Insulin like 6

INSL6
Identifiers
Aliases	INSL6 , RIF1, insulin like 6
External IDs	OMIM: 606414 MGI: 1351595 HomoloGene: 5197 GeneCards: INSL6
Gene location (Human)
Chr.	Chromosome 9 (human)
End	5,185,647 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	29,325,356 bp
Gene ontology
Molecular function	• hormone activity ;
Cellular component	• extracellular region ; • cellular component ;
Biological process	• regulation of receptor activity ; • biological process ; • signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	11172
	27356
	ENSG00000120210
	ENSMUSG00000050957
	Q9Y581
	Q9QY05
	NM_007179
	NM_013754
	NP_009110
	NP_038782
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2021

Insulin like 6 is a protein that in humans is encoded by the INSL6 gene. ^[5]

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization.

Related Research Articles

Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor.

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor.

Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene.

Insulin-like peptide INSL5 is a protein that in humans is encoded by the INSL5 gene.

Collagen alpha-5(VI) chain also known as von Willebrand factor A domain-containing protein 4 is a protein that in humans is encoded by the COL6A5 gene.

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene. CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.

Calpain 6 is a protein in humans that is encoded by the CAPN6 gene.

The KSR2 gene is Kinase suppressor of ras 2 it is a protein that in humans is encoded by the KSR2 gene. KSR2 mutation effects in humans by obesity and because KSR2 gene reduces the ERK signaling and it reduces glucose and fatty acid oxidation. KSR2 mutation reduces the glucose and fatty acid oxidation process but it makes growth factor "Epidermal growth factor (EGF)" reaction more faster to simulate cell growth and KSR2 cause insulin resistance, KSA2 gene also regulates how the body uses the energy, and it usually causes type 2 diabetes.

Transmembrane protein 219 also known as insulin-like growth factor-binding protein 3 receptor or IGFBP-3R is a protein that in humans is encoded by the TMEM219 gene. IGFBP-3R acts as a cell death receptor for IGFBP3.

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene.

IGF like family member 3 is a protein that in humans is encoded by the IGFL3 gene.

MYCBP associated protein is a protein that in humans is encoded by the MYCBPAP gene.

SPANX family member N1 is a protein that in humans is encoded by the SPANXN1 gene.

PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene.

TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene.

Serine protease 55 is a protein that in humans is encoded by the PRSS55 gene.

Testis specific serine kinase 1B is a protein that in humans is encoded by the TSSK1B gene.

MORC family CW-type zinc finger 1 is a protein that in humans is encoded by the MORC1 gene.

Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120210 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050957 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Insulin like 6" . Retrieved 2016-02-25.

Insulin like 6

Contents

Function

Related Research Articles

References

Further reading