Inositol nicotinate

Last updated

Inositol nicotinate
Inositol nicotinate.png
Clinical data
Trade names Hexopal
AHFS/Drugs.com International Drug Names
Routes of
administration
oral
ATC code
Legal status
Legal status
Identifiers
  • cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.026.806 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C42H30N6O12
Molar mass 810.732 g·mol−1
3D model (JSmol)
Melting point 255 °C (491 °F)
  • O=C(O[C@H]6[C@H](OC(=O)c1cccnc1)[C@H](OC(=O)c2cccnc2)[C@H](OC(=O)c3cccnc3)[C@@H](OC(=O)c4cccnc4)[C@@H]6OC(=O)c5cccnc5)c7cccnc7

Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements. [1]

Contents

Mechanism of action

When ingested, inositol nicotinate breaks down into inositol and niacin. The niacin component helps widen blood vessels (vasodilation), lowers blood lipid levels (including cholesterol), and inhibits a protein involved in blood clotting. [1] [2]

Uses

Inositol nicotinate is used to treat blood circulation problems, including:

Some research shows it can improve symptoms of Raynaud's phenomenon over several weeks. However, its effectiveness in treating other conditions like:

remains unclear, with studies producing mixed results. [1] [3]

Other proposed uses, such as for:

have insufficient supporting evidence. [1]

Side effects

Inositol nicotinate is generally safe when taken by mouth, but possible side effects include:

It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin. [4]

Precautions

Inositol nicotinate should be used with caution in individuals with certain conditions:

References

  1. 1 2 3 4 5 6 7 8 9 "Inositol Nicotinate". WebMD. Retrieved 11 September 2024.
  2. Tomlinson B (2014). "Niacin and inositol hexanicotinate for hyperlipidaemia and vascular disease: new data and new uses for an old drug". Journal of Clinical Pharmacy and Therapeutics. 39 (1): 1–12.
  3. Head A (January 1986). "Treatment of intermittent claudication with inositol nicotinate". The Practitioner. 230 (1411): 49–54. PMID   3513149.
  4. "Niacin: The facts on flushing". BC Drug & Poison Information Centre. Retrieved 11 September 2024.