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Clinical data | |
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Trade names | Hexopal |
AHFS/Drugs.com | International Drug Names |
Routes of administration | oral |
ATC code | |
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Identifiers | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.026.806 |
Chemical and physical data | |
Formula | C42H30N6O12 |
Molar mass | 810.732 g·mol−1 |
3D model (JSmol) | |
Melting point | 255 °C (491 °F) |
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Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements. [1]
When ingested, inositol nicotinate breaks down into inositol and niacin. The niacin component helps widen blood vessels (vasodilation), lowers blood lipid levels (including cholesterol), and inhibits a protein involved in blood clotting. [1] [2]
Inositol nicotinate is used to treat blood circulation problems, including:
Some research shows it can improve symptoms of Raynaud's phenomenon over several weeks. However, its effectiveness in treating other conditions like:
remains unclear, with studies producing mixed results. [1] [3]
Other proposed uses, such as for:
have insufficient supporting evidence. [1]
Inositol nicotinate is generally safe when taken by mouth, but possible side effects include:
It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin. [4]
Inositol nicotinate should be used with caution in individuals with certain conditions: