician at Siloah hospital in Hannover. [3] In 2000, Ijad got his Abitur from Ernestinum Celle Gymnasium in Celle. [1]
Ijad Madisch plays Beachvolleyball [4] semi-professionally. His current teammate is the former German national player Finn Dittelbach. [4]
From 2000 to 2007, Ijad Madisch studied medicine at the Hannover Medical School (MHH) and worked in the US at the Massachusetts General Hospital, Boston, Harvard Medical School. From 2002 to 2008, he studied computer sciences at the University of Hagen, but did not complete this degree. [1]
In 2007, Madisch received his doctorate from the MHH in the field of virology [1] with summa cum laude for his work entitled "Molecular Phylogeny and Bioinformatic Analysis as the basis for the typing of human adenoviruses and for the design of organ-specific gene therapy adenoviral vectors ". He received the doctoral prize from MHH for this thesis. [5] [6]
From 2008 to 2010, he went back to Massachusetts General Hospital as a postdoctoral researcher. [1] During this time, Madisch won the Young Investigator Prize of the Radiological Society of North America (RSNA) in Chicago for the project "High-resolution volume CT imaging of tissue-engineered bone growth: correlation between imaging, bio-mechanical strength, and protein transcription analysis". [7]
The decisive factor for his move to the United States was the desire to found ResearchGate, the social network which is specifically created for scientists to exchange their research projects and results. Since 2010, he is the head of the digital platform as chief executive officer (CEO) and has raised 87.6M $ from Bill Gates, Benchmark (venture capital firm), Founders Fund, Goldman Sachs, Ashton Kutcher and others. [3] [8] [9]
Time Magazine named Ijad Madisch a Next Generation Leader. [10]
He also is a member of the selection committee for the Breakthrough Prize Junior Challenge founded by Sergey Brin, Priscilla Chan and Mark Zuckerberg, Yuri Milner and Julia Milner, and Anne Wojcicki. [11] [12]
After a telephone request from the German Chancellor Angela Merkel, Ijad Madisch became on 22 August 2018 a member of the 10-member Digital Council of the Cabinet of Germany. [3]
An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word intron is derived from the term intragenic region, i.e., a region inside a gene. The term intron refers to both the DNA sequence within a gene and the corresponding RNA sequence in RNA transcripts. The non-intron sequences that become joined by this RNA processing to form the mature RNA are called exons.
Adenoviruses are medium-sized, nonenveloped viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953.
Rubella virus (RuV) is the pathogenic agent of the disease rubella, transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy.
The Max Planck Institute for Evolutionary Anthropology is a research institute based in Leipzig, Germany, that was founded in 1997. It is part of the Max Planck Society network.
George McDonald Church is an American geneticist, molecular engineer, chemist, serial entrepreneur, and pioneer in personal genomics and synthetic biology. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard University and Massachusetts Institute of Technology, and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard. Through his Harvard lab Church has co-founded around 50 biotech companies pushing the boundaries of innovation in the world of life sciences and making his lab as a hotbed of biotech startup activity in Boston. In 2018, the Church lab at Harvard made a record by spinning off 16 biotech companies in one year. The Church lab works on research projects that are distributed in diverse areas of modern biology like developmental biology, neurobiology, info processing, medical genetics, genomics, gene therapy, diagnostics, chemistry & bioengineering, space biology & space genetics, and ecosystem. Research and technology developments at the Church lab have impacted or made direct contributions to nearly all "next-generation sequencing (NGS)" methods and companies. In 2017, Time magazine listed him in Time 100, the list of 100 most influential people in the world. In 2022, he was featured among the most influential people in biopharma by Fierce Pharma, and was listed among the top 8 famous geneticists of all time in human history. As of January 2023, Church serves as a member of the Bulletin of the Atomic Scientists' Board of Sponsors, established by Albert Einstein.
Viral vectors are tools commonly used by molecular biologists to deliver genetic material into cells. This process can be performed inside a living organism or in cell culture. Viruses have evolved specialized molecular mechanisms to efficiently transport their genomes inside the cells they infect. Delivery of genes or other genetic material by a vector is termed transduction and the infected cells are described as transduced. Molecular biologists first harnessed this machinery in the 1970s. Paul Berg used a modified SV40 virus containing DNA from the bacteriophage λ to infect monkey kidney cells maintained in culture.
Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene.
Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.
The Neanderthal genome project is an effort of a group of scientists to sequence the Neanderthal genome, founded in July 2006.
ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.
Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.
Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. CAR protein is expressed in several tissues, including heart, brain, and, more generally, epithelial and endothelial cells. In cardiac muscle, CAR is localized to intercalated disc structures, which electrically and mechanically couple adjacent cardiomyocytes. CAR plays an important role in the pathogenesis of myocarditis, dilated cardiomyopathy, and in arrhythmia susceptibility following myocardial infarction or myocardial ischemia. In addition, an isoform of CAR (CAR-SIV) has been recently identified in the cytoplasm of pancreatic beta cells. It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of these cells.
The Natural History Museum of Bern is a museum in Bern, Switzerland. In its teaching and research it cooperates closely with the University of Bern. It is visited by around 131,000 people yearly.
ResearchGate is a European commercial social networking site for scientists and researchers to share papers, ask and answer questions, and find collaborators. According to a 2014 study by Nature and a 2016 article in Times Higher Education, it is the largest academic social network in terms of active users, although other services have more registered users, and a 2015–2016 survey suggests that almost as many academics have Google Scholar profiles.
Adenovirus early region 1A (E1A) is a gene expressed during adenovirus replication to produce a variety of E1A proteins. It is expressed during the early phase of the viral life span.
Cross-species transmission (CST), also called interspecies transmission, host jump, or spillover, is the transmission of an infectious pathogen, such as a virus, between hosts belonging to different species. Once introduced into an individual of a new host species, the pathogen may cause disease for the new host and/or acquire the ability to infect other individuals of the same species, allowing it to spread through the new host population. The phenomenon is most commonly studied in virology, but cross-species transmission may also occur with bacterial pathogens or other types of microorganisms.
Louise Tsi Chow is a professor of biochemistry and molecular genetics at the University of Alabama at Birmingham and a foreign associate with the National Academy of Sciences, known for her research on the human papillomavirus. Her research contributed to the discovery of gene splicing, and in 1993, her collaborator, Richard J. Roberts, received the Nobel Prize for the research, leading some to assert that Chow should have received the honor as well.
Varidnaviria is a realm of viruses that includes all DNA viruses that encode major capsid proteins that contain a vertical jelly roll fold. The major capsid proteins (MCP) form into pseudohexameric subunits of the viral capsid, which stores the viral deoxyribonucleic acid (DNA), and are perpendicular, or vertical, to the surface of the capsid. Apart from this, viruses in the realm also share many other characteristics, such as minor capsid proteins (mCP) with the vertical jelly roll fold, an ATPase that packages viral DNA into the capsid, and a DNA polymerase that replicates the viral genome.
ChAdOx1 is an adenoviral vector for vaccines that was developed by the Jenner Institute, University of Oxford. The vector is a chimpanzee adenovirus modified to avoid its replication.
Martina Sester is a biologist, Professor of Transplantation and Infection Immunology and Head of Department of the Institute of Infection Medicine at Saarland University Hospital as well as former Vice President for Research and Technology Transfer at Saarland University.
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