Inhibitor of cdk, cyclin a1 interacting protein 1

INCA1
Identifiers
Aliases	INCA1 , HSD45, inhibitor of CDK, cyclin A1 interacting protein 1
External IDs	OMIM: 617374; MGI: 2144284; HomoloGene: 19481; GeneCards: INCA1; OMA:INCA1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.2 Start 4,988,130 bp [1] End 4,997,610 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 70,579,187 bp [2] End 70,590,981 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle apex of heart gastrocnemius muscle muscle of thigh duodenum right lobe of thyroid gland mucosa of transverse colon Top expressed in left lobe of liver saccule brown adipose tissue otic vesicle seminiferous tubule tunica adventitia of aorta muscle of thigh soleus muscle spermatocyte embryo More reference expression data BioGPS n/a
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding cyclin binding protein-containing complex binding protein kinase inhibitor activity Cellular component cytoplasm nucleoplasm nuclear body nucleus Biological process positive regulation of apoptotic signaling pathway negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388324 103844 Ensembl ENSG00000196388 ENSMUSG00000057054 UniProt Q0VD86 Q6PKN7 RefSeq (mRNA) NM_001167985 NM_001167986 NM_001167987 NM_213726 NM_001394788 NM_001394789 NM_001394790 NM_001394791 NM_001252482 NM_001252483 NM_001252484 NM_001252485 NM_213729 RefSeq (protein) NP_001161457 NP_001161458 NP_001161459 NP_998891 NP_001239411 NP_001239412 NP_001239413 NP_001239414 NP_998894 Location (UCSC) Chr 17: 4.99 – 5 Mb Chr 11: 70.58 – 70.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inhibitor of CDK, cyclin A1 interacting protein 1 is a protein that in humans is encoded by the INCA1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000196388 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057054 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Inhibitor of CDK, cyclin A1 interacting protein 1" . Retrieved 2018-05-05.

Further reading

• Bäumer N, Tickenbrock L, Tschanter P, Lohmeyer L, Diederichs S, Bäumer S, Skryabin BV, Zhang F, Agrawal-Singh S, Köhler G, Berdel WE, Serve H, Koschmieder S, Müller-Tidow C (August 2011). "Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling". J. Biol. Chem. 286 (32): 28210–22. doi: 10.1074/jbc.M110.203471 . PMC   3151066 . PMID   21540187.